Chau, David - University of Hertfordshire - Department of Pharmacy, Pharmacology and Postgraduate Medicine

个人简介

David originally trained as a chemical engineer before gaining an interest in biotechnology which resulted in the completion of a BEng and MSc, respectively, from the University of Birmingham. Thereafter, he gained his PhD under the guidance of Professor Martin Griffin (Nottingham Trent/Aston University) in the field of Tissue Engineering and Biomaterials which cumulated in the publication of several papers and the award of a worldwide patent. Following on, David pursued his research interests as a Postdoctoral Research Fellow under Professor Kevin Shakesheff (University of Nottingham) in Tissue Engineering/Advanced Drug Delivery before joining the Cell and Organism Engineering Laboratory of Professor Alan Tunnacliffe (University of Cambridge). In essence, David's research interests focuses on biotechnology- the application of the life sciences to the fields of engineering, medicine and technology- in particular their application to regenerative medicine and drug delivery. David's previous research has focused on tissue engineering and biomaterial development with emphasis on skin, the eye and the brain. In contrast, his most recent research has centred upon the development of a desiccation-tolerant mammalian cell line with a view for exploitation in long-term storage and biotechnological applications. David has experience of working at both academia and the industrial interface and maintains an extensive professional network accordingly. David is a firm believer in the concept of “to make things better, you first need to know how it works” and the application of “benchside-to-bedside” technology. As such, he aims to build upon his expertise in tissue engineering and drug delivery to develop more accurate and robust in-vitro-in-vivo-like models that may be exploited for drug development

