Pawlak, Robert - University of Exeter

个人简介

Prof. Pawlak graduated from the faculty of Medicine, Medical University of Bialystok, Poland (1994) and received a PhD in Medical Sciences from the same University (1997). Prior to his current appointment at Exeter he studied neuronal plasticity and animal behaviour in Poland (Medical University of Bialystok), Japan (Hamamatsu University), USA (The Rockefeller University) and in the UK (University of Leicester). Prof. Pawlak is the first author or a co-author of over 50 publications. Broad research specialisms One fundamental question in modern neurobiology is how memories and emotions are formed in the brain. Our lab is interested in cellular mechanisms involved in experience-induced neuronal plasticity underlying learning, fear and anxiety. We study these phenomena using a combination of genetic, cell biological, pharmacological, electrophysiological and behavioural approaches. Qualifications 1994 - Diploma of Physician, Faculty of Medicine, Medical University of Bialystok, Poland 1997 - PhD, Medical University of Bialystok, Poland

研究领域

Prof. Pawlak is interested in cellular mechanisms involved in experience-induced neuronal plasticity underlying learning, fear and anxiety. Psychological stress induces neuronal responses that can be either adaptive and directed toward maintaining homeostasis, or maladaptive leading to severe behavioural abnormalities. Understanding neural bases of stress, fear and anxiety is of an immense importance to modern society. Anxiety disorders affect about 25% of adults at least once in their lives, and make a huge social, family and welfare impact. The most dramatic form, posttraumatic stress disorder (PTSD) is characterized by cognitive impairment, depression, fear, anxiety, and may eventually lead to suicide. Understanding of the neural mechanisms of PTSD and other anxiety disorders could reduce the personal and societal impact through development of more efficient therapies. How is fear and anxiety formed in the brain? Fear memories are encoded as changes in strength of synaptic connections, a process called plasticity. However, the molecular mechanisms that facilitate stress-induced behavioural abnormalities remain unclear. Two brain regions critically involved in fear responses are the amygdala and the hippocampus. We study stress-regulated genes in these areas using a combination of genetic, cell biological, pharmacological, electrophysiological and behavioural approaches. Prof. Pawlak has particular interests in the role that extracellular proteases, their receptors (PARs) and the extracellular matrix play in experience-induced plasticity in the limbic system. Another area of interest is the involvement of ephrins and their receptors Eph’s in these processes. He uses an interdisciplinary approach to better understand the role of the above molecules in the central nervous system physiology

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Patel KA, Oram RA, Mcdonald TJ, Hudson M, Colclough K, Ellard S, Weedon MN, Pearson EZ, Hattersley AT (2016). Classifying the unclassified using Type 1 diabetes genetic risk score: patients with young onset diabetes who are islet autoantibody negative and have preserved c-peptide. DIABETIC MEDICINE, 33, 188-189. Author URL. Patel KA, Laver T, Johnson M, Sanders T, Shepherd M, Ellard S, Flanagan S, Hattersley AT, Weedon MN (2016). RFX6 is a new MODY gene. DIABETIC MEDICINE, 33, 33-33. Author URL. Patel KA, Oram RA, Flanagan SE, De Franco E, Colclough K, Shepherd M, Ellard S, Weedon MN, Hattersley AT (2016). Type 1 Diabetes Genetic Risk Score: a Novel Tool to Discriminate Monogenic and Type 1 Diabetes. Diabetes, 65(7), 2094-2099. Full text. Article has an altmetric score of 14 Hall MH, Magalska A, Malinowska M, Ruszczycki B, Czaban I, Patel S, Ambrozek-Latecka M, Zolocinska E, Broszkiewicz H, Parobczak K, et al (2016). Localization and regulation of PML bodies in the adult mouse brain. Brain Struct Funct, 221(5), 2511-2525. Abstract. Author URL. Article has an altmetric score of 1 Baple EL, Maroofian R, Chioza BA, Izadi M, Cross HE, Al-Turki S, Barwick K, Skrzypiec A, Pawlak R, Wagner K, et al (2014). Mutations in KPTN cause macrocephaly, neurodevelopmental delay, and seizures. Am J Hum Genet, 94(1), 87-94. Abstract. Author URL. Article has an altmetric score of 7 Tsilibary E, Tzinia A, Radenovic L, Stamenkovic V, Lebitko T, Mucha M, Pawlak R, Frischknecht R, Kaczmarek L (2014). Neural ECM proteases in learning and synaptic plasticity. Prog Brain Res, 214, 135-157. Abstract. Author URL. Bourgognon JM, Schiavon E, Salah-Uddin H, Skrzypiec AE, Attwood BK, Shah RS, Patel SG, Mucha M, John Challiss RA, Forsythe ID, et al (2013). Regulation of neuronal plasticity and fear by a dynamic change in PAR1-G protein coupling in the amygdala. Mol Psychiatry, 18(10), 1136-1145. Abstract. Author URL. Article has an altmetric score of 1 Skrzypiec AE, Shah RS, Schiavon E, Baker E, Skene N, Pawlak R, Mucha M (2013). Stress-induced lipocalin-2 controls dendritic spine formation and neuronal activity in the amygdala. PLoS One, 8(4). Abstract. Author URL. Full text. Article has an altmetric score of 1 Attwood BK, Patel S, Pawlak R (2012). Ephs and ephrins: emerging therapeutic targets in neuropathology. Int J Biochem Cell Biol, 44(4), 578-581. Abstract. Author URL. McGeachie AB, Skrzypiec AE, Cingolani LA, Letellier M, Pawlak R, Goda Y (2012). β3 integrin is dispensable for conditioned fear and hebbian forms of plasticity in the hippocampus. Eur J Neurosci, 36(4), 2461-2469. Abstract. Author URL. Article has an altmetric score of 1 Mucha M, Skrzypiec AE, Schiavon E, Attwood BK, Kucerova E, Pawlak R (2011). Lipocalin-2 controls neuronal excitability and anxiety by regulating dendritic spine formation and maturation. Proc Natl Acad Sci U S A, 108(45), 18436-18441. Abstract. Author URL. Article has an altmetric score of 3 Attwood BK, Bourgognon JM, Patel S, Mucha M, Schiavon E, Skrzypiec AE, Young KW, Shiosaka S, Korostynski M, Piechota M, et al (2011). Neuropsin cleaves EphB2 in the amygdala to control anxiety. Nature, 473(7347), 372-375. Abstract. Author URL. Article has an altmetric score of 11 Poulin B, Butcher A, McWilliams P, Bourgognon JM, Pawlak R, Kong KC, Bottrill A, Mistry S, Wess J, Rosethorne EM, et al (2010). The M3-muscarinic receptor regulates learning and memory in a receptor phosphorylation/arrestin-dependent manner. Proc Natl Acad Sci U S A, 107(20), 9440-9445. Abstract. Author URL. Article has an altmetric score of 7 Skrzypiec AE, Maiya R, Chen Z, Pawlak R, Strickland S (2009). Plasmin-mediated degradation of laminin gamma-1 is critical for ethanol-induced neurodegeneration. Biol Psychiatry, 66(8), 785-794. Abstract. Author URL. Skrzypiec AE, Buczko W, Pawlak R (2008). Tissue plasminogen activator in the amygdala: a new role for an old protease. J Physiol Pharmacol, 59 Suppl 8, 135-146. Abstract. Author URL. Pawlak R, Rao BS, Melchor JP, Chattarji S, McEwen B, Strickland S (2005). Tissue plasminogen activator and plasminogen mediate stress-induced decline of neuronal and cognitive functions in the mouse hippocampus. Proc Natl Acad Sci U S A, 102(50), 18201-18206. Abstract. Author URL.