Melzer, David - University of Exeter

个人简介

Dr David Melzer is Professor of Epidemiology and Public Health at the Medical School, University of Exeter, UK. His research interests are in the causes and consequences of chronic disease in later life. His group’s research programme includes analysis of genomic and conventional biomarkers, plus studies of medical treatment in later life. He trained in medicine in South Africa (graduating 1981), studied public health at the London School of Hygiene and completed his PhD at the University of Cambridge. He received a Harkness Fellowship in 1998, spent at the Guralnik laboratory at the US National Institute on Aging. He worked as an NHS consultant in Public Health Medicine in the early 1990s before becoming a full time academic. He was formerly Director of the Epidemiology for Policy Group, in the Department of Public Health and Primary Care, University of Cambridge. Prof. Melzer has received research support from the US National Institutes of Health, the Wellcome Trust, British Heart Foundation, the Medical Research Council, Age UK, NIHR and other funders. 1981 MB BCh Medicine and Surgery, University of Witwatersrand, South Africa 1987 MSc Community Medicine, London School of Hygiene and Tropical Medicine 1998 Fellow of the Faculty of Public Health Medicine 2006 PhD Public Health, Cambridge University

研究领域

First evidence (to the best of my knowledge) in a human population of splice ratio changes with advancing age (Aging cell, 2011) First evidence in older humans that CEBP-Beta expression is associated with muscle strength – concordant with a mouse model of macrophage mediated muscle repair (Aging Cell, 2012) First report of CCR2 expression in humans associated with cognitive impairment – concordant with mouse model of beta-amyloid phagocytosis in Alzheimer’s mouse model (Rejuvenation Research, 2012) The first longitudinal analysis of low vitamin D levels, showing association with later cognitive impairment in older people (Archives of Internal Medicine, 2010) First evidence of p16 (CDKN2a, 9p21) loci SNP associated with frailty – nearby loci later implicated in diabetes and cardiovascular disease (Mechanisms of Ageing & Development, 2007) The first studies linking environmental endocrine disrupting chemical BPA to adult disease in the general population (JAMA, 2008) with first longitudinal study (Circulation, 2012).

