Baydoun, Anwar - University of Hertfordshire - Department of Pharmacy, Pharmacology and Postgraduate Medicine

个人简介

Anwar Baydoun is an expert in Cardiovascular Pharmacology. An accomplished researcher in the field of cell signalling, applying his work to understanding physiological and pathophysiological mechanisms that may generate novel targets for drug development. He is most widely known for his work on nitric oxide and cationic amino acid transporters but also researches into the mechanisms that regulate the differentiation of stem cells into cardiomyocytes as well as those that regulate the process of vascular calcification in kidney and/or cardiovascular disease states. He is a Fellow of the British Pharmacological Society and currently Professor of Pharmacology at the University of Hertfordshire. He is also the Associate Dean Research in the School of Life and Medical Sciences and the Head of Research Degrees in Health and Human Sciences Research Institute. He collaborates extensively with clinicians and with Pharmaceutical industries in developing in vitro models for drug screening and/or disease states. Present Positions 2005- Present Professor of Pharmacology, School of Life and Medical Sciences Associate Dean Research, School of Life and Medical Sciences Head of Research Degrees, Health and Human Sciences Previous Positions 2002-2005 Reader in Molecular Pharmacology 1998-2002 Senior Lecturer in Biosciences, University of Hertfordshire 1997-1998 British Heart Foundation Research Fellow, King’s College London 1994-1997 British Heart Foundation Intermediate Fellow, King’s College London 1989-1994 Postdoctoral Research Fellow, King's College London 1987-1989 Postdoctoral Research Fellow, University of Bath

研究领域

Cardiovascular Pharmacology and Pathologies Nitric Oxide Signalling Cell & Molecular Biology Cationic amino acid transporters Vascular calcification Stem cells Cell signalling

