Gerhard, Ute - University of Hertfordshire - Department of Pharmacy, Pharmacology and Postgraduate Medicine

个人简介

Dr Gerhard has an MSc in Chemistry (Dipl Chem) from the University of Cologne and was awarded a PhD from the University of Cambridge for her work with Professor Dudley Williams, investigating the molecular interactions of small peptides in aqueous solutions. Ute has a strong research track record, with over 19 years experience in pharmaceutical research and development, and she is author of over 25 publications to date. She was awarded the American Association of Pharmaceutical Scientists (AAPS) Outstanding Manuscript Award in Analysis and Pharmaceutical Quality in 2004. Ute is an expert in spectroscopic techniques such as NMR spectroscopy and Mass spectrometry. She has applied her wide ranging analytical and problem solving expertise in the pharmaceutical industry to support chemical development, manufacturing, basic research including medicinal chemistry and drug metabolism. Ute is a Fellow of the Higher Education Academy and a Member of the Royal Society of Chemistry.

研究领域

Structure elucidation by NMR and MS and other analytical techniques Chemical stability of formulated drugs and structure elucidation of degradation products Drug metabolism and metabolite structure identification Non-covalent interactions of small molecules in solution Microsampling techniques

近期论文

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Synthesis and Spectral Characterization of Benzo[6,7] [1,5]diazocino[2,1-a]isoindol-12-(14H)-one DerivativesBassin, J., Anagani, B., Benham, C., Goyal, M., Hashemian , M. & Gerhard, U. 23 Jul 2016 In : Molecules. 21, 8, p. 967-979 13 p. Small molecule recognition of mephedrone using an anthracene molecular clipKellett, K., Broome, J. H., Zloh, M., Kirton, S. B., Fergus, S., Gerhard, U., Stair, J. L. & Wallace, K. J. 2016 In : Chemical Communications. 52, 47, p. 7474-7477 4 p. Direct Ionization of Solid-Phase Microextraction Fibers for Quantitative Drug Bionalysis: From Peripheral Circulation to Mass Spectrometry DetectionSheelan, A., Michael, T., Neil, S., Murnane, D. & Gerhard, U. 2015 In : Analytical Chemistry. 87, 1, p. 754-759 The Khat and Meow Meow Tale: Teaching the Relevance of Chemistry through Novel Recreational DrugsFergus, S., Kellett, K. & Gerhard, U. 2015 In : Journal of Chemical Education. 92, 5, p. 843-848 NK1 antagonists based on seven membered lactam scaffoldsElliott, J. M., Carlson, E. J., Chcchi, G. G., Dirat, O., Dominguez, M., Gerhard, U., Jelley, R., Jones, A. B., Kurtz, M. M., Tsao, K. I. & Wheeldon, A. 1 Jun 2006 In : Bioorganic and Medicinal Chemistry Letters. 16, 11, p. 2929-2932 4 p. A New Pyridazine Series of GABAA α5 LigandsVan Niel, M. B., Wilson, K., Adkins, C. H., Atack, J. R., Castro, J. L., Clarke, D. E., Fletcher, S., Gerhard, U., Mackey, M. M., Malpas, S., Maubach, K., Newman, R., O'Connor, D., Pillai, G. V., Simpson, P. B., Thomas, S. R. & MacLeod, A. M. 22 Sep 2005 In : Journal of Medicinal Chemistry. 48, 19, p. 6004-6011 8 p. H-1 NMR study of the conformation and absolute stereochemistry of two spirocyclic NK-1 antagonistsHerbert, R. H., Gerhard, U., Mortishire-Smith, R. J., Thomas, S. R. & Hollingworth, G. Aug 2005 In : Magnetic Resonance in Chemistry. 