Lunnon, Katie - University of Exeter

个人简介

Katie is a Senior Lecturer in Epigenetics at the University of Exeter Medical School, with a particular interest in dementia. Katie graduated with a BSc Honours degree in Biochemistry & Pharmacology (1st Class) from the University of Southampton in 2004. It was during this Batchelor's degree that Katie became fascinated by dementia, which naturally led on to her PhD studies in the CNS Inflammation Group at the University of Southampton under the supervision of Professor Hugh Perry. During her PhD she investigated the effect that systemic inflammation has on the brain, particularly in dementia. In 2008 Katie started a post-doctoral research position in the Department of Old Age Psychiatry in King's College London. In this role she identified peripheral changes that occur in the blood of people with Alzheimer's disease. Subsequently in 2011 Katie moved to the Social, Genetic and Developmental Psychiatry (SGDP) Centre also within King's College London to work in the Psychiatric Epigenetics Group. Here she combined techniques she had previously acquired, with cutting-edge methylomics technology to investigate the role of DNA methylation in late-onset Alzheimer's disease aetiology. This work represented the first high-throughput, genome-wide, cross-tissue methylomic study in Alzheimer's disease. Katie was appointed as a Lecturer at the University of Exeter Medical School, in June 2013, and became a Senior Lecturer in September 2015. Here the focus of her research surrounds investigating epigenetic mechanisms in dementia. Qualifications BSc Biochemistry & Pharmacology (1st Hons) (2004, Southampton) PhD Neuroscience (2008, Southampton) PGCAP (2010, King’s College London)

研究领域

Katie’s key research interests focus on the role of epigenetics in dementia. The scope of her research ranges from identifying new epigenetic biomarkers for Alzheimer’s disease, to identifying novel epigenetic marks in Alzheimer’s brain

