Hutter, Victoria - University of Hertfordshire - Department of Pharmacy, Pharmacology and Postgraduate Medicine

个人简介

Victoria obtained her MPharm and PhD at the University of Nottingham. She previously worked as an early development and formulation scientist in the Pharmaceutical Industry and as a clinical Pharmacist in the NHS. She started as a lecturer in Pharmaceutics and Pharmacy Practice at the University of Hertfordshire in January 2012. Her current research interests include in vitro modeling of inhaled therapeutics, with a particular focus on the role of drug transporters on permeability across the respiratory mucosa. She is also investigating biopharmaceutical aspects of other biological barriers, namely of the skin and gastro-intestinal tract and collaborating with other groups to determine cellular toxicity of nanoparticles and novel chemical entities.

研究领域

In vitro epithelial modelling (lung, intestine, skin) Development and characterisation of novel epithelial in vitro models In vitro-in vivo correlations Drug absorption/permeability mechanisms Drug-transporter interactions ABC and SLC transporter systems

近期论文

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In Vitro Cell Models for Ophthalmic Drug Development ApplicationsShafaie, S., Hutter, V., Cook, M. T., Brown, M. & Chau, D. Y. S. Apr 2016 In : BioResearch Open Access. 5, 1, p. 94-108Article Digoxin net secretory transport in bronchial epithelial cell layers is not exclusively mediated by P-glycoprotein/MDR1Hutter, V., Chau, D. Y. S., Hilgendorf, C., Brown, A., Cooper, A., Zann, V., Pritchard, D. I. & Bosquillon, C. Jan 2014 In : European Journal of Pharmaceutics and Biopharmaceutics. 86, 1, p. 74-82 9 p.Article Evaluation of layers of the rat airway epithelial cell line RL-65 for permeability screening of inhaled drug candidates.Hutter, V., Hilgendorf, C., Cooper, A., Zann, V., Pritchard, D. & Bosquillon, C. 29 Sep 2012 In : European Journal of Pharmaceutical Sciences. 47, 2, p. 481-489 9 p.Article Tissue transglutaminase (TG-2) modified amniotic membrane: a novel scaffold for biomedical applicationsChau, D. Y. S., Brown, S. V., Mather, M. L., Hutter, V., Tint, N. L., Dua, H. S., Rose, F. R. A. J. & Ghaemmaghami, A. M. Aug 2012 In : Biomedical Materials. 7, 4, 14 p., 045011Article The effect of processing variables on structural and mechanical properties of supercritical CO2 foamed scaffolds for tissue engineeringWhite, L., Hutter, V., Tai, H. Y., Howdle, S. & Shakesheff, K. Jan 2012 In : Acta Biomaterialia. 8, 1, p. 61-71 11 p.Article Interaction of inhaled therapeutics with drug transporters in Calu-3 cell layersHutter, V., Hilgendorf, C., Brown, A., Cooper, A., Zann, V., Pritchard, D. & Bosquillon, C. 2012Abstract Interactions of inhaled drugs with active transport mechanisms in bronchial epithelial cell layers in vitroHutter, V., Hilgendorf, C., Zann, V., Cooper, A., Pritchard, D. & Bosquillon, C. 2012Abstract Expression and functionality of P-glycoprotein in human bronchial epithelial cells in vitroHutter, V., Hilgendorf, C., Cooper, A., Zann, V., Pritchard, D. & Bosquillon, C. Sep 2011 In : European Respiratory Journal. 38, Supp 55, p. 142 P843Meeting abstract Development of a novel rat airway epithelial cell culture model for permeability screeningHutter, V., Hilgendorf, C., Cooper, A., Zann, V., Pritchard, D. & Bosquillon, C. 2011 p. 62 1 p.Abstract Evaluation of P-glycoprotein in drug trafficking across human bronchial epithelial cell culture modelsHutter, V. 2011 p. 22 1 p.Abstract P-glycoprotein does not play a significant role in 3H-digoxin transport in Calu-3 human bronchial epithelial cell monolayersHutter, V., Hilgendorf, C., Zann, V., Cooper, A., Pritchard, D. & Bosquillon, C. 2011Abstract Characterisation of ATP-binding cassette (ABC) transporters in the Calu-3 human bronchial epithelial cell culture modelHutter, V., Hilgendorf, C., Brown, A., Cooper, A., Zann, V., Pritchard, D. & Bosquillon, C. Oct 2010 In : Journal of Pharmacy and Pharmacology. 62, 10, p. 1225-1226 1 p.Meeting abstract Controlling the morphology and mechanical properties of supercritical fluid foamed scaffoldsWhite, L., Hutter, V., Howdle, S. & Shakesheff, K. 2010 p. 1503-1504 1 p.Abstract Evaluation of the rat airway epithelial RL-65 cell lin as a novel in vitro model for screening inhaled drug candidatesHutter, V., Tang, N., Zann, V., Cooper, A., Pritchard, D. & Bosquillon, C. 2010 p. 1230-1232 1 p.Abstract