43, 8, p. 658-661 4 p. Aryl sulfones: A new class of γ-secretase inhibitorsTeall, M., Oakley, P., Harrison, T., Shaw, D., Kay, E., Elliott, J., Gerhard, U., Castro, J. L., Shearman, M., Ball, R. G. & Tsou, N. N. 16 May 2005 In : Bioorganic and Medicinal Chemistry Letters. 15, 10, p. 2685-2688 4 p. Fractionlynx for mass directed purification of metabolites: an alternative tool to get a metabolite into a NMR magnetGunn, D., Kingston, J., Thomas, S. R., Mortishire-Smith, R. J. & Gerhard, U. 2005 1 p. Open-access high-resolution mass spectrometry in early drug discoveryThomas, S. R. & Gerhard, U. Aug 2004 In : Journal of Mass Spectrometry. 39, 8, p. 942-948 7 p. Accelerated metabolite identification by "Extraction-NMR"Gerhard, U., Thomas, S. & Mortishire-Smith, R. 14 Jul 2003 In : Journal of Pharmaceutical and Biomedical Analysis. 32, 3, p. 531-538 8 p. Metabolite identification in drug discoveryWatt, A. P., Mortishire-Smith, R. J., Gerhard, U. & Thomas, S. R. 1 Jan 2003 In : Current Opinion in Drug Discovery and Development. 6, 1, p. 57-65 9 p. Synthesis and conformational dynamics of tricyclic pyridones containing a fused seven-membered ringGibson, K. R., Hitzel, L., Mortishire-Smith, R. J., Gerhard, U., Jelley, R. A., Reeve, A. J., Rowley, M., Nadin, A. & Owens, A. P. 27 Dec 2002 In : Journal of Organic Chemistry. 67, 26, p. 9354-9360 7 p. Identification of metabolites of a substance P (NK1 receptor) antagonist in rat hepatocytes and rat plasmaHop, C. E. C. A., Wang, Y., Kumar, S., Elipe, M. V. S., Raab, C. E., Dean, D. C., Poon, G. K., Keohane, C-A., Strauss, J., Chiu, S-H. L., Curtis, N., Elliott, J., Gerhard, U., Locker, K., Morrison, D., Mortishire-Smith, R., Watt, A. P. & Evans, D. C. 1 Jan 2002 p. 87-88 2 p. Identification of metabolites of a substance P (Neurokinin 1 receptor) antagonist in rat hepatocytes and rat plasmaHop, C. E. C. A., Wang, Y., Kumar, S., Elipe, M. V. S., Raab, C. E., Dean, D. C., Poon, G. K., Keohane, C-A., Strauss, J., Chiu, S-H. L., Curtis, N., Elliott, J., Gerhard, U., Locker, K., Morrison, D., Mortishire-Smith, R., Thomas, S., Watt, A. P. & Evans, D. C. 1 Jan 2002 In : Drug Metabolism and Disposition. 30, 8, p. 937-943 7 p. Neighboring group participation of the indole nucleus: An unusual DAST-mediated rearrangerment reactionHallett, D. J., Gerhard, U., Goodacre, S. C., Hitzel, L., Sparey, T. J., Thomas, S., Rowley, M. & Ball, R. G. 11 Aug 2000 In : Journal of Organic Chemistry. 65, 16, p. 4984-4993 10 p. Aromatic compounds from the liverwort Plagiochila spinulosaRycroft, D. S., Srivastava, D. L., Cole, W. J., Ifeadike, P., Kimbu, S. F., Singh, J., Connolly, J. D., Thom, C., Gerhard, U., Organ, A. J., Smith, R. J., Hughes, M. & Harrison, L. J. 10 Apr 1999 In : Phytochemistry. 50, 7, p. 1159-1165 7 p. Neighbouring Group Participation of the Indole Nucleus: An Unusual DAST Mediated Rearrangement Reaction Monitored by Low Temperature NMR SpectroscopyGerhard, U., Goodacre, S. C., Hallett, D. J., Rowley, M., Sparey, T. J. & Thomas, S. R. 1999 Synthesis of conformationally constrained analogues of BRL32872: Determination of stereochemistry and related pharmacological propertiesSouchet, M., Forest, M-C., Cheval, B., Rouanet, S., Faivre, J-F., Bril, A., Gerhard, U. & Smith, R. J. 5 Aug 1997 In : Bioorganic and Medicinal Chemistry Letters. 7, 15, p. 1989-1994 6 p. Ligands which bind weakly to vancomycin: Studies by 13C NMR spectroscopyPearce, C. M., Williams, D. H. & Gerhard, U. 1 Jan 1995 In : Journal of the Chemical Society, Perkin Transactions 2. 1, p. 159-162 4 p.