Mill, Jonathan - University of Exeter

个人简介

Jonathan is Professor of Epigenetics at the University of Exeter Medical School and also heads the Psychiatric Epigenetics group at the Institute of Psychiatry, King‘s College London. He graduated with a degree in Human Sciences from Oxford University, where he took a particular interest in cannibalism, before undertaking his PhD in psychiatric genetics at the Institute of Psychiatry. After spending three years as a Canadian Institutes of Health Research (CIHR) postdoctoral fellow at the University of Toronto, he returned to the Institute of Psychiatry to establish the Psychiatric Epigenetics group in the MRC Social, Genetic and Developmental Psychiatry Centre. He was appointed as Professor of Epigenetics at UEMS in September 2012. The research in Jonathan‘s group focuses primarily on the role of epigenetic processes in mediating the interplay between genes and the environment in common, complex disease phenotypes. Although their work is particularly focussed on neuropsychiatric phenotypes, their research spans the spectrum of biomedical disease phenotypes. Additional information can be found at www.epigenomicslab.com. Broad research specialisms Jonathan‘s group takes an integrated genetic-epigenetic approach to complex disease phenotypes, and has considerable experience in high-throughput epigenomic profiling. The recently took the lead on the first systematic genome-wide scan for DNA methylation changes associated with schizophrenia and bipolar disorder, and are currently funded to perform methylomic studies of schizophrenia, bipolar disorder, autism, alcoholism, and Alzheimer’s disorder. Their research aims to understand the role of functional epigenetic variation in mediating the interplay between genes and the environment in disease. Qualifications PhD Psychiatric Genetics (Institute of Psychiatry, King’s College London) BA Human Sciences (Oxford University)

研究领域

Sequencing the genome was only the first step in our quest to understand how genes are expressed and regulated. Sitting above the DNA sequence is a second layer of information (the 'epigenome') that regulates several genomic functions, including when and where genes are turned-on or -off. 'Epigenetics' refers to the reversible regulation of gene expression mediated principally through changes in DNA methylation and chromatin structure. Epigenetic processes are essential for normal cellular development and differentiation, and allow the regulation of gene function through non-mutagenic mechanisms. Unlike the DNA sequence, which is stable and strongly conserved, epigenetic processes can be tissue-specific, developmentally-regulated and dynamic. For example, mounting evidence suggests that epigenetic processes can be influenced by exposure to factors in the environment. Epigenetic dysfunction can explain numerous epidemiological, clinical, and molecular peculiarities associated with psychiatric disorders that are difficult to rectify using traditional gene- and environment-based approaches. These include the incomplete concordance between monozygotic (MZ) twins, a fluctuating disease course with periods of remission and relapse, periods of environmental sensitivity, sexual dimorphism, peaks of susceptibility to disease coinciding with major hormonal rearrangements, and parent-of-origin effects. Our group utilizes cutting-edge methods to explore the role of epigenetic processes in complex disease phenotypes, with a particular focus on neuropsychiatric disorders.

近期论文

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Lunnon KS, Mill J (In Press). Epigenetic studies in Alzheimer’s disease: current findings, caveats and considerations for future studies. Am. J. Med. Genet. B Neuropsychiatr Spiers H, Hannon E, Wells S, Williams B, Fernandes C, Mill J (2016). Age-associated changes in DNA methylation across multiple tissues in an inbred mouse model. Mech Ageing Dev, 154, 20-23. Abstract. Author URL. Article has an altmetric score of 6 Rijlaarsdam J, Pappa I, Walton E, Bakermans-Kranenburg MJ, Mileva-Seitz VR, Rippe RC, Roza SJ, Jaddoe VW, Verhulst FC, Felix JF, et al (2016). An epigenome-wide association meta-analysis of prenatal maternal stress in neonates: a model approach for replication. Epigenetics, 11(2), 140-149. Abstract. Author URL. Article has an altmetric score of 5 Hannon E, Dempster E, Viana J, Burrage J, Smith AR, Macdonald R, St Clair D, Mustard C, Breen G, Therman S, et al (2016). An integrated genetic-epigenetic analysis of schizophrenia: evidence for co-localization of genetic associations and differential DNA methylation. Genome Biol, 17(1). Abstract. Author URL. Full text. Article has an altmetric score of 124 Laing LV, Viana J, Dempster EL, Trznadel M, Trunkfield LA, Uren Webster TM, van Aerle R, Paull GC, Wilson RJ, Mill J, et al (2016). Bisphenol a causes reproductive toxicity, decreases dnmt1 transcription, and reduces global DNA methylation in breeding zebrafish (Danio rerio). Epigenetics, 11(7), 526-538. Abstract. Author URL. Full text. Article has an altmetric score of 17 Richardson TG, Shihab HA, Hemani G, Zheng J, Hannon E, Mill J, Carnero-Montoro E, Bell JT, Lyttleton O, McArdle WL, et al (2016). Collapsed methylation quantitative trait loci analysis for low frequency and rare variants. Hum Mol Genet Abstract. Author URL. McDermott E, Ryan EJ, Tosetto M, Gibson D, Burrage J, Keegan D, Byrne K, Crowe E, Sexton G, Malone K, et al (2016). DNA Methylation Profiling in Inflammatory Bowel Disease Provides New Insights into Disease Pathogenesis. J Crohns Colitis, 10(1), 77-86. Abstract. Author URL. Full text. Article has an altmetric score of 7 Walton E, Pingault JB, Cecil CA, Gaunt TR, Relton CL, Mill J, Barker ED (2016). Epigenetic profiling of ADHD symptoms trajectories: a prospective, methylome-wide study. Mol Psychiatry Abstract. Author URL. Article has an altmetric score of 21 Devall M, Roubroeks J, Mill J, Weedon M, Lunnon K (2016). Epigenetic regulation of mitochondrial function in neurodegenerative disease: New insights from advances in genomic technologies. Neurosci Lett, 625, 47-55. Abstract. Author URL. Full text. Article has an altmetric score of 11 Cecil CA, Smith RG, Walton E, Mill J, McCrory EJ, Viding E (2016). Epigenetic signatures of childhood abuse and neglect: Implications for psychiatric vulnerability. J Psychiatr Res, 83, 184-194. Abstract. Author URL. Article has an altmetric score of 2 Jeffries AR, Uwanogho DA, Cocks G, Perfect LW, Dempster E, Mill J, Price J (2016). Erasure and reestablishment of random allelic expression imbalance after epigenetic reprogramming. RNA, 22(10), 1620-1630. Abstract. Author URL. Full text. Article has an altmetric score of 17 Lunnon K, Hannon E, G Smith R, Dempster E, Wong C, Burrage J, Troakes C, Al-Sarraj S, Kepa A, Schalkwyk L, et al (2016). Erratum to: Variation in 5-hydroxymethylcytosine across human cortex and cerebellum [Genome Biol. 2016, 17, 27]. Genome Biology, 17(1). Lu AT, Hannon E, Levine ME, Hao K, Crimmins EM, Lunnon K, Kozlenkov A, Mill J, Dracheva S, Horvath S, et al (2016). Genetic variants near MLST8 and DHX57 affect the epigenetic age of the cerebellum. Nat Commun, 7 Abstract. Author URL. Full text. Article has an altmetric score of 5 Houtepen LC, Vinkers CH, Carrillo-Roa T, Hiemstra M, van Lier PA, Meeus W, Branje S, Heim CM, Nemeroff CB, Mill J, et al (2016). Genome-wide DNA methylation levels and altered cortisol stress reactivity following childhood trauma in humans. Nat Commun, 7 Abstract. Author URL. Article has an altmetric score of 34 Smith AR, Smith RG, Condliffe D, Hannon E, Schalkwyk L, Mill J, Lunnon K (2016). Increased DNA methylation near TREM2 is consistently seen in the superior temporal gyrus in Alzheimer's disease brain. Neurobiol Aging, 47, 35-40. Abstract. Author URL. Article has an altmetric score of 11 Cizmeci D, Dempster EL, Champion OL, Wagley S, Akman OE, Prior JL, Soyer OS, Mill J, Titball RW (2016). Mapping epigenetic changes to the host cell genome induced by Burkholderia pseudomallei reveals pathogen-specific and pathogen-generic signatures of infection. Sci Rep, 6 Abstract. Author URL. Article has an altmetric score of 8 Hannon E, Spiers H, Viana J, Pidsley R, Burrage J, Murphy TM, Troakes C, Turecki G, O'Donovan MC, Schalkwyk LC, et al (2016). Methylation QTLs in the developing brain and their enrichment in schizophrenia risk loci. NATURE NEUROSCIENCE, 19(1), 48-+. Author URL. Full text. Article has an altmetric score of 104 Wilmot B, Fry R, Smeester L, Musser ED, Mill J, Nigg JT (2016). Methylomic analysis of salivary DNA in childhood ADHD identifies altered DNA methylation in VIPR2. J Child Psychol Psychiatry, 57(2), 152-160. Abstract. Author URL. Article has an altmetric score of 13 Kumsta R, Marzi SJ, Viana J, Dempster EL, Crawford B, Rutter M, Mill J, Sonuga-Barke EJ (2016). Severe psychosocial deprivation in early childhood is associated with increased DNA methylation across a region spanning the transcription start site of CYP2E1. Transl Psychiatry, 6(6). Abstract. Author URL. Article has an altmetric score of 8 Saunderson EA, Spiers H, Mifsud KR, Gutierrez-Mecinas M, Trollope AF, Shaikh A, Mill J, Reul JM (2016). Stress-induced gene expression and behavior are controlled by DNA methylation and methyl donor availability in the dentate gyrus. Proc Natl Acad Sci U S A, 113(17), 4830-4835. Abstract.