MacKenzie, Louise Susan - University of Hertfordshire - Department of Pharmacy, Pharmacology and Postgraduate Medicine

研究领域

Dr. Louise Mackenzie (nee LS Harrington) is a senior lecturer in Pharmacology at the University of Hertfordshire, and is an honorary lecturer of pharmacology and toxicology at Imperial College, London. I have worked and studied at numerous universities, including Oxford University (The Welcome Trust for Human Genetics) and UCL (the Hatter Institute), which gave a solid background in molecular biology. I went on to complete my PhD in 2003 at the NHLI, Imperial College (St Mary’s Hospital) in medical biochemsitry, working on human vascular smooth muscle cell signalling pathways. For the following 10 years I worked as a post-doctoral researcher at the NHLI (Imperial College) and the William Harvey Research Institute (Queen Mary’s University) and formed a close working relationship with Prof Jane Mitchell and Prof Tim Warner. My current research areas are eicosanoid and PPAR biology in cardiovascular and respiratory pharmacology, with specific interests in the role and modulation of vasoactive hormones. Research expertise extends into resistance vessel bioassay in vitro with particular reference to the role and modulation of nitric oxide, eicosanoids, cyclo-oxygenase (COX) enzymes, and PPARβ/δ receptors on organ function.

近期论文

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A New NO-Releasing Nanoformulation for the Treatment of Pulmonary Arterial HypertensionMohamed, N. A., Ahmetaj-Shala, B., Duluc, L., Mackenzie, L. S., Kirkby, N. S., Reed, D. M., Lickiss, P. D., Davies, R. P., Freeman, G. R., Wojciak-Stothard, B., Chester, A. H., El-Sherbiny, I. M., Mitchell, J. A. & Yacoub, M. H. Apr 2016 In : Journal of cardiovascular translational research. 9, 2, p. 162-164 Evidence that Diclofenac and Celecoxib are thyroid hormone receptor beta antagonistsZloh, M., Perez Diaz, N., Tang, L., Patel, P. & MacKenzie, L. S. 1 Feb 2016 In : Life sciences. 146, p. 66-72 Methylglyoxal, A Metabolite Increased in Diabetes is Associated with Insulin Resistance, Vascular Dysfunction and NeuropathiesShamsaldeen, Y., MacKenzie, L., Lione, L. & Benham, C. 2016 In : Current Drug Metabolism. 17, 4, p. 359-367 8 p. In silico modelling of prostacyclin and other lipid mediators to nuclear receptors reveal novel thyroid hormone beta receptor antagonist properties.Perez Diaz, N., Zloh, M., Patel, P. & MacKenzie, L. S. 11 Dec 2015 In : Prostaglandins and Other Lipid Mediators. 122, p. 18-27 Reply to Letter Regarding Article, "Evidence That Links Loss of Cyclooxygenase-2 With Increased Asymmetric Dimethylarginine: Novel Explanation of Cardiovascular Side Effects Associated With Anti-Inflammatory Drugs"Ahmetaj-Shala, B., Kirkby, N. S., Knowles, R., Al'Yamani, M., Mazi, S., Wang, Z., Tucker, A. T., Mackenzie, L. S., Armstrong, P. C. J., Nüsing, R. M., Tomlinson, J. A. P., Warner, T. D., Leiper, J. & Mitchell, J. A. 27 Oct 2015 In : Circulation. 132, 17, p. e213-4 Identification of novel compounds that inhibit S100P and RAGE binding as a new therapy for Pancreatic CancerMacKenzie, L. Aug 2015 1 p. Evidence that links loss of cyclooxygenase-2 with increased asymmetric dimethylarginine: novel explanation of cardiovascular side effects associated with anti-inflammatory drugsAhmetaj-Shala, B., Kirkby, N. S., Knowles, R., Al'Yamani, M., Mazi, S., Wang, Z., Tucker, A. T., Mackenzie, L., Armstrong, P. C. J., Nüsing, R. M., Tomlinson, J. A. P., Warner, T. D., Leiper, J. & Mitchell, J. A. 17 Feb 2015 In : Circulation. 131, 7, p. 633-42 10 p. Linking Induction and Transrepression of PPARβ/δ with Cellular FunctionPerez Diaz, N. & MacKenzie, L. S. 26 Jan 2015 In : Annual Research and Review in Biology. 6, 4, p. 253-263 Role of prostacyclin in pulmonary hypertensionMitchell, J. A., Ahmetaj-Shala, B., Kirkby, N., Wright, W. R., MacKenzie, L. S., Reed, D. & Mohamed, N. 31 Dec 2014 In : Global Cardiology Science and Practice. 2014, 4, 12 p., 53 The PPARβ/δ agonist GW0742 prevents LPS-induced nitrite production in rat parenchyma but not in aorta or pulmonary arteriesPerez Diaz, N., Barakat, J., Perez-Vizcaino, F., Moreno, L. & MacKenzie, L. S. Dec 2014 In : pA2 Online. 12, 3, 215P Selective inhibition of NADPH Oxidase reverses the over contraction of diabetic rat aortaRehman, A. U., Dugic, E., Benham, C., Lione, L. & MacKenzie, L. S. 2014 In : Redox Biology. 2, p. 61-64 Harnessing the benefits of PPARβ/δ agonistsMacKenzie, L. S. & Lione, L. Dec 2013 In : Life Sciences. 93, 25-26, p. 963-967 Linking Phospholipase C isoforms with differentiation function in human vascular smooth muscle cellsMacKenzie, L. S., Lymn, J. & Hughes, A. D. Dec 2013 In : BBA - Molecular Cell Research . 1833, 12, p. 3006-3012 Aspirin triggered 15-epi-lipoxin A4 predicts cyclo-oxygenase-2 in the lungs of LPS treated mice but not in the circulation: implications for a clinical testKirkby, N., Chan, M. V., Lundberg, M. H., MacKenzie, L., Leadbeater, P. D. M., Milne, G. L., Potter, C. M., Al-Yamani, M., Adeyemi, O., Warner, T. D. & Mitchell, J. A. Oct 2013 In : FASEB Journal. 27, p. 3938-46 NADPH oxidase is the source of ROS in STZ rat aorta: use of the novel highly selective NOX inhibitor VAS2870Dugic, E., Shamsaldeen, Y., Benham, C. D. & MacKenzie, L. Sep 2013 Young Life Scientists Symposium 2013. LC-MS/MS Confirms That COX-1 Drives Vascular Prostacyclin Whilst Gene Expression Pattern Reveals Non-Vascular Sites of COX-2 ExpressionKirkby, N. S., Zaiss, A. K., Urquhart, P., Jiao, J., Austin, P. J., Al-Yamani, M., Lundberg, M. H., MacKenzie, L., Warner, T. D., Nicolaou, A., Herschman, H. R. & Mitchell, J. A. 9 Jul 2013 In : PLoS ONE. 8, 7, e69524 Nitric oxide-dependent vasodilation is compromised in isolated pulmonary arteries from COX knockout miceWright, W., MacKenzie, L. S., Kirkby, N. S. & Mitchell, J. A. Apr 2013 In : FASEB Journal. 27, 1 p., lb603 Cross-talk between toll-like receptor 4 (TLR4) and proteinase-activated receptor 2 (PAR) is involved in vascular functionBucci, M., Vellecco, V., Brancaleone, V., Roviezzo, F., Mattace Raso, G., Ianaro, A., Meli, R., Cirino, G., Harrington, L., Lungarella, G. & De Palma, R. 2013 In : British Journal of Pharmacology. 168, 2, p. 411-420 10 p. Vasodilation induced by PPARβ /δ agonists is greater at higher pressures than lower pressures in rat pulmonary arteriesMacKenzie, L. S., Wright, W. R., Warner, T. D. & Mitchell, J. A. Dec 2012 Cyclooxygenase-1, not cyclooxygenase-2, is responsible for physiological production of prostacyclin in the cardiovascular systemKirkby, N. S., Lundberg, M. H., Harrington, L. S., Leadbeater, P. D. M., Potter, C. M. F., Al-Yamani, M., Adeyemi, O., Mitchell, J. A., Warner, T. D. & Milne, G. L. 23 Oct 2012 In : Proceedings of the National Academy of Sciences of the United States of America. 109, 43, p. 17597-17602 6 p.