近期论文

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Huan T, Joehanes R, Schurmann C, Schramm K, Pilling LC, Peters MJ, Magi R, DeMeo D, O'Connor GT, Ferrucci L, et al (In Press). A Whole-Blood Transcriptome Meta-Analysis Identifies Gene Expression Signatures of Cigarette Smoking. Human Molecular Genetics Article has an altmetric score of 5 correa delgado, masoli, Bowman K, strain, Kuchel G, Walters K, Lafortune L, Brayne C, Melzer D, ble, et al (In Press). OUTCOMES OF TREATED HYPERTENSION AT AGES 80 YEARS AND OLDER: COHORT ANALYSIS OF 79,376 PATIENTS. Journal of the American Geriatrics Society Bowman K, Correa Delgado J, Henley W, Masoli J, Kos K, Brayne C, Thokala P, Lafortune L, Kuchel G, Ble A, et al (In Press). Obesity in Older People with and Without Conditions Associated with Weight Loss: Follow-up of 955,000 Primary Care Patients. J Gerontol a Biol Sci Med Sci Article has an altmetric score of 10 McCarthy S, Das S, Kretzschmar W, Delaneau O, Wood AR, Teumer A, Kang HM, Fuchsberger C, Danecek P, Sharp K, et al (2016). A reference panel of 64,976 haplotypes for genotype imputation. Nat Genet, 48(10), 1279-1283. Abstract. Author URL. Full text. Article has an altmetric score of 180 Lee BP, Pilling LC, Emond F, Flurkey K, Harrison DE, Yuan R, Peters LL, Kuchel GA, Ferrucci L, Melzer D, et al (2016). Changes in the expression of splicing factor transcripts and variations in alternative splicing are associated with lifespan in mice and humans. Aging Cell, 15(5), 903-913. Abstract. Author URL. Article has an altmetric score of 5 Ruth KS, Perry JR, Henley WE, Melzer D, Weedon MN, Murray A (2016). Events in Early Life are Associated with Female Reproductive Ageing: a UK Biobank Study. Sci Rep, 6 Abstract. Author URL. Full text. Article has an altmetric score of 1 Pilling LC, Joehanes R, Kacprowski T, Peters M, Jansen R, Karasik D, Kiel DP, Harries LW, Teumer A, Powell J, et al (2016). Gene transcripts associated with muscle strength: a CHARGE meta-analysis of 7,781 persons. Physiol Genomics, 48(1), 1-11. Abstract. Author URL. Article has an altmetric score of 19 Pilling LC, Atkins JL, Bowman K, Jones SE, Tyrrell J, Beaumont RN, Ruth KS, Tuke MA, Yaghootkar H, Wood AR, et al (2016). Human longevity is influenced by many genetic variants: evidence from 75,000 UK Biobank participants. Aging (Albany NY), 8(3), 547-560. Abstract. Author URL. Article has an altmetric score of 73 Atkins JL, Pilling LC, Ble A, Dutta A, Harries LW, Murray A, Brayne C, Robine JM, Kuchel GA, Ferrucci L, et al (2016). Longer-Lived Parents and Cardiovascular Outcomes: 8-Year Follow-Up in 186,000 U.K. Biobank Participants. J Am Coll Cardiol, 68(8), 874-875. Author URL. Article has an altmetric score of 487 Ble A, Hughes PM, Delgado J, Masoli JA, Bowman K, Zirk-Sadowski J, Mujica Mota RE, Henley WE, Melzer D (2016). Safety and Effectiveness of Statins for Prevention of Recurrent Myocardial Infarction in 12 156 Typical Older Patients: a Quasi-Experimental Study. J Gerontol a Biol Sci Med Sci Abstract. Author URL. Full text. Article has an altmetric score of 3 Mathur R, Ince PG, Minett T, Garwood CJ, Shaw PJ, Matthews FE, Brayne C, Simpson JE, Wharton SB (2015). A Reduced Astrocyte Response to β-Amyloid Plaques in the Ageing Brain Associates with Cognitive Impairment. PLOS ONE, 10(2), e0118463-e0118463. Article has an altmetric score of 4 Huan T, Esko T, Peters MJ, Pilling LC, Schramm K, Schurmann C, Chen BH, Liu C, Joehanes R, Johnson AD, et al (2015). A meta-analysis of gene expression signatures of blood pressure and hypertension. PLoS Genet, 11(3). Abstract. Author URL. Full text. Article has an altmetric score of 27 Ble A, Masoli JA, Barry HE, Winder RE, Tavakoly B, Henley WE, Kuchel GA, Valderas JM, Melzer D, Richards SH, et al (2015). Any versus long-term prescribing of high risk medications in older people using 2012 Beers Criteria: results from three cross-sectional samples of primary care records for 2003/4, 2007/8 and 2011/12. BMC Geriatr, 15 Abstract. Author URL. Full text. Article has an altmetric score of 6 Bowman K, Ble A, Delgado J, Melzer D (2015). CHRONIC KIDNEY DISEASE AS a RISK FACTOR FOR CARDIOVASCULAR EVENTS OR MORTALITY. GERONTOLOGIST, 55, 25-25. Author URL. Westra HJ, Arends D, Esko T, Peters MJ, Schurmann C, Schramm K, Kettunen J, Yaghootkar H, Fairfax BP, Andiappan AK, et al (2015). Cell Specific eQTL Analysis without Sorting Cells. PLoS Genet, 11(5). Abstract. Author URL. Article has an altmetric score of 11 Blackwell J, Harries LW, Pilling LC, Ferrucci L, Jones A, Melzer D (2015). Changes in CEBPB expression in circulating leukocytes following eccentric elbow-flexion exercise. Journal of Physiological Sciences, 65(1), 145-150. Abstract. Article has an altmetric score of 1 Blackwell J, Harries LW, Pilling LC, Ferrucci L, Jones A, Melzer D (2015). Changes in CEBPB expression in circulating leukocytes following eccentric elbow-flexion exercise. J Physiol Sci, 65(1), 145-150. Abstract. Author URL. Full text. Article has an altmetric score of 1 Holly AC, Grellscheid S, van de Walle P, Dolan D, Pilling LC, Daniels DJ, von Zglinicki T, Ferrucci L, Melzer D, Harries LW, et al (2015). Comparison of senescence-associated miRNAs in primary skin and lung fibroblasts. Biogerontology, 16(4), 423-434. Abstract. Author URL. Moore AZ, Ding J, Tuke MA, Wood A, Melzer D, Bandinelli S, Frayling T, Ferrucci L (2015). DISTRIBUTION OF MITOCHONDRIAL DNA HETEROPLASMY IN PARTICIPANTS OF THE INCHIANTI STUDY. GERONTOLOGIST, 55, 67-67. Author URL. Pfeiffer L, Wahl S, Pilling LC, Reischl E, Sandling JK, Kunze S, Holdt LM, Kretschmer A, Schramm K, Adamski J, et al (2015). DNA methylation of lipid-related genes affects blood lipid levels. Circ Cardiovasc Genet, 8(2), 334-342. Abstract.