Scotton, Chris - University of Exeter

个人简介

BA(hons), University of Cambridge MA, University of Cambridge PhD, Cancer Research UK

研究领域

Dr Scotton gives an overview of his research in the video below, filmed at the Living Systems Institute Symposium in March 2016.

近期论文

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Davies GF, Greenhough B, Hobson-West P, Kirk R, et al (2016). Developing a collaborative agenda for humanities and social scientific research on laboratory animal science and welfare. PLoS One Abstract. Full text. Article has an altmetric score of 37 Smoktunowicz N, Platé M, Ortiz-Stern A, D'Antongiovanni V, Robinson E, Chudasama V, Caddick S, Scotton CJ, Jarai G, Chambers RC, et al (2016). TGFβ upregulates PAR-1 expression and signalling responses in A549 lung adenocarcinoma cells. Oncotarget Abstract. Author URL. Full text. Jayasinghe SN, Auguste J, Scotton CJ (2015). Platform Technologies for Directly Reconstructing 3D Living Biomaterials. Adv Mater, 27(47), 7794-7799. Abstract. Author URL. Full text. Article has an altmetric score of 2 Smoktunowicz N, Alexander RE, Franklin L, Williams AE, Holman B, Mercer PF, Jarai G, Scotton CJ, Chambers RC (2015). The anti-fibrotic effect of inhibition of TGFβ-ALK5 signalling in experimental pulmonary fibrosis in mice is attenuated in the presence of concurrent γ-herpesvirus infection. Dis Model Mech, 8(9), 1129-1139. Abstract. Author URL. Full text. Baliga RS, Scotton CJ, Trinder SL, Chambers RC, MacAllister RJ, Hobbs AJ (2014). Intrinsic defence capacity and therapeutic potential of natriuretic peptides in pulmonary hypertension associated with lung fibrosis. Br J Pharmacol, 171(14), 3463-3475. Abstract. Author URL. Kallis YN, Scotton CJ, Mackinnon AC, Goldin RD, Wright NA, Iredale JP, Chambers RC, Forbes SJ (2014). Proteinase activated receptor 1 mediated fibrosis in a mouse model of liver injury: a role for bone marrow derived macrophages. PLoS One, 9(1). Abstract. Author URL. Mercer PF, Williams AE, Scotton CJ, José RJ, Sulikowski M, Moffatt JD, Murray LA, Chambers RC (2014). Proteinase-activated receptor-1, CCL2, and CCL7 regulate acute neutrophilic lung inflammation. Am J Respir Cell Mol Biol, 50(1), 144-157. Abstract. Author URL. Article has an altmetric score of 5 Datta A, Alexander R, Sulikowski MG, Nicholson AG, Maher TM, Scotton CJ, Chambers RC (2013). Evidence for a functional thymic stromal lymphopoietin signaling axis in fibrotic lung disease. J Immunol, 191(9), 4867-4879. Abstract. Author URL. Article has an altmetric score of 1 Scotton CJ, Hayes B, Alexander R, Datta A, Forty EJ, Mercer PF, Blanchard A, Chambers RC (2013). Ex vivo micro-computed tomography analysis of bleomycin-induced lung fibrosis for preclinical drug evaluation. European Respiratory Journal, 42(6), 1633-1645. Abstract. Author URL. Article has an altmetric score of 1 Chambers RC, Scotton CJ (2012). Coagulation cascade proteinases in lung injury and fibrosis. Proc Am Thorac Soc, 9(3), 96-101. Abstract. Author URL. Jenkins G, Blanchard A, Borok Z, Bradding P, Ehrhardt C, Fisher A, Hirani N, Johnson S, Königshoff M, Maher TM, et al (2012). In search of the fibrotic epithelial cell: opportunities for a collaborative network. Thorax, 67(2), 179-182. Abstract. Author URL. Scotton CJ, Chambers RC (2012). Innate immunity in lung fibrosis: a therapeutic role for surfactant protein D?. Am J Respir Crit Care Med, 185(5), 471-473. Author URL. Scotton CJ (2011). A breath of fresh air for tissue engineering?. Materials Today, 14(5), 212-216. Abstract. Article has an altmetric score of 1 Jayasinghe SN, Warnes G, Scotton CJ (2011). Bio-electrosprayed living composite matrix implanted into mouse models. Macromol Biosci, 11(10), 1364-1369. Abstract. Author URL. Article has an altmetric score of 1 Datta A, Scotton CJ, Chambers RC (2011). Novel therapeutic approaches for pulmonary fibrosis. Br J Pharmacol, 163(1), 141-172. Abstract. Author URL. Cho WS, Duffin R, Howie SE, Scotton CJ, Wallace WA, Macnee W, Bradley M, Megson IL, Donaldson K (2011). Progressive severe lung injury by zinc oxide nanoparticles; the role of Zn2+ dissolution inside lysosomes. Part Fibre Toxicol, 8 Abstract. Author URL. Scotton CJ, Chambers RC (2010). Bleomycin revisited: towards a more representative model of IPF?. Am J Physiol Lung Cell Mol Physiol, 299(4), L439-L441. Author URL. Atzori L, Lucattelli M, Scotton CJ, Laurent GJ, Bartalesi B, De Cunto G, Lunghi B, Chambers RC, Lungarella G (2009). Absence of proteinase-activated receptor-1 signaling in mice confers protection from fMLP-induced goblet cell metaplasia. Am J Respir Cell Mol Biol, 41(6), 680-687. Abstract. Author URL. Aguilar S, Scotton CJ, McNulty K, Nye E, Stamp G, Laurent G, Bonnet D, Janes SM (2009). Bone marrow stem cells expressing keratinocyte growth factor via an inducible lentivirus protects against bleomycin-induced pulmonary fibrosis. PLoS One, 4(11). Abstract. Author URL. Scotton CJ, Krupiczojc MA, Kö, nigshoff M, Mercer PF, Lee YCG, Kaminski N, Morser J, Post JM, Maher TM, et al (2009). Increased local expression of coagulation factor X contributes to the fibrotic response in human and murine lung injury. J Clin Invest, 119(9), 2550-2563.