Richardson, Sarah - University of Exeter

个人简介

Sarah Richardson’s career in type 1 diabetes research began in 2007 when she joined Professor Noel Morgan’s group at the University of Exeter Medical School. Prior to this her postdoctoral work was in the field of apoptosis based at both the University of Sheffield and the Walter and Eliza Hall Institute in Melbourne. She utilises two unique cohorts of type 1 diabetes patient pancreas samples and her research is centred around developing a clearer understanding of the disease processes by which beta cells are targeted and destroyed. She has a particular interest in the role that enteroviruses may play in the disease pathogenesis. Her current research projects are aimed at confirming whether enterovirus can be detected in the pancreas of patients, and enhancing knowledge of the pathogenic signaling mechanisms involved in the recruitment and activation of immune cells. The success of this work enabled her to gain a Diabetes Research Wellness Foundation (DRWF) Non-Clinical Research Fellowship, a Juvenile Diabetes Research Foundation (JDRF) Career Development Award, an nPOD Junior Investigator Award and she was an Innovators in Diabetes participant with Diabetes UK (2010-2013). She is an enthusiastic and pro-active member of both the nPOD-V, where she is also a Task leader, and the EU FP7 PEVNET networks.

研究领域

Dr Richardson gives an overview of her research into the role enteroviruses may have in causing Type 1 diabetes in the video below, filmed at the Living Systems Symposium 2016.

