个人简介

Degree in Pharmacy from Trinity College Dublin. PhD in Pharmaceutical Technology from the University of London (King's College London). Teaching Fellow in Pharmaceutics (2005-2008) (King's College London) Lecturer in Pharmaceutics (2008-2010) at King's College London. Principal Lecturer in Airways Pharmaceutics University of Hertfordshire (2010)

研究领域

Inhaled drug delivery In vitro product testing and modelling Physical chemistry Crystallization Particle technology and control of the solid state Industrial pharmaceutical development Pharmaceutical analytical chemistry

I am a pharmaceutical technologist with a particular interest in drug delivery to the airways including the lung, nose and the mouth-throat cavities. My academic interests lie in using chemical engineering, physical and analytical chemistry to understand the link between patient physiology and drug targetting. This extends to developing formulation analysis tools to aid identification of medicines and formulation performance. The focus of my research in recent years has been in achieving improvments in specificity of localised respiratory and topical drug delivery. This has extended to investigations into patient use of inhaled therapies and has led to a number of collaborations with clinicians and pharmaceutical companies in the last 5 years on PhD and post-doctoral projects as well as collaborative commercially-funded research.

近期论文

查看导师新发文章 （温馨提示：请注意重名现象，建议点开原文通过作者单位确认）

Establishing the importance of oil-membrane interactions on the transmembrane diffusion of physicochemically diverse compoundsNajib, O. N., Martin, G. P., Kirton, S., Sallam, A-S. & Murnane, D. 15 Jun 2016 In : International Journal of Pharmaceutics. 506, 1-2, p. 429 437 p.Article Interaction of Formulation and Device Factors Determine the In Vitro Performance of Salbutamol Sulphate Dry Powders for InhalationMuddle, J., Murnane, D., Parisini, I., Brown, M., Page, C. & Forbes, B. Nov 2015 In : International journal of pharmaceutical compounding. 104, 11, p. 3861-9 9 p.Article Formulation pre-screening of inhalation powders using computational atom-atom systematic search methodRamachandran, V., Murnane, D., Hammond, R. B., Pickering, J., Roberts, K. J., Soufian, M., Forbes, B., Jaffari, S., Martin, G. P., Collins, E. & Pencheva, K. 5 Jan 2015 In : Molecular Pharmaceutics. 12, 1, p. 18-33 16 p.Article Direct Ionization of Solid-Phase Microextraction Fibers for Quantitative Drug Bionalysis: From Peripheral Circulation to Mass Spectrometry DetectionSheelan, A., Michael, T., Neil, S., Murnane, D. & Gerhard, U. 2015 In : Analytical Chemistry. 87, 1, p. 754-759Article Evidence for the existence of powder sub-populations in micronized materials: Aerodynamic size-fractions of aerosolized powders possess distinct physicochemical propertiesJaffari, S., Forbes, B., Collins, E., Khoo, J., Martin, G. P. & Murnane, D. Dec 2014 In : Pharmaceutical Research. 31, 12, p. 3251-3264Article Potential of a cyclone prototype spacer to improve in vitro dry powder deliveryParisini, I., Cheng, S. J., Symons, D. & Murnane, D. May 2014 In : Pharmaceutical Research. 31, 5, p. 1133-1145Article Dynamics of aerosol size during inhalation: Hygroscopic growth of commercial nebulizer formulationsHaddrell, A. E., Davies, J. F., Miles, R. E. H., Reid, J. P., Dailey, L. A. & Murnane, D. 10 Mar 2014 In : International Journal of Pharmaceutics. 463, 1, p. 50-61 12 p.Article Assessment of a cyclone-type spacer device for use in dry powder inhalationParisini, I., Cheng, S. J., Symons, D. D., Brown, M., Kostrzewski, A. & Murnane, D. Aug 2013 In : Journal of Aerosol Medicine and Pulmonary Drug Delivery. 26, 4, p. A5 1 p., 11Meeting abstract The effect of aerodynamic particle size and solid state disorder on salmeterol xinafoate deposition from pressurised metered dose and dry powder inhaler formulationsJaffari, S., Sandhu, G., Martin, G. P., Forbes, B., Collins, E. & Murnane, D. Aug 2013 In : Journal of Aerosol Medicine and Pulmonary Drug Delivery. 26, 4, p. A237 1 p.Meeting abstract Rapid characterisation of the inherent dispersibility of respirable powders using dry dispersion laser diffractionJaffari, S., Forbes, B., Collins, E., Barlow, D. J., Martin, G. P. & Murnane, D. Apr 2013 In : International Journal of Pharmaceutics. 447, 1-2, p. 124-131Article Nitrogen-14 Nuclear Quadrupole Resonance Spectroscopy: a powerful new analytical methodology for medicines authentication and counterfeit antimalarial analysisBarras, J., Murnane, D., Althoefer, K., Assi, S., Rowe, M. I. D., Poplett, I. J. F., Kyriakidou, G. & Smith, J. A. S. 5 Feb 2013 In : Analytical Chemistry. 85, 5, p. 2746-2753Article Concordance, adherence or competence – device use and therapeutic outcomes in older patientsMurnane, D. 2013 In : Regulatory Rapporteur. 10, 7, p. 10-11Article Formation and measurement of process induced disorder during the manufacture of inhalation medicinesRoyall, P. G., Woodhead, B., Tang, S. J., Martin, G. P., Stockton, B. M. & Murnane, D. 1 Jul 2011 In : Journal of Drug Delivery Science and Technology. 21, 4, p. 311-318 8 p.Article Characterization of latent heat-releasing phase change materials for dermal therapiesWood, D. G., Brown, M., Jones, S. A. & Murnane, D. 28 Apr 2011 In : Journal of Physical Chemistry C. 115, 16, p. 8369-8375 7 p.Article Transiently supersaturated solutions from the dissolution of amorphous powders for topical drug deliveryPalmer, I. A., Jones, S. A., Murnane, D., Traynor, M. J., Moss, G. & Brown, M. Jun 2010 In : Journal of Pharmacy and Pharmacology. 62, 6, p. 795 1 p.Meeting abstract Dry Powder Formulations for Inhalation of Fluticasone Propionate and Salmeterol Xinafoate MicrocrystalsMurnane, D., Martin, G. P. & Marriott, C. Feb 2009 In : Journal of Pharmaceutical Sciences. 98, 2, p. 503-515 13 p.Article Investigations into the formulation of metered dose inhalers of salmeterol xinafoate and fluticasone propionate microcrystalsMurnane, D., Martin, G. P. & Marriott, C. Oct 2008 In : Pharmaceutical Research. 25, 10, p. 2283-2291 9 p.Article Polymorphic control of inhalation microparticles prepared by crystallizationMurnane, D., Marriott, C. & Martin, G. P. 1 Sep 2008 In : International Journal of Pharmaceutics. 361, 1-2, p. 141-149 9 p.Article In situ and Ex situ analysis of salmeterol xinafoate microcrystal formation from poly(ethylene glycol) 400 - Water cosolvent mixturesMurnane, D., Marriott, C. & Martin, G. P. Jun 2008 In : Crystal Growth & Design. 8, 6, p. 1855-1862 8 p.Article Comparison of salmeterol xinafoate microparticle production by conventional and novel antisolvent crystallizationMurnane, D., Marriott, C. & Martin, G. P. May 2008 In : European Journal of Pharmaceutics and Biopharmaceutics. 69, 1, p. 94-105 12 p.Article