近期论文

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Lunnon KS, Mill J (In Press). Epigenetic studies in Alzheimer’s disease: current findings, caveats and considerations for future studies. Am. J. Med. Genet. B Neuropsychiatr Devall M, Roubroeks J, Mill J, Weedon M, Lunnon K (2016). Epigenetic regulation of mitochondrial function in neurodegenerative disease: New insights from advances in genomic technologies. Neurosci Lett, 625, 47-55. Abstract. Author URL. Full text. Article has an altmetric score of 11 Lu AT, Hannon E, Levine ME, Hao K, Crimmins EM, Lunnon K, Kozlenkov A, Mill J, Dracheva S, Horvath S, et al (2016). Genetic variants near MLST8 and DHX57 affect the epigenetic age of the cerebellum. Nat Commun, 7 Abstract. Author URL. Full text. Article has an altmetric score of 5 Guerreiro R, Escott-Price V, Darwent L, Parkkinen L, Ansorge O, Hernandez DG, Nalls MA, Clark L, Honig L, Marder K, et al (2016). Genome-wide analysis of genetic correlation in dementia with Lewy bodies, Parkinson's and Alzheimer's diseases. Neurobiol Aging, 38, 214.e7-214.10. Abstract. Author URL. Full text. Article has an altmetric score of 19 Smith AR, Smith RG, Condliffe D, Hannon E, Schalkwyk L, Mill J, Lunnon K (2016). Increased DNA methylation near TREM2 is consistently seen in the superior temporal gyrus in Alzheimer's disease brain. Neurobiol Aging, 47, 35-40. Abstract. Author URL. Article has an altmetric score of 11 Marzi SJ, Meaburn EL, Dempster EL, Lunnon K, Paya-Cano JL, Smith RG, Volta M, Troakes C, Schalkwyk LC, Mill J, et al (2016). Tissue-specific patterns of allelically-skewed DNA methylation. Epigenetics, 11(1), 24-35. Abstract. Author URL. Full text. Article has an altmetric score of 18 Lunnon K, Hannon E, Smith RG, Dempster E, Wong C, Burrage J, Troakes C, Al-Sarraj S, Kepa A, Schalkwyk L, et al (2016). Variation in 5-hydroxymethylcytosine across human cortex and cerebellum. Genome Biol, 17 Abstract. Author URL. Full text. Article has an altmetric score of 12 Voyle N, Keohane A, Newhouse S, Lunnon K, Johnston C, Soininen H, Kloszewska I, Mecocci P, Tsolaki M, Vellas B, et al (2015). A Pathway Based Classification Method for Analyzing Gene Expression for Alzheimer's Disease Diagnosis. J Alzheimers Dis, 49(3), 659-669. Abstract. Author URL. Full text. Article has an altmetric score of 10 Devall M, Burrage J, Caswell R, Johnson M, Troakes C, Al-Sarraj S, Jeffries AR, Mill J, Lunnon K (2015). A comparison of mitochondrial DNA isolation methods in frozen post-mortem human brain tissue--applications for studies of mitochondrial genetics in brain disorders. Biotechniques, 59(4), 241-246. Abstract. Author URL. Full text. Article has an altmetric score of 2 Sood S, Gallagher IJ, Lunnon K, Rullman E, Keohane A, Crossland H, Phillips BE, Cederholm T, Jensen T, van Loon LJ, et al (2015). A novel multi-tissue RNA diagnostic of healthy ageing relates to cognitive health status. Genome Biol, 16 Abstract. Author URL. Full text. Article has an altmetric score of 368 Lunnon K, Smith RG, Cooper I, Greenbaum L, Mill J, Beeri MS (2015). Blood methylomic signatures of presymptomatic dementia in elderly subjects with type 2 diabetes mellitus. Neurobiology of Aging, 36(3), 1600.e1-1600.e4. Abstract. Article has an altmetric score of 2 Lunnon K, Smith RG, Cooper I, Greenbaum L, Mill J, Beeri MS (2015). Blood methylomic signatures of presymptomatic dementia in elderly subjects with type 2 diabetes mellitus. Neurobiol Aging, 36(3), 1600.e1-1600.e4. Abstract. Author URL. Full text. Article has an altmetric score of 2 Hannon E, Lunnon K, Schalkwyk L, Mill J (2015). Interindividual methylomic variation across blood, cortex, and cerebellum: implications for epigenetic studies of neurological and neuropsychiatric phenotypes. Epigenetics, 10(11), 1024-1032. Abstract. Author URL. Full text. Article has an altmetric score of 17 Nalls MA, Bras J, Hernandez DG, Keller MF, Majounie E, Renton AE, Saad M, Jansen I, Guerreiro R, Lubbe S, et al (2015). NeuroX, a fast and efficient genotyping platform for investigation of neurodegenerative diseases. Neurobiology of Aging, 36(3), 1605.e7-1605.e12. Article has an altmetric score of 11 Chiam JTW, Lunnon K, Voyle N, Proitsi P, Coppola G, Geschwind D, Nelson S, Johnston C, Soininen H, Kloszewska I, et al (2015). No Evidence to Suggest that the Use of Acetylcholinesterase Inhibitors Confounds the Results of Two Blood-Based Biomarker Studies in Alzheimer's Disease. Journal of Alzheimer's Disease, 47(3), 741-750. Abstract. Article has an altmetric score of 11 Proitsi P, Lee SH, Lunnon K, Keohane A, Powell J, Troakes C, Al-Sarraj S, Furney S, Soininen H, Kloszewska I, et al (2014). Alzheimer's disease susceptibility variants in the MS4A6A gene are associated with altered levels of MS4A6A expression in blood. Neurobiology of Aging, 35(2), 279-290. Abstract. Proitsi P, Lee SH, Lunnon K, Keohane A, Powell J, Troakes C, Al-Sarraj S, Furney S, Soininen H, Kloszewska I, et al (2014). Alzheimer's disease susceptibility variants in the MS4A6A gene are associated with altered levels of MS4A6A expression in blood. Neurobiol Aging, 35(2), 279-290. Abstract. Author URL. De Jager PL, Srivastava G, Lunnon K, Burgess J, Schalkwyk LC, Yu L, Eaton ML, Keenan BT, Ernst J, McCabe C, et al (2014). Alzheimer's disease: early alterations in brain DNA methylation at ANK1, BIN1, RHBDF2 and other loci. Nat Neurosci, 17(9), 1156-1163. Abstract. Author URL. Full text. Article has an altmetric score of 220 Killick R, Ribe EM, Al-Shawi R, Malik B, Hooper C, Fernandes C, Dobson R, Nolan PM, Lourdusamy A, Furney S, et al (2014). Clusterin regulates β-amyloid toxicity via Dickkopf-1-driven induction of the wnt-PCP-JNK pathway. Molecular Psychiatry, 19(1), 88-98. Abstract. Article has an altmetric score of 10 Condliffe D, Wong A, Troakes C, Proitsi P, Patel Y, Chouliaras L, Fernandes C, Cooper J, Lovestone S, Schalkwyk L, et al (2014). Cross-region reduction in 5-hydroxymethylcytosine in Alzheimer's disease brain. Neurobiology of Aging, 35(8), 1850-1854. Abstract.