近期论文

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Wagner FF, Lundh M, Kaya T, McCarren P, Zhang YL, Chattopadhyay S, Gale JP, Galbo T, Fisher SL, Meier BC, et al (2016). An Isochemogenic Set of Inhibitors to Define the Therapeutic Potential of Histone Deacetylases in β-Cell Protection. ACS Chem Biol, 11(2), 363-374. Abstract. Author URL. Article has an altmetric score of 1 Jmii H, Halouani A, Elmastour F, Ifie E, Richardson SJ, Sane F, Mokni M, Aouni M, Hober D, Jaïdane H, et al (2016). Central nervous system infection following vertical transmission of Coxsackievirus B4 in mice. Pathog Dis Abstract. Author URL. Full text. Leete P, Willcox A, Krogvold L, Dahl-Jørgensen K, Foulis AK, Richardson SJ, Morgan NG (2016). Differential Insulitic Profiles Determine the Extent of β-Cell Destruction and the Age at Onset of Type 1 Diabetes. Diabetes, 65(5), 1362-1369. Abstract. Author URL. Full text. Article has an altmetric score of 175 Richardson SJ, Rodriguez-Calvo T, Gerling IC, Mathews CE, Kaddis JS, Russell MA, Zeissler M, Leete P, Krogvold L, Dahl-Jørgensen K, et al (2016). Islet cell hyperexpression of HLA class I antigens: a defining feature in type 1 diabetes. Diabetologia, 59(11), 2448-2458. Abstract. Author URL. Full text. Article has an altmetric score of 25 Laiho JE, Oikarinen M, Richardson SJ, Frisk G, Nyalwidhe J, Burch TC, Morris MA, Oikarinen S, Pugliese A, Dotta F, et al (2016). Relative sensitivity of immunohistochemistry, multiple reaction monitoring mass spectrometry, in situ hybridization and PCR to detect Coxsackievirus B1 in A549 cells. Journal of Clinical Virology, 77, 21-28. Full text. Article has an altmetric score of 1 Russell MA, Taniguchi K, Richardson SJ, Morgan NG (2016). STAT6, a novel regulator of beta cell viability, is reduced in islets of patients with recent-onset Type 1 diabetes. DIABETIC MEDICINE, 33, 21-21. Author URL. Leete P, Richardson SJ, Krogvold L, Dahl-Jorgensen K, Foulis AK, Morgan NG (2016). Understanding differential rates of progression to Type 1 diabetes in humans: study of the relationship between age at diagnosis and the underlying pancreatic pathology. DIABETIC MEDICINE, 33, 56-56. Author URL. Richardson SJ, Horwitz MS (2016). miR, miR in the Cell, Does the Virus Control Them All?. Diabetes, 65(4), 823-825. Full text. Article has an altmetric score of 5 Russell MA, Richardson SJ, Morgan NG (2015). Both components of MHC class 1 are hyper-expressed in pancreatic islets during human Type 1 diabetes but the transcriptional regulator, NLRC5, is not. DIABETIC MEDICINE, 32, 9-9. Author URL. Krogvold L, Edwin B, Buanes T, Frisk G, Skog O, Anagandula M, Korsgren O, Undlien D, Eike MC, Richardson SJ, et al (2015). Detection of a low-grade enteroviral infection in the islets of langerhans of living patients newly diagnosed with type 1 diabetes. Diabetes, 64(5), 1682-1687. Abstract. Author URL. Full text. Article has an altmetric score of 56 Willcox A, Richardson SJ, Walker LSK, Wong FS, Morgan NG, Gillespie KM (2015). Differential architecture and germinal centre formation in pancreatic lymph nodes from donors with recent onset and long-standing Type 1 diabetes. DIABETIC MEDICINE, 32, 65-65. Author URL. Marroqui L, Lopes M, dos Santos RS, Grieco FA, Roivainen M, Richardson SJ, Morgan NG, Op de Beeck A, Eizirik DL (2015). Differential cell autonomous responses determine the outcome of coxsackievirus infections in murine pancreatic α and β cells. Elife, 4 Abstract. Author URL. Article has an altmetric score of 2 Leete P, Richardson SJ, Krogvold L, Willcox A, Dahl-Jorgensen K, Foulis AK, Morgan NG (2015). Low B-lymphocyte numbers within the insulitic lesion correlates with an elevated proportion of persisting beta cells and later onset of disease in patients with Type 1 diabetes. DIABETIC MEDICINE, 32, 63-63. Author URL. Taniguchi K, Russell MA, Richardson SJ, Morgan NG (2015). The subcellular distribution of cyclin-D1 and cyclin-D3 within human islet cells varies according to the status of the pancreas donor. Diabetologia, 58(9), 2056-2063. Abstract. Article has an altmetric score of 6 Taniguchi K, Russell MA, Richardson SJ, Morgan NG (2015). The subcellular distribution of cyclin-D1 and cyclin-D3 within human islet cells varies according to the status of the pancreas donor. Diabetologia Abstract. Full text. Article has an altmetric score of 6 Arif S, Leete P, Nguyen V, Marks K, Nor NM, Estorninho M, Kronenberg-Versteeg D, Bingley PJ, Todd JA, Guy C, et al (2014). Blood and islet phenotypes indicate immunological heterogeneity in type 1 diabetes. Diabetes, 63(11), 3835-3845. Abstract. Author URL. Full text. Article has an altmetric score of 17 Richardson SJ, Leete P, Dhayal S, Russell MA, Oikarinen M, Laiho JE, Svedin E, Lind K, Rosenling T, Chapman N, et al (2014). Detection of enterovirus in the islet cells of patients with type 1 diabetes: what do we learn from immunohistochemistry? Reply to Hansson SF, Korsgren S, Pontén F et al [letter]. Diabetologia, 57(3), 647-649. Author URL. Full text. Richardson SJ, Rodriguez-Calvo T, Oikarinen M, Laiho JE, Kusmartseva I, Campbell-Hompson M, Baj A, Toniolo A, von Herrath M, Hyoty H, et al (2014). Enteroviral infection in human type 1 diabetes: correlative evidence from multiple tissue sources in nPOD samples. DIABETOLOGIA, 57, S125-S126. Author URL. Morgan NG, Richardson SJ (2014). Enteroviruses as causative agents in type 1 diabetes: loose ends or lost cause?. Trends Endocrinol Metab, 25(12), 611-619. Abstract. Author URL. Full text. Article has an altmetric score of 11 Richardson SJ, Leete P, Dhayal S, Russell MA, Oikarinen M, Laiho JE, Svedin E, Lind K, Rosenling T, Chapman N, et al (2014). Evaluation of the fidelity of immunolabelling obtained with clone 5D8/1, a monoclonal antibody directed against the enteroviral capsid protein, VP1, in human pancreas. Diabetologia, 57(2), 392-401. Abstract. Full text.