近期论文

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Lactobacillus rhamnosus GG conditioned media modulates acute reactive oxygen species and nitric oxide in J774 murine macrophagesNanjundaiah, Y., Wright, D., O’Hare, W., Baydoun, A., Ali, Z., Khaled, Z. & Sarker, M. 7 Mar 2016 In : Biochemistry and Biophysics Reports. 6, p. 68-75 8 p., doi:10.1016/j.bbrep.2016.03.003Article 2014G-quadruplex formation of FXYD1 pre-mRNA indicates the possiblity of regulating expression of its protein productDhayan, H., Baydoun, A. R. & Kukol, A. 15 Oct 2014 In : Archives of Biochemistry and Biophysics. 560, p. 52-58Article 2013Human uraemic serum displays calcific potential in vitro that increases with advancing chronic kidney diseasePatidar, A., Singh, D., Winocour, P., Farrington, K. & Baydoun, A. R. Mar 2013 In : Clinical Science. 125, p. 237-245Article 2012Post-transcriptional divergence in the regulation of CAT-2A, CAT-2B and iNOS expression by dexamethasone in vascular smooth muscle cellsThakur, S. & Baydoun, A. R. 2012 In : Amino Acids. 43, 2, p. 667-676Article 2010Cell Culture TechniquesBaydoun, A. R. (ed.) Mar 2010 Principles and Techniques of Biochemistry and Molecular Biology . Wilson, K. & Walker, J. (eds.). 7th ed. Cambridge University Press, p. 38-72Chapter (peer-reviewed)2009Aspirin induces apoptosis in mesenchymal stem cells requiring Wnt/beta-catenin pathwayDeng, L., Hu, S., Baydoun, A. R., Chen, J., Chen, X. & Cong, X. 2009 In : Cell Proliferation. 42, 6, p. 721-730Article 2008Lysophosphatidic acid protects mesenchymal stem cells against hypoxia and serum deprivation-induced apoptosisChen, J., Baydoun, A. R., Xu, R., Deng, L., Liu, X., Zhu, W., Shi, L., Cong, X., Hu, S. & Chen, X. Jan 2008 In : Stem Cells. 26, 1, p. 135-45 11 p.Article 2007Inhibition of angiogenic tubule formation and induction of apoptosis in human endothelial cells by the selective cyclooxygenase-2 inhibitor 5-bromo-2-(4-fluorophenyl)-3-(methylsulfonyl) thiophene (DuP-697)Churchman, A., Baydoun, A. R. & Hoffman, R. 2007 In : European Journal of Pharmacology. 573, 1-3, p. 176-183Article 2006Cannabinoid signalling in TNF-alpha induced IL-8 releaseMormina, M. E., Thakur, S., Molleman, A., Whelan, C. J. & Baydoun, A. R. 2006 In : European Journal of Pharmacology. 540, p. 183-190Article y+ LAT-1 mediates transport of the potent and selective iNOS inhibitor, GW274150, in control J774 macrophagesBaydoun, A. R., Bertran, J., Thakur, S., Dawson, J., Palacin, M. & Knowles, R. G. 2006 In : Amino Acids. 31, 2, p. 101-109Article 2005Rate of transport of L-arginine is independent of the expression of inducible nitric oxide synthase in HEK 293 cellsCui, Z., Tuladhar, R., Hart, S. L., Marber, M. S., Pearson, J. D. & Baydoun, A. R. 2005 In : Nitric Oxide: Biology and Chemistry. 12, 1, p. 21-30Article 2003Role of L-citrulline transport in nitric oxide synthesis in rat aortic smooth muscle cells activated with LPS and interferon-Wileman, S. M., Mann, G. E., Pearson, J. D. & Baydoun, A. R. 2003 In : British Journal of Pharmacology. 140, 1, p. 179-185Article 2001Signal transduction of cannabinoid CB1 receptors in a smooth muscle cell lineBegg, M., Baydoun, A. R., Parsons, M. & Molleman, A. 2001 In : Journal of Physiology. 531, 1, p. 95-104Article 2000Nitric oxide-induced cardioprotection in cultured rat ventricular myocytesRakhit, R. D., Edwards, R. J., Mockridge, J. W., Baydoun, A. R., Wyatt, A. W., Mann, G. E. & Marber, M. S. 2000 In : American Journal of Physiology - Heart and Circulatory Physiology. 278Article 1999Differential regulation of L-arginine transport and nitric oxide synthase induction in cultured smooth muscle cellsBaydoun, A. R., Wileman, S. M., Wheeler-Jones, C. P. D., Marber, M. S., Mann, G. E., Pearson, J. D. & Closs, E. I. 1999 In : Biochemical Journal. 344, p. 265-272Article In vitro and in vivo TNFa synthesis modulation by methylguanidine, an uremic catabolyteAutore, G., Marzocco, S., Sorrentino, R., Mirone, V. G., Baydoun, A. R. & Pinto, A. 1999 In : Life Sciences. 65, 11Article Polyamine regulation of nitric oxide production in LPS-activated macrophagesMorgan, D. M. L. & Baydoun, A. R. (ed.) 1999 Biologically active amines in food: Biologically active amines in food processing and amines produced by bacteria, and polyamines and tumour growth. Bardocz, S., Koninkx, J., Grillo, M. & White, A. (eds.). Luxembourg: European Communities, Vol. 3, p. 115-126 (COST 917 Proceedings; vol. 3)Conference contributionTransmembrane signalling mechanisms regulating expression of cationic amino acid transporters and inducible nitric oxide synthase in rat vascular smooth muscle cellsBaydoun, A. R., Wileman, S. M., Wheeler-Jones, C. P. D., Marber, M. S., Mann, G. M., Pearson, J. D. & Closs, E. I. 1999 In : Biochemical Journal. 344, 1, p. 265-72Article 1998Inhibition of ornithine decarboxylase potentiates nitric oxide production in LPS-activated J774 cellsBaydoun, A. R. & Morgan, D. M. L. 1998 In : British Journal of Pharmacology. 125, 7, p. 1511-1516Article Mechanisms of acute vasodilator response to bacterial lipopolysaccharide in the rat coronary microcirculationCannon, T. R., Mann, G. E. & Baydoun, A. R. 1998 In : British Journal of Pharmacology. 123, 4, p. 637-644Article