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个人简介

Chris Hyde was recruited to Exeter in 2009. He is a School lead for research on test evaluation including systematic reviews, economic models and primary research. He leads the Exeter Test Group and is the diagnostics theme lead for PenCLAHRC. He is part of the Peninsula Technology Assessment Group (PenTAG). He directed the team delivering health technology assessments for national policy-making bodies, particularly NICE, from 2009 until 2015 and continues to support it by being the lead on HTAs of tests and through membership of its steering group. He is a long standing member of NICE's Diagnositc Advisory Committee and recently joined the National Screening Committee. Chris qualified in medicine in 1986 and worked in general medicine until 1990. He then undertook specialist training in Public Health, completing this in 1996. In 1994 he did a placement at the UK Cochrane Centre as part of his specialist training and became interested in using research to inform decisions about health. In 1996 he set up and directed a unit based in the University of Birmingham to support commissioners of health care use research (ARIF) which continued until 2012. He became progressively more active in doing research as well as disseminating it and became Director of the West Midlands Health Technology Assessment Collaboration (WMHTAC) in 2007. He was also closely involved in setting up the NHS Blood & Transplant Systematic Reviews Initiative and has contributed to the work of the Cochrane Collaboration since its inception. Throughout his career Chris has been variously intrigued and frustrated by research on tests and their interpretation. He has done many systematic reviews and health economic models on a wide variety tests including near patient tests in primary care, novel methods of processing cervical smears, hysteroscopy, tests for predicting preeclampsia and preterm birth, PET/CT scanning for breast cancer and OSNA for sentinel lymph node biopsy in breast cancer. A recurring theme is that test evaluations are often not fit for purpose and provide only indirect evidence about whether a new test will benefit patients and society if introduced. Helping to improve this situation is the main purpose of Chris’s research at UEMS.

研究领域

Test evaluation is Chris’s main area of interest. He works closely with a number of clinical groups in UEMS and beyond to support evaluation. Pre-eminent among these is Prof Hattersley’s team. Chris, Jaime Peters and Rob Anderson are using economic modelling alongside a series of clinical studies to assess the effectiveness and cost-effectiveness of systematically testing for genetically determined diabetes (the UNITED project). A similar approach is being used to evaluate the effectiveness and cost-effectiveness of school entry hearing screening working with Prof Fortnum’s audiology group in Nottingham. Traditional economic modelling and systematic reviewing, independent of new data collection, remains the mainstay of our evaluative approach. I am closely involved with the Cochrane Collaboration Dementia and Cognitive Improvement Group’s work to systematically review accuracy studies on the wide range of tests which have been suggested for dementia. Working with Harriet Hunt I am contributing to an NIHR programme grant on coagulopathy in trauma through systematic reviews on the value of TEG and ROTEM. Our Technology Appraisal Group have recently completed health technology assessments on OSNA for sentinel lymph node biopsy in breast cancer and testing strategies for Lynch syndrome. Chris is committed to methodological development. He was closely involved with the development of a new evaluation framework for tests by Lavinia Ferrante di Ruffano in Birmingham. Chris and colleagues at UEMS are currently considering whether our existing classifications and descriptions of different research designs for test evaluation are adequate. He contributed to NICE’s methods guidance on the appraisal of tests. Chris and colleagues are also working directly to translate research into practice through the Peninsula CLAHRC. We have been fostering skill development in systematic reviews of test accuracy using CT coronary angiography and high sensitivity troponin in acute MI as exemplars. Chris helps direct a team exploring the reasons for variation of thyroid function test ordering in primary care as a prelude to an evidence based approach to reducing variation in test use (the UNTEST project). Led by Chris, Zhivko Zhelev undertook an innovative application of cognitive interviewing to the investigation of what readers understand when reading the newly introduced Cochrane reviews of test accuracy. Chris remains committed to policy making. He leads the Technology Appraisal Report team providing 4 to 6 health technology assessments or appraisals of manufacturer submissions to NICE annually. He also sits on NICE’s Diagnostics Appraisal Committee. Chris describes his research into the impact of tests on patients as part of the Exeter Test Group and PenTAG (the Peninsula Technology Assesment Group), in the video below.

近期论文

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Hardwick RJL, Heaton J, Griffiths G, Vaidya B, Child S, Fleming S, Hamilton WT, Tomlinson J, Zhelev Z, Patterson A, et al (In Press). Exploring reasons for variation in ordering thyroid function tests in primary care: a qualitative study. Quality in Primary Care, 22, 256-261. Abstract. Full text. Jones AG, mcdonald TJ, Shields BM, Hill AV, Hyde CJ, Knight BA, Hattersley AT (In Press). Markers of beta cell failure predict poor glycemic response to GLP-1 receptor agonist therapy in type 2 diabetes. Diabetes Care Full text. Crathorne L, Huxley N, Haasova M, Snowsill T, Jones-Hughes T, Hoyle M, Briscoe S, Coelho H, Long H, Medina-Lara A, et al (In Press). The effectiveness and cost-effectiveness of erythropoiesis-stimulating agents (epoetin and darbepoetin) for treating cancer-treatment induced anaemia (including review of TA142): a systematic review and economic model. Health Technology Assessment Abstract. Full text. Grigore B, Peters J, Hyde C, Stein K (2016). A comparison of two methods for expert elicitation in health technology assessments. BMC Med Res Methodol, 16 Abstract. Author URL. Article has an altmetric score of 8 Fortnum H, Ukoumunne OC, Hyde C, Taylor RS, Ozolins M, Errington S, Zhelev Z, Pritchard C, Benton C, Moody J, et al (2016). A programme of studies including assessment of diagnostic accuracy of school hearing screening tests and a cost-effectiveness model of school entry hearing screening programmes. Health Technol Assess, 20(36), 1-178. Abstract. Author URL. Full text. Article has an altmetric score of 13 Jennison C, Jobling A, Pearson E, Hattersley A, Gray A, Hyde C (2016). Assessing the benefits of a stratified treatment strategy which improves average HbA1c in a proportion of patients with Type 2 diabetes: a MASTERMIND study. DIABETIC MEDICINE, 33, 23-23. Author URL. Iyengar SS, Morgan-Hughes G, Ukoumunne O, Clayton B, Davies EJ, Nikolaou V, Hyde CJ, Shore AC, Roobottom CA (2016). Diagnostic accuracy of high-definition CT coronary angiography in high-risk patients. Clin Radiol, 71(2), 151-158. Abstract. Author URL. Article has an altmetric score of 1 Zhelev Z, Abbott R, Rogers M, Fleming S, Patterson A, Hamilton WT, Heaton J, Thompson Coon J, Vaidya B, Hyde C, et al (2016). Effectiveness of interventions to reduce ordering of thyroid function tests: a systematic review. BMJ Open, 6(6). Abstract. Author URL. Article has an altmetric score of 4 Haasova M, Snowsill T, Jones-Hughes T, Crathorne L, Cooper C, Varley-Campbell J, Mujica-Mota R, Coelho H, Huxley N, Lowe J, et al (2016). Immunosuppressive therapy for kidney transplantation in children and adolescents: systematic review and economic evaluation. Health Technol Assess, 20(61), 1-324. Abstract. Author URL. Full text. Article has an altmetric score of 2 Shepherd M, Shields B, Hammersley S, Hudson M, McDonald TJ, Colclough K, Oram RA, Knight B, Hyde C, Cox J, et al (2016). Systematic Population Screening, Using Biomarkers and Genetic Testing, Identifies 2.5% of the U.K. Pediatric Diabetes Population with Monogenic Diabetes. Diabetes Care Abstract. Author URL. Full text. Article has an altmetric score of 4 Bond M, Garside R, Hyde C (2015). A crisis of visibility: the psychological consequences of false-positive screening mammograms, an interview study. British Journal of Health Psychology, 20(4), 792-806. Abstract. Article has an altmetric score of 7 Snowsill T, Huxley N, Hoyle M, Jones-Hughes T, Coelho H, Cooper C, Frayling I, Hyde C (2015). A model-based assessment of the cost-utility of strategies to identify Lynch syndrome in early-onset colorectal cancer patients. BMC Cancer, 15 Abstract. Author URL. Full text. Article has an altmetric score of 8 Huxley N, Jones-Hughes T, Coelho H, Snowsill T, Cooper C, Meng Y, Hyde C, Mújica-Mota R (2015). A systematic review and economic evaluation of intraoperative tests [RD-100i one-step nucleic acid amplification (OSNA) system and Metasin test] for detecting sentinel lymph node metastases in breast cancer. Health Technol Assess, 19(2), v-215. Abstract. Author URL. Full text. Marshall MJ, Smart NJ, Hyde C, Winyard PG, Shaw AM, Daniels IR (2015). Biomarkers for diagnosis of acute appendicitis in adults. COCHRANE DATABASE OF SYSTEMATIC REVIEWS(3). Author URL. Shields BM, Peters JL, Cooper C, Lowe J, Knight BA, Powell RJ, Jones A, Hyde CJ, Hattersley AT (2015). Can clinical features be used to differentiate type 1 from type 2 diabetes? a systematic review of the literature. BMJ Open, 5(11). Abstract. Author URL. Full text. Article has an altmetric score of 6 Castro R, Perazzo H, Grinsztejn B, Veloso VG, Hyde C (2015). Chronic Hepatitis C: