Murphy, Therese - University of Exeter

个人简介

In 2005, upon completion of an Honours Degree in Genetics from Trinity College Dublin, Dr Murphy was awarded a Health Research Board Ph.D. scholarship in Molecular Medicine and joined the Prostate Molecular Oncology group in the Institute of Molecular Medicine, Trinity College Dublin. The main focus of her Ph.D. was investigating the role of DNA methylation in prostate cancer development, with a hope to identify potential markers of the disease. After completion of her PhD in 2010, she was awarded a Craig Dobbins Newman fellowship in Mental Health Research by University College Dublin, in collaboration with Professor Kevin Malone, based on her scientific proposal to examine how epigenetic mechanisms may contribute to suicide risk. In May 2013, she joined Prof. Mill’s Complex Disease Epigenetics Group, University of Exeter, as a Research Fellow investigating epigenetic changes in depression and other complex diseases. In September 2015 Dr Murphy was appointed as Lecturer (Education and Research). Broad research specialisms Epigenetic/ DNA methylation analysis Gene expression analysis Depression Suicidality Epigenetic changes of immune/inflammatory genes in depression and inflammatory related disorders. Polymorphisms in DNA methyltranserase genes and suicide risk Epigenetic changes associated with prostate cancer Qualifications 2015 - present - PGCAP, University of Exeter 2010 - PhD, Trinity College Dublin 2007 - P.Grad.Dip Statistics, Trinity College Dublin 2005- BA (Honors) Genetics, Trinity College Dublin

研究领域

Dr Murphy is particularly interested in understanding the role of epigenetics (specifically DNA methylation) in depression and suicide. She also has an interest in interactions between inflammatory/immune phenotypes, mental health/psychological stress and the epigenome.

近期论文

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McDermott E, Ryan EJ, Tosetto M, Gibson D, Burrage J, Keegan D, Byrne K, Crowe E, Sexton G, Malone K, et al (2016). DNA Methylation Profiling in Inflammatory Bowel Disease Provides New Insights into Disease Pathogenesis. J Crohns Colitis, 10(1), 77-86. Abstract. Author URL. Full text. Article has an altmetric score of 7 Hannon E, Spiers H, Viana J, Pidsley R, Burrage J, Murphy TM, Troakes C, Turecki G, O'Donovan MC, Schalkwyk LC, et al (2016). Methylation QTLs in the developing brain and their enrichment in schizophrenia risk loci. Nat Neurosci, 19(1), 48-54. Abstract. Author URL. Full text. Article has an altmetric score of 104 Murphy TM, O'Donovan A, Mullins N, O'Farrelly C, McCann A, Malone K (2015). Anxiety is associated with higher levels of global DNA methylation and altered expression of epigenetic and interleukin-6 genes. Psychiatr Genet, 25(2), 71-78. Abstract. Author URL. Article has an altmetric score of 3 McDermott E, Murphy T, Sexton G, Keegan D, Doherty G, Cullen G, Mulcahy H, Ryan E (2015). Global DNA methylation in inflammatory bowel disease. IRISH JOURNAL OF MEDICAL SCIENCE, 184, S24-S25. Author URL. Fisher HL, Murphy TM, Arseneault L, Caspi A, Moffitt TE, Viana J, Hannon E, Pidsley R, Burrage J, Dempster EL, et al (2015). Methylomic analysis of monozygotic twins discordant for childhood psychotic symptoms. Epigenetics, 10(11), 1014-1023. Abstract. Author URL. Full text. Article has an altmetric score of 9 Murphy TM, Wong CC, Arseneault L, Burrage J, Macdonald R, Hannon E, Fisher HL, Ambler A, Moffitt TE, Caspi A, et al (2015). Methylomic markers of persistent childhood asthma: a longitudinal study of asthma-discordant monozygotic twins. Clin Epigenetics, 7 Abstract. Author URL. Full text. Article has an altmetric score of 5 Murphy TM, Tuzova AV, O Rourke CJ, O Meachair S, Greene C, Sullivan L, Thornhill J, Barrett C, Loftus B, Lynch T, et al (2015). Multigene methylation biomarker analysis in prostate cancer. Epigenetic Diagnosis and Therapy, 1(1), 19-27. Abstract. Murphy TM, Mill J (2014). Epigenetics in health and disease: Heralding the EWAS era. The Lancet, 383(9933), 1952-1954. Article has an altmetric score of 24 Fisher H, Murphy T, Arseneault L, Burrage J, Dempster E, Caspi A, Moffitt T, Mill J (2014). Genome-wide DNA methylation profiling in monozygotic twins discordant for psychotic symptoms at age 12. EARLY INTERVENTION IN PSYCHIATRY, 8, 57-57. Author URL. McDermott E, Rowan C, Murphy T, Byrne K, Doherty G, Cullen G, Mulcahy H, Ryan E (2014). Global DNA methylation in inflammatory bowel disease. JOURNAL OF CROHNS & COLITIS, 8, S342-S342. Author URL. Davies MN, Krause L, Bell JT, Gao F, Ward KJ, Wu H, Lu H, Liu Y, Tsai P-C, Collier DA, et al (2014). Hypermethylation in the ZBTB20 gene is associated with major depressive disorder. GENOME BIOLOGY, 15(4). Author URL. Article has an altmetric score of 47 Perry AS, O'Hurley G, Raheem OA, Brennan K, Wong S, O'Grady A, Kennedy AM, Marignol L, Murphy TM, Sullivan L, et al (2013). Gene expression and epigenetic discovery screen reveal methylation of SFRP2 in prostate cancer. Int J Cancer, 132(8), 1771-1780. Abstract. Author URL. Murphy TM, Mullins N, Ryan M, Foster T, Kelly C, McClelland R, O'Grady J, Corcoran E, Brady J, Reilly M, et al (2013). Genetic variation in DNMT3B and increased global DNA methylation is associated with suicide attempts in psychiatric patients. Genes Brain Behav, 12(1), 125-132. Abstract. Author URL. Article has an altmetric score of 2 O'Rourke CJ, Murphy TM, Hollywood D, Perry AS (2013). Mining methylome databases. Trends Genet, 29(2), 63-65. Author URL. Sullivan L, Murphy TM, Barrett C, Loftus B, Thornhill J, Lawler M, Hollywood D, Lynch T, Perry AS (2012). IGFBP7 promoter methylation and gene expression analysis in prostate cancer. J Urol, 188(4), 1354-1360. Abstract. Author URL. Article has an altmetric score of 1 Murphy TM, Sullivan L, Lane C, O'Connor L, Barrett C, Hollywood D, Lynch T, Lawler M, Perry AS (2011). In silico analysis and DHPLC screening strategy identifies novel apoptotic gene targets of aberrant promoter hypermethylation in prostate cancer. Prostate, 71(1), 1-17. Abstract. Author URL. Murphy TM, Ryan M, Foster T, Kelly C, McClelland R, O'Grady J, Corcoran E, Brady J, Reilly M, Jeffers A, et al (2011). Risk and protective genetic variants in suicidal behaviour: association with SLC1A2, SLC1A3, 5-HTR1B &NTRK2 polymorphisms. Behav Brain Funct, 7 Abstract. Author URL. Murphy TM, Perry AS, Lawler M (2008). The emergence of DNA methylation as a key modulator of aberrant cell death in prostate cancer. Endocr Relat Cancer, 15(1), 11-25. Abstract. Author URL. Murphy TM, Mullins N, Foster T, Kelly C, McClelland R, O'Grady J, Corcoran E, Brady J, Reilly M, Jeffers A, et al (2012). A Functional Dnmt3b Polymorphism is Associated with Suicide Attempt in Psychiatric Patients. Author URL. Murphy TM, Perry AS, O'Connor L, Lawler M (2007). A bioinformatics approach to identify candidate apoptotic genes which may be the subject of epigenetic control in prostate cancer. Author URL.