研究领域

Role of inflammation and ageing on sensory signalling in the GI tract Role of serotonergic, TRP and P2X signalling processes in mediating sensory signalling in the GI tract Role of TRP channel activity in modulating GI motility Design of novel safety pharmacology screens to assess drug safety profiles

My research interests are focused on studying the neural control of gastrointestinal function. Specifically I wish to understand how processes such as ageing and inflammation affect the organization and function of gastrointestinal sensory neural pathways, and how this impacts upon human health. I use a variety of experimental protocols including electrophysiology, molecular biology, and immunohistochemistry to identify the pathways and characterise the molecules involved in regulating gastrointestinal sensory signalling processes. I have also collaborated with industry to develop biomarkers of gastrointestinal adverse drug reactions for use in safety pharmacology screening procedures.

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In vitro recording of mesenteric afferent nerve activity in jejunal and colonic segments from rodentsNullens, S., Deiteren, A., Jiang, W., Keating, C., Ceuleers, H., Franque, S., Grundy, D., de Man, J. D. M. & de Winter, B. 10 May 2016 In : Journal of Visualised Experiments. Afferent mesenteric nerve firing and activation of DRGs and CNS in a murine model of sepsisNullens, S., Deleye, S., deiteran, A., Jiang, W., Keating, C., balemans, D., Wouters, J. M., Franque, S., de Man, J., Staelens, S. & de Winter, B. 2016 In : Gut. Ageing and Gastrointestinal Sensory FunctionKeating, C. & Grundy, D. 2016 In : Advances in Experimental Medicine and Biology. 891, p. 71- 74 TRPA1 channel activation regulates motility in the mouse colonSleet, B. & Keating, C. 2016 In : pA2 online. The role of TRPA1 in regulating colonic motilityCousins, Z., Sleet, B. & Keating, C. 2016 Mechanisms contributing to visceral hypersensitivity: focus on splanchnic afferent nerve signallingDeiteren, A., de Man, J., Keating, C., Jiang, W., de Schepper, H., Pelckmans, P., Francque, S. & de Winter, B. Dec 2015 In : Neurogastroenterology and Motility. 27, 12, p. 1709-1720 Study of the mechanisms contributing to visceral hypersensitivity in a rat model of acute and postinflammatory colitis: focus on splanchnic afferent nerve signalingDeiteren, A., de Man, J. D. M., Keating, C., Jiang, W., Pelckmans, P. & de Winter, B. Jun 2015 In : Neurogastroenterology and Motility. 27, S2, p. 53-54 The effect of prolonged CLP-induced sepsis on jejunal mesenteric afferent nerve activity in miceNullens, S., Deiteren, A., de Man, J., Keating, C., Jiang, W., Grundy, D. & de Winter, B. Jun 2015 In : Neurogastroenterology and Motility. 27, S2, p. 22 001 Ageing and gastrointestinal sensory function: altered colonic mechanosensory and chemosensory function in the aged mouseKeating, C. & Grundy, D. 2015 In : pA2 Online. 21, 3, 258P Entry in progressAgeing and gastrointestinal sensory function: altered colonic mechanosensory and chemosensory function in the aged mouse.Keating, C., Nochi, L., Yu, Y., Donovan, J. & Grundy, D. 2015 In : Journal of Physiology. Translational potential of a mouse in-vitro bioassay in predicting gastrointestinal adverse drug reactions in phase 1 clinical trialsKeating, C., Ewart, L., Grundy, L., Valentin, J-P. & Grundy, D. Jul 2014 In : Neurogastroenterology and Motility. 26, 7, p. 980-9 P2X 7 receptor-dependent intestinal afferent hypersensitivity in a mouse model of postinfectious irritable bowel syndromeKeating, C., Pelegrin, P., Martínez, C. M. & Grundy, D. 1 Aug 2011 In : Journal of Immunology. 187, 3, p. 1467-1474 8 p. The validation of an invitro colonic motility assay as a biomarker for gastrointestinal adverse drug reactionsKeating, C., Ewart, L., Gibbons, S., Grundy, L., Valentin, J-P. & Grundy, D. Jun 2010 In : Toxicology and Applied Pharmacology. 245, 3, p. 299-309 Purinergic contribution to small intestinal afferent hypersensitivity in a murine model of post infectious bowel disease.Rong, W., Keating, C., Sun, B., Dong, L. & Grundy, D. Jun 2009 In : Neurogastroenterology and Motility. 21, 6, p. 665-671 Post-infectious visceral hypersensitivity persists in the TRPV1 knockout mouseKeating, C. & Grundy, D. May 2009 In : Gastroenterology. 136, 5 (Supp 1), p. A-75 Afferent hypersensitivity in a mouse model of post-inflammatory gut dysfunction: role of altered serotonin metabolismKeating, C., Beyak, M., Foley, S., Singh, G., Marsden, C., Spiller, R. & Grundy, D. Sep 2008 In : Journal of Physiology. 586, 18, p. 4517-4530 Intestinal Secretory and Absorptive Function in the Trichinella spiralis mouse model of Post-Infective Gut Dysfunction: role of bile acidsKalia, N., Hardcastle, J., Grassi, L., Keating, C., Pelegrin, P., Bardhan, K. D. & Grundy, D. 2008 In : Gut. 57, 1, p. 41-49 Extrinsic Sensory Afferent Nerves Innervating the Gastrointestinal TractBeyak, M., Bulmer, D., Jiang, W., Keating, C., Rong, W. & Grundy, D. 2006 Physiology of the Gastrointestinal Tract. Johnson, L. R., Barrett, K. E., Ghishan, F. K., Merchant, J. L., Said, H. M. & Wood, J. D. (eds.). 4th ed. McGraw-Hill, Vol. 1, p. 685-726 41 p. The effects of dopamine agonists and antagonists on the secretory responses in the salivary glands of the locust (Locusta migratoria)Keating, C. & Orchard, I. Jan 2004 In : Journal of Insect Physiology. 50, 1, p. 17-23 Whole-Genome Analysis of 60 G Protein-Coupled Receptors in Caenorhabditis elegans by Gene Knockout with RNAiKeating, C., Kriek, N., Daniels, M., Ashcroft, N. R., Hopper, N. A., Siney, E. J., Holden-Dye, L. & Burke, J. F. Sep 2003 In : Current Biology. 13, 19, p. 1715-1720