Kos, Katarina - University of Exeter

个人简介

Dr Katarina Kos has a key interest in the field of Type 2 diabetes and its link with obesity and its complications. She leads the adipose tissue biology group at the University of Exeter with a special interest in adipose tissue physiology and obesity related disorders. Energy surplus leads to deposition of superfluous energy as fat/ triglycerides in fat/adipose tissue. Katarina believes that this is the most physiological and healthy way to deal with surplus calories. With time and due to a variety of predisposing factors adipose tissue can become stressed. Fat cells expand to the limits of their ability and new fat cells fail to be formed. The emerging dysfunction is characterised by inflammation of fat by infiltration of immune cells such as macrophages. The structural network of connective tissue into which fat cells are embedded also changes with obesity. It becomes rigid and scarred (fibrosed) not allowing fat cells to grow and expand. A key discovery of the last century is that fat tissue is not only storing lipids but also secreting hormones which regulate several metabolic functions, some of which they are key in appetite regulation such as the hormone leptin, and/or contribute to glucose regulation. Together with inflammation, secreted hormones of adipose tissue (known as adipokines) strongly contribute to insulin resistance and the development of diabetes. Dysfunctional fat tissue loses its ability to grow and expand, however in this setting, this is not of health benefit or leading necessarily to weight reduction. Continuation of surplus energy supplies requires storage of fats. As fat tissue is increasingly unable to deal with the demand, surplus lipids are deposited as inner abdominal fat tissue within organs and surrounding organs. Examples are the lipid deposition in the liver causing fatty liver disease,deposition in and around the heart causing weakening of the heart muscle and within the vascular walls of the arteries contributing to heart disease, stroke and dementia. Lipids are also increasingly found in the skeletal muscle which is not specific to us humans and we may more or less consciously observe in the mottling of the breakfast bacon. In the last few years it was demonstrated very convincingly that this process can be reversed by weight loss achieved by caloric restriction with or without weight loss surgery by which people with Type 2 diabetes can be at least temporarily cured from diabetes with the duration of the remission depending on the sustainability of weight loss. Current research interests of Katarina are to increase the understanding of the extracellular matrix proteins and their regulators which influence the healthy expansion of fat tissue. She is curious of whether dysfuntional fat changes such as fibrosis are reversible. She hopes to identify physiological barriers which stop us from losing weight. Clinically she would like to answer what make us dependent on calorie consumption and makes us to eat. Katarina has close collaborations with the vascular team, biophysics group, functional genomics team and has an interest in the cross talk of adipose tissue with insulin producing beta cells. Besides laboratory based studies she undertakes projects within the translational medicine framework supported and part of the Exeter NIHR clinical research facility (CRF). She is also exploring psychological issues of eating behaviour and interested in the nutritional impact on obesity complications such as dementia. Her NHS clinical work consists of a lead role in the hospital weight management service aimed at people with severe obesity and in preparation of weight loss surgery. She also consults patients with diabetes and endocrinological problems. Qualifications MBBS equivalent University of Munich MD Ludwig Maximillian University, Munich PhD Warwick University M Med Ed Warwick University

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McCulloch LJ, Rawling TJ, Sjöholm K, Franck N, Dankel SN, Price EJ, Knight B, Liversedge NH, Mellgren G, Nystrom F, et al (2015). COL6A3 is regulated by leptin in human adipose tissue and reduced in obesity. Endocrinology, 156(1), 134-146. Abstract. Article has an altmetric score of 1 McCulloch LJ, Rawling TJ, Sjöholm K, Franck N, Dankel SN, Price EJ, Knight B, Liversedge NH, Mellgren G, Nystrom F, et al (2015). COL6A3 is regulated by leptin in human adipose tissue and reduced in obesity. Endocrinology, 156(1), 134-146. Abstract. Author URL. Article has an altmetric score of 1 Aung MM, Gooding KM, Kos K, Shore AC (2015). Human, in vivo, microvascular actions of glucagon-like peptide 1 (GLP-1) and its analogues in health, obesity and well controlled Type 2 diabetes. DIABETIC MEDICINE, 32, 99-99. Author URL. Lourida I, Thompson-Coon J, Dickens CM, Soni M, Kuzma E, Kos K, Llewellyn DJ (2015). Parathyroid hormone, cognitive function and dementia: a systematic review. PLoS One, 10(5). Abstract. Author URL. Full text. Article has an altmetric score of 12 Littlejohns TJ, Kos K, Henley WE, Cherubini A, Ferrucci L, Lang IA, Langa KM, Melzer D, Llewellyn DJ (2015). Serum leptin and risk of cognitive decline in elderly italians. J Alzheimers Dis, 44(4), 1231-1239. Abstract. Author URL. Full text. Lawrence NS, O'Sullivan J, Parslow D, Javaid M, Adams RC, Chambers CD, Kos K, Verbruggen F (2015). Training response inhibition to food is associated with weight loss and reduced energy intake. Appetite, 95, 17-28. Abstract. Full text. Aung MM, Gooding KM, Haynes LJ, Kos K, Shore AC (2014). Do glucagon like peptide-1 analogues alter microvascular function in healthy lean individuals?. DIABETIC MEDICINE, 31, 52-52. Author URL. Littlejohns TJ, Henley WE, Lang IA, Annweiler C, Beauchet O, Chaves PH, Fried L, Kestenbaum BR, Kuller LH, Langa KM, et al (2014). Vitamin D and the risk of dementia and Alzheimer disease. Neurology, 83(10), 920-928. Abstract. Author URL. Full text. Article has an altmetric score of 918 Harries LW, McCulloch LJ, Holley JE, Rawling TJ, Welters HJ, Kos K (2013). A role for SPARC in the moderation of human insulin secretion. PLoS One, 8(6). Abstract. Author URL. Full text. Weedon MN, Ellard S, Prindle MJ, Caswell R, Allen HL, Oram R, Godbole K, Yajnik CS, Sbraccia P, Novelli G, et al (2013). An in-frame deletion at the polymerase active site of POLD1 causes a multisystem disorder with lipodystrophy. Nature Genetics, 45(8), 947-950. Abstract. Article has an altmetric score of 83 Weedon MN, Ellard S, Prindle MJ, Caswell R, Lango Allen H, Oram R, Godbole K, Yajnik CS, Sbraccia P, Novelli G, et al (2013). An in-frame deletion at the polymerase active site of POLD1 causes a multisystem disorder with lipodystrophy. Nat Genet, 45(8), 947-950. Abstract. Author URL. Article has an altmetric score of 83 Bowen AR, Whatmore J, Kos K, Welters HJ (2013). Role of non-canonical Wnt signalling in pancreatic beta cells. DIABETIC MEDICINE, 30, 17-17. Author URL. Alkhouli N, Mansfield J, Green E, Bell J, Knight B, Liversedge N, Tham JC, Welbourn R, Shore AC, Kos K, et al (2013). The mechanical properties of human adipose tissues and their relationships to the structure and composition of the extracellular matrix. Am J Physiol Endocrinol Metab, 305(12), E1427-E1435. Abstract. Author URL. Article has an altmetric score of 1 Soni M, Kos K, Lang IA, Jones K, Melzer D, Llewellyn DJ (2012). Vitamin D and cognitive function. Scand J Clin Lab Invest Suppl, 243, 79-82. Abstract. Author URL. Article has an altmetric score of 25 Kos K, Wong S, Tan BK, Kerrigan D, Randeva HS, Pinkney JH, Wilding JP (2011). Human RBP4 adipose tissue expression is gender specific and influenced by leptin. Clin Endocrinol (Oxf), 74(2), 197-205. Abstract. Author URL. Dickens AP, Lang IA, Langa KM, Kos K, Llewellyn DJ (2011). Vitamin D, cognitive dysfunction and dementia in older adults. CNS Drugs, 25(8), 629-639. Abstract. Author URL. Article has an altmetric score of 7 Kos K, Wong SP, Huda MS, Cakir M, Jernas M, Carlsson L, Kerrigan D, Wilding JP, Pinkney JH (2010). In humans the adiponectin receptor R2 is expressed predominantly in adipose tissue and linked to the adipose tissue expression of MMIF-1. Diabetes Obes Metab, 12(4), 360-363. Abstract. Author URL. Kos K, Wilding JP (2010). SPARC: a key player in the pathologies associated with obesity and diabetes. Nat Rev Endocrinol, 6(4), 225-235. Abstract. Author URL. Mracek T, Ding Q, Tzanavari T, Kos K, Pinkney J, Wilding J, Trayhurn P, Bing C (2010). The adipokine zinc-alpha2-glycoprotein (ZAG) is downregulated with fat mass expansion in obesity. Clin Endocrinol (Oxf), 72(3), 334-341. Abstract. Author URL. Kos K, Wilding JP (2009). Adipokines: emerging therapeutic targets. Curr Opin Investig Drugs, 10(10), 1061-1068. Abstract. Author URL.