Iravani, Mahmoud - University of Hertfordshire - Department of Pharmacy, Pharmacology and Postgraduate Medicine

个人简介

Mahmoud Iravani has a long standing research interest in neurodegeneration mechanisms in Parkinson’s Disease and L-Dopa induced dyskinesia with Peter Jenner at Neurodegenerative Disease Research Centre at King's College London. Most recently at King’s College London, in collaboration with Professors Paul Francis and Clive Ballard, he investigated the anti-apoptotic and anti-aggregative role of various agents in the lactacystin model of Parkinson’s disease. A second project, which is still ongoing, has involved imaging of the structural changes in the primate brains following MPTP treatment, using MRI at the Institute of Psychiatry. At the University of Herfordshire his focus will be primarily on Parkinson’s disease neuropathology as well as novel treatments for L-dopa induced dyskinesia. Specifically, he will focus on the non-dopaminergic aspects of the parkinsonian pathology and role of inflammation in protein aggregation and the treatment of of l-dopa induced dyskinesia. In the first instance, achieving these goals, will be pursued by collaborating with colleagues at King’s College London. In addition, he will be submitting grant applications to identify the mechanisms of PD induced non-motor dysfunction.

研究领域

Neurodegeneration in Parkinson's disease Role of antidyskinetic agents in the treatment of L-DOPA induced dyskinesia Role of inflammation in neurodegenerative processes Role of intracellular protein aggregation in neurodegneration Non-dopaminergic dysfunction in Parkinson's disease: dysautonomia

近期论文

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Arylalkylpiperazines for use as neuroprotective agents: Arlyalkylpiperazines and neuroprotectionIravani, M. 7 Apr 2016 WO2016051155 A1 Loss of locus coeruleus noradrenergic neurons alters the inflammatory response to LPS in substantia nigra but does not affect nigral cell lossIravani, M. M., Sadeghian, M., Rose, S. & Jenner, P. 1 Dec 2014 In : Journal of Neural Transmission. 121, 12, p. 1493-1505 The H3 receptor agonist immepip does not affect l-dopa-induced abnormal involuntary movements in 6-OHDA-lesioned ratsPapathanou, M., Jenner, P., Iravani, M. M., Jackson, M., Stockwell, K., Strang, I., Zeng, B-Y., McCreary, A. & Rose, S. 15 Oct 2014 In : European Journal of Pharmacology. 741, p. 304-310 Physiological and Functional Changes in the Colon of MPTP-Treated Common MarmosetsColetto, E., Tough, I., Hikima, A., Iravani, M. M., Chaudhuri, K. R., Jenner, P., Cox, H. & Rose, S. May 2014 In : Movement disorders. 29, Suppl 1, 1525 The spontaneous and neurogenic contractile responses of the isolated bladder smooth muscle are markedly enhanced in MPTP treated common marmoset (Callithrix jacchus)Pritchard, S., Jackson, M., Lione, L., Benham, C., Rose, S., Jenner, P. & Iravani, M. M. Dec 2013 In : pA2 Online. 11, 3, 208P Increase in the number of striatal neuronal nitric oxide synthase immunoreactive (nNOS-ir) interneurones in MPTP-treated common marmosets primed for and displaying levodopa-induced dyskinesiaPeeris, M., Geraldes, L., Jackson, M., Hikima, A., Broadstock, M., Rose, S., Jenner, P. & Iravani, M. M. 2013 In : pA2 Online. 11, 3, 2 p., 219P Lipopolysaccharide-induced nigral inflammation leads to increased IL-1β tissue content and expression of astrocytic glial cell line-derived neurotrophic factor.Iravani, M. M., Sadeghian, M., Leung, C. C. M., Jenner, P. & Rose, S. 29 Feb 2012 In : Neuroscience Letters. 510, 2, p. 138-142 5 p. Striatal plasticity in Parkinson's disease and L-DOPA induced dyskinesiaIravani, M. M., McCreary, A. C. & Jenner, P. 18 Jan 2012 In : Parkinsonism and Related Disorders. 18, S1, p. 123-125 3 p. Mechanisms underlying the onset and expression of levodopa-induced dyskinesia and their pharmacological manipulationIravani, M. M. & Jenner, P. Dec 2011 In : Journal of Neural Transmission. 118, 12, p. 1661-1690 30 p. The effect of nNOS inhibitors on toxin-induced cell death in dopaminergic cell lines depends on the extent of enzyme expressionBrzozowski, M. J., Alcantara, S. L., Iravani, M. M., Rose, S. & Jenner, P. 2 Aug 2011 In : Brain Research. 1404, p. 21-30 10 p. Morphological changes in serotoninergic neurites in the striatum and globus pallidus in levodopa primed MPTP treated common marmosets with dyskinesiaZeng, B-Y., Iravani, M. M., Jackson, M. J., Rose, S., Parent, A. & Jenner, P. Dec 2010 In : Neurobiology of Disease. 40, 3, p. 599-607 9 p. Continuous rotigotine administration reduces dyskinesia resulting from pulsatile treatment with rotigotine or L-DOPA in MPTP-treated common marmosetsStockwell, K. A., Scheller, D. K. A., Smith, L. A., Rose, S., Iravani, M. M., Jackson, M. J. & Jenner, P. Jan 2010 In : Experimental Neurology. 221, 1, p. 79-85 7 p. Continuous administration of rotigotine to MPTP-treated common marmosets enhances anti-parkinsonian activity and reduces dyskinesia inductionStockwell, K. A., Scheller, D., Rose, S., Jackson, M. J., Tayarani-Binazir, K., Iravani, M. M., Smith, L. A., Olanow, C. W. & Jenner, P. Oct 2009 In : Experimental Neurology. 219, 2, p. 533-542 10 p. An immunohistochemical and stereological analysis of PSI-induced nigral neuronal degeneration in the ratBukhatwa, S., Iravani, M. M., Zeng, B-Y., Cooper, J. D., Rose, S. & Jenner, P. Apr 2009 In : Journal of Neurochemistry. 109, 1, p. 52-59 8 p. Continuous subcutaneous infusion of pramipexole protects against lipopolysaccharide-induced dopaminergic cell death without affecting the inflammatory responseIravani, M. M., Sadeghian, M., Leung, C. C. M., Tel, B. C., Rose, S., Schapira, A. H. & Jenner, P. Aug 2008 In : Experimental Neurology. 212, 2, p. 522-531 10 p. Proteasomal abnormalities in cortical Lewy body disease and the impact of proteasomal inhibition within cortical and cholinergic systemsMacInnes, N., Iravani, M. M., Perry, E., Piggott, M., Perry, R., Jenner, P. & Ballard, C. Jun 2008 In : Journal of Neural Transmission. 115, 6, p. 869-878 10 p. Continuous delivery of ropinirole reverses motor deficits without dyskinesia induction in MPTP-treated common marmosetsStockwell, K. A., Virley, D. J., Perren, M., Iravani, M. M., Jackson, M. J., Rose, S. & Jenner, P. May 2008 In : Experimental Neurology. 211, 1, p. 172-179 8 p. Continuous vs pulsatile administration of rotigotine in rat and monkey models of Parkinson's disease: A comparisonScheller, D. K. A., Schmidt, W. J., Jackson, M. J., Ruess, U., Stockwell, K., Heindl, M., Iravani, M. M., Tayarani-Binazir, K., Rose, S. & Jenner, P. 2008 In : Movement disorders. 23, Supp 1, p. S86 1 p., 249 In 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine-treated primates, the selective 5-hydroxytryptamine 1a agonist (R)-(+)-8-OHDPAT inhibits levodopa-induced dyskinesia but only with\increased motor disabilityIravani, M. M., Tayarani-Binazir, K., Chu, W. B., Jackson, M. J. & Jenner, P. Dec 2006 In : Journal of Pharmacology and Experimental Therapeutics. 319, 3, p. 1225-1234 10 p. Inhibition or Treatment of DyskinesiaIravani, M. M. & Jenner, P. 24 Aug 2006 WO/2006/087577