Kukol, Andreas - University of Hertfordshire

个人简介

I am a biophysical chemist experienced in computational modelling and dynamics simulation of bio-macromolecules, FTIR spectoscopy of membrane proteins in model-membrane systems as well as molecular characterisation of surface-attached bioprobes in biosensors. For current research interests please see 'Expertise'-tab . I am a fellow of the Institute of Biomedical Sciences and the Higher Education Academy, as well as a member of the Biochemical Society and the German Biophysical Society. Within the Department of Biological and Environmental Sciences I am the Research Coordinator and a member of the Bioscience Research Group.

研究领域

We are interested in the structure and function of bio-macromolecules in biological systems. We use methods of computational biochemistry, biological chemistry, biophysics and bioinformatics to address topics such as antiviral drug target characterisation, cardiac transmembrane protein-protein interaction and oligonucleotide-based biosensors for pathogens. More details, downloads and current job opportunities can be found on the Research Group Page. Visiting researchers with their own funding are welcome. Additionally, I will support applications for research fellowships and PhD studentships via overseas or EU/UK funding organisations, for example the EU-funded Marie-Curie Actions. Please see the Research Degrees page.

近期论文

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Evaluation of a novel virtual screening strategy using receptor decoy binding sitesPatel, H. & Kukol, A. 23 Aug 2016 In : Journal of Negative Results in BioMedicine. 15, 15, 5 p. Recent discoveries of influenza A drug target sites to combat virus replicationPatel, H. & Kukol, A. 9 Jun 2016 In : Biochemical Society Transactions. 44, 3, p. 932-36 5 p. Regulation of the Cardiac Na+/K+ ATPase by PhospholemmanDhayan, H., Kumar, R. & Kukol, A. 16 Dec 2015 Regulation of Membrane Na+-K+ ATPase. Chakraborti, S. & Dhalla, N. (eds.). Springer International Publishing, Vol. 15, p. 261 276 p. (Advances in Biochemistry in Health and Disease; vol. 15) Molecular modeling of influenza A virus proteinsPatel, H., Rapley, R. & Kukol, A. 8 Dec 2015 Enzyme Kinetics Lecture NotesKukol, A. 14 Aug 2015 North Charleston: Create Space Independent Publishing Platform. 75 p. Lipid membranes for membrane proteinsKukol, A. 1 Jan 2015 Molecular Modeling of Proteins. Kukol, A. (ed.). Clifton: Humana Press / Springer, p. 73-90 (Methods in Molecular Biology; vol. 1215) Molecular Modeling of ProteinsKukol, A. (ed.) 1 Jan 2015 2nd ed. Clifton: Humana Press / Springer. 474 p. (Methods in Molecular Biology; vol. 1215) A cellulose-based bioassay for the colorimetric detection of pathogen DNASaikrishnan, D., Goyal, M., Rossiter, S. & Kukol, A. 1 Dec 2014 In : Analytical and Bioanalytical Chemistry. 406, 30, p. 7887-7898 G-quadruplex formation of FXYD1 pre-mRNA indicates the possiblity of regulating expression of its protein productDhayan, H., Baydoun, A. R. & Kukol, A. 15 Oct 2014 In : Archives of Biochemistry and Biophysics. 560, p. 52-58 Influenza A nucleoprotein binding sites for antivirals: current research and future potentialKukol, A. & Patel, H. 15 Sep 2014 In : Future Virology. 9, 7, p. 625-627 Large-scale analysis of influenza A virus nucleoprotein sequence conservation reveals potential drug-target sitesKukol, A. & Hughes, D. Apr 2014 In : Virology. 454-455, p. 40-47 8 p. How the amyloid-β peptide and membranes affect each other: An extensive simulation studyPoojari, C., Kukol, A. & Strodel, B. Feb 2013 In : Biochimica et Biophysica Acta - Biomembranes. 1828, 2, 327-339 Novel approaches to better understand R gene-mediated resistance in oilseed rapeStotz, H., Harvey, P., Rafi, M. S., de Lope, L., Dahm, T., Huang, Y., Kukol, A. & Fitt, B. D. L. 2013 Development of lux-based biosensors in P. aeruginosa ATCC 9027 for preservative efficacy testingShah, N., Kukol, A. & Naseby, D. 2012 Consensus virtual screening approaches to predict protein ligandsKukol, A. 2011 In : European Journal of Medicinal Chemistry. 46, 9, p. 4661-4664 Structure and dynamics of the kinase IKK-β – A key regulator of the NF-kappa B transcription factorKalia, M. & Kukol, A. 2011 In : Journal of Structural Biology. 176, 2, p. 133-142 Large-scale analysis of Influenza A virus sequences reveals potential drug-target sites of non-structural proteinsDarapaneni, V., Prabhakar, V. & Kukol, A. Oct 2009 In : Journal of General Virology. 90, 9, p. 2124-2133 Lipid models for united-atom molecular dynamics simulations of proteinsKukol, A. 2009 In : Journal of Chemical Theory and Computation. 5, 3, p. 615-626 Solid-state O-17 NMR spectroscopy of a phospholemman transmembrane domain protein: Implications for the limits of detecting dilute 170 sites in biomaterialsWong, A., Beevers, A. J., Kukol, A., Dupree, R. & Smith, M. E. May 2008 In : Solid State Nuclear Magnetic Resonance. 33, 4, p. 72-75 4 p. Label free electrical detection of DNA hybridisation for the example of influenza virus gene sequencesKukol, A., Li, P., Estrela, P., Ko-Ferrigno, P. & Migliorato, P. 2008 In : Analytical Biochemistry. 374, 1, p. 143-153