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Hack 04/16: Digital Hack Lab JournalProust, A., Borstrock, S., Bloomfield, M., Cureton, P., Carta, S., Sopeoglou, E., Chau, D., Illner, A., De Main, N., Polydorou, D., Adams, R., Lindley, J., Beaufoy, J., Brownhill, P., McGonigal, S. & Lovegrove, N. Apr 2016 University of Hertfordshire. Park, R. & Bloomfield, M. (eds.). University of Hertfordshire, p. 24-27Chapter (peer-reviewed) In Vitro Cell Models for Ophthalmic Drug Development ApplicationsShafaie, S., Hutter, V., Cook, M. T., Brown, M. & Chau, D. Y. S. Apr 2016 In : BioResearch Open Access. 5, 1, p. 94-108Article An Overview of Tissue Engineering as an Alternative for Toxicity AssessmentGarrod, M. & Chau, D. Y. S. 30 Jan 2016 In : Journal of Pharmacy & Pharmaceutical Sciences. 19, 1, p. 31-71 40 p.Article Determination of Water Content in Dehydrated Mammalian Cells Using Terahertz Pulsed Imaging: A Feasibility StudyChau, D., Dennis, A., Lin, H., Zeitler, J. A. & Tunnacliffe, A. 26 Aug 2015 In : Current Pharmaceutical Biotechnology. 17, 2, p. 200-207 8 p.Article A technique to enhance the desiccation tolerance of mammalian cells: exploitation of novel proteins from Deinococcus radioduransTundidor, I., Patel, P. & Chau, D. 2015 In : European Cells and Materials (ECM).Meeting abstract Cross-linking of collagen I by tissue transglutaminase provides a promising biomaterial for promoting bone healingFortunati, D., Chau, D. Y. S., Wang, Z., Collighan, R. J. & Griffin, M. Jul 2014 In : Amino Acids. 46, 7, p. 1751-1761Article Digoxin net secretory transport in bronchial epithelial cell layers is not exclusively mediated by P-glycoprotein/MDR1Hutter, V., Chau, D. Y. S., Hilgendorf, C., Brown, A., Cooper, A., Zann, V., Pritchard, D. I. & Bosquillon, C. Jan 2014 In : European Journal of Pharmaceutics and Biopharmaceutics. 86, 1, p. 74-82 9 p.Article The development of a 3D immunocompetent model of human skinChau, D. Y. S., Johnson, C., MacNeil, S., Haycock, J. W. & Ghaemmaghami, A. M. Sep 2013 In : Biofabrication. 5, 3, 17 p., 035011Article Improving treatment of stroke through nanotechnologyNicholls, F., Gorenkova, N., Bible, E., Franco, C., Chau, D. Y. S., Tolias, C., Shakesheff, K., West, J. L. & Modo, M. 2013 The Textbook of Nanoneuroscience and Nanoneurosurgery. Kateb, B. & Heiss, J. D. (eds.). CRC Press, p. 283-298 16 p.Chapter (peer-reviewed) Neo-vascularization of the stroke cavity by implantation of human neural stem cells on VEGF-releasing PLGA microparticlesBible, E., Qutachi, O., Chau, D. Y. S., Alexander, M. R., Shakesheff, K. M. & Modo, M. Oct 2012 In : Biomaterials. 33, 30, p. 7435-7446 11 p.Article Severe conjunctivochalasis in association with classic type Ehlers-Danlos syndromeWhitaker, J. K., Alexander, P., Chau, D. Y. S. & Tint, N. L. 3 Sep 2012 In : BMC Ophthalmology. 12, 3 p., 47Article Tissue transglutaminase (TG-2) modified amniotic membrane: a novel scaffold for biomedical applicationsChau, D. Y. S., Brown, S. V., Mather, M. L., Hutter, V., Tint, N. L., Dua, H. S., Rose, F. R. A. J. & Ghaemmaghami, A. M. Aug 2012 In : Biomedical Materials. 7, 4, 14 p., 045011Article Tissue transglutaminase treatment leads to concentration-dependent changes in dendritic cell phenotype - implications for the role of transglutaminase in coeliac diseaseDalleywater, W. J., Chau, D. Y. S. & Ghaemmaghami, A. M. 16 Apr 2012 In : BMC Immunology. 13, 10 p., 20Article Combination of Injectable Multiple Growth Factor-Releasing Scaffolds and Cell Therapy as an Advanced Modality to Enhance Tissue NeovascularizationSaif, J., Schwarz, T. M., Chau, D. Y. S., Henstock, J., Sami, P., Leicht, S. F., Hermann, P. C., Alcala, S., Mulero, F., Shakesheff, K. M., Heeschen, C. & Aicher, A. Oct 2010 In : Arteriosclerosis, Thrombosis, and Vascular Biology. 30, 10, p. 1897-1904 8 p.Article The visualisation of vitreous using surface modified poly(lactic-co-glycolic acid) microparticlesChau, D. Y. S., Tint, N. L., Collighan, R. J., Griffin, M., Dua, H. S., Shakesheff, K. M. & Rose, F. R. A. J. May 2010 In : British Journal of Ophthalmology. 94, 5, p. 648-653 6 p.Article Laminin and Fibronectin Treatment Leads to Generation of Dendritic Cells with Superior Endocytic CapacityGarcia-Nieto, S., Johal, R. K., Shakesheff, K. M., Emara, M., Royer, P-J., Chau, D. Y. S., Shakib, F. & Ghaemmaghami, A. M. 19 Apr 2010 In : PLoS ONE. 5, 4, 10 p., 10123Article Transplantation of Human NSCs on VEGF-Releasing Microparticle Scaffolds in a Stroke ModelBible, E., Chau, D. Y. S., Alexander, M. R., Price, J., Shakesheff, K. M. & Modo, M. 2010 In : Cell Transplantation. 19, 3, p. 331-332 2 p.Meeting abstract The support of neural stem cells transplanted into stroke-induced brain cavities by PLGA particlesBible, E., Chau, D. Y. S., Alexander, M. R., Price, J., Shakesheff, K. M. & Modo, M. Jun 2009 In : Biomaterials. 30, 16, p. 2985-2994 10 p.Article The effect of delivery via narrow-bore needles on mesenchymal cellsAgashi, K., Chau, D. Y. S. & Shakesheff, K. M. Jan 2009 In : Regenerative Medicine. 4, 1, p. 49-64 16 p.Article Attachment of stem cells to scaffold particles for intra-cerebral transplantationBible, E., Chau, D. Y. S., Alexander, M. R., Price, J., Shakesheff, K. M. & Modo, M. 2009 In : Nature Protocols. 4, 10, p. 1440-1453 14 p.Article