Lione, Lisa - University of Hertfordshire - Department of Pharmacy, Pharmacology and Postgraduate Medicine

研究领域

Dr Lisa Lione is an in vivo behavioural neuropharmacologist with 10 years drug discovery expertise in biotechnology and pharmaceutical industries, including co-founding a private held biotechnological company (Cambridge Biotechnology Ltd, CBT). In industry, Lisa directed in vivo research in pain, obesity and cognition providing decision making data to deliver novel patented candidate drugs into clinical development, including the gold standard treatment Pregbalin (Lyrica®) for diabetic neuropathic pain. Lisa joined UH in 2008 managing the in vivo diabetes research projects as the Home Office project licence holder (PPL70/7732, Diabetes mechanisms and treatment, 2013-2018). At UH Lisa currently supervises 6 PhD students, 4 of whom are working under her licence. Lisa's research aims include: 1. Investigating the involvement of TRPV ion channels, PPARβδ, glucose metabolites and natural plant products in glucose sensing, vascular dysfunction and neuropathic pain (in collaboration with the IPHAMETRA Institute, Gabon, Africa, Prof Alain DeSouza, 2014-2017, £48,450 funded PhD studentship) 2. Providing consultation studies for the discovery and development of novel analgesics for diabetic neuropathic pain in collaboration with the CRO, Transpharmation Ltd (Dr Neil Upton). 3. Improving the predictive validity and animal welfare of models of diabetes by investigating novel 'non-evoked' naturalistic behaviours (cognitive, burrowing). 4. Identifying biomarkers of neuropathic pain and improve responder rates to analgesia in diabetes using behaviour and transcriptomics (with Transpharmation Ltd, requires funding) 5. Understanding the pharmacological mechanisms underlying ketamine and novel psychoactive substances induced bladder hypersensitivity (in collaboration with Dr Stair, Dr Fergus at UH)

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The streptozocin model of diabetes, induces neuropathic pain & changes in quality of life measures which can be modulated by social interaction/welfareFisher, A., Upton, N. & Lione, L. Sep 2016 In : AISP at the 16th World Congress on Pain, Japan. Global Survey on Novel Psychoactive Substances & Effects of Ketamine in Lower Urinary tractElena Deligiani, Corkery, J. & Lione, L. 31 May 2016 TRPV4 dysfunction in endothelial cells from STZ treated rats reversed by insulin.Shamsaldeen, Y., Lione, L. & Benham, C. 17 Apr 2016 New Therapeutics for Diabetes and Obesity Keynote symposium, California. Methylglyoxal, A Metabolite Increased in Diabetes is Associated with Insulin Resistance, Vascular Dysfunction and NeuropathiesShamsaldeen, Y., MacKenzie, L., Lione, L. & Benham, C. 2016 In : Current Drug Metabolism. 17, 4, p. 359-367 8 p. Decrease in TRPV4 Expression in Vascular Endothelium From STZ Treated Rats is Reversed by Insulin Treatment,: (oral communication)Shamsaldeen, Y., Lione, L. & Benham, C. 17 Dec 2015 pA2 online vol 13. pA2 online vol 13 The streptozocin model of diabetes induces neuropathic pain, anhedonia and impaired burrowing in ratsFisher, A., Kennard, P., Upton, N. & Lione, L. 17 Dec 2015 p. pA2 online vol 13 Impairment in burrowing in the rat streptozocin (STZ) diabetes model of neuropathic pain and the benefits of social housingFisher, A., Burnett, M., Pye, L., Upton, N. & Lione, L. 15 Jun 2015 NC3Rs/Society of Biology 3Rs Symposium, London. The ‘legal high’ dissociatives, diphenidine and methoxphenidine, have different effects on the rodent dopamine system.Dutta, N., Opacka-Juffry, J., Gant, A., Lione, L. & Davidson, C. 15 Apr 2015 Britisih Neuroscience Association conference, Edinburgh. Modulation of TRPV1 Function in Sensory NeuropathyPritchard, S. & Lione, L. 3 Feb 2015 Impairment in burrowing in the rat streptozocin (STZ) diabetes model of neuropathic pain and the benefits of social housingBurnett, M., Fisher, A., Pye, L., Upton, N. & Lione, L. Dec 2014 pA2 online. 3 ed. pA2 online, Vol. 12, p. 066P 12(3) TRPV4 Dysfunction in Both Endothelial and Smooth Muscle Cells From Diabetic Rat AortaShamsaldeen, Y., Benham, C. & Lione, L. Dec 2014 pA2 online. 3 ed. Vol. 12, p. 212P Contribution Of TRPA1 Agonist Actions Of Methylglyoxal To Colon Motility Dysfunction In DiabetesAssiri, A., Benham, S., Pritchard, S., Lione, L. & Benham, C. 2014 pA2 online. 3 ed. pA2 online, Vol. 12, p. 080P Effects of Methoxetamine in rat bladder and nucleus accumbens brain tissue.Davidson, C., Hashomi , G., Gant, A., Fergus, S., Benham, C. & Lione, L. 2014 Res Advanced Psychiatry . Vol. 1:30 Selective inhibition of NADPH Oxidase reverses the over contraction of diabetic rat aortaRehman, A. U., Dugic, E., Benham, C., Lione, L. & MacKenzie, L. S. 2014 In : Redox Biology. 2, p. 61-64 Complex effects on rat aorta tone of acute methylglyoxal treatmentShamsaldeen, Y., Lione, L. & Benham, C. Dec 2013 p. 055P Harnessing the benefits of PPARβ/δ agonistsMacKenzie, L. S. & Lione, L. Dec 2013 In : Life Sciences. 93, 25-26, p. 963-967 The spontaneous and neurogenic contractile responses of the isolated bladder smooth muscle are markedly enhanced in MPTP treated common marmoset (Callithrix jacchus)Pritchard, S., Jackson, M., Lione, L., Benham, C., Rose, S., Jenner, P. & Iravani, M. M. Dec 2013 In : pA2 Online. 11, 3, 208P Senior lecturer to assessor: Appraisal of theories related to assessment from a new lecturer perspectiveLione, L. 2009 In : Blended Learning in Practice. 2009, January, p. 36-43 Compounds for the treatment of pain: WO2004/078183Lione, L., Richardson, P. J. & Lee, K. 2007 WO2004/078183 Use of spongosine (2-methoxy adenosein) for the treatment of pain, in particular hyperalgesiaLione, L., Richardson, P. J. & Lee, K. 2007 US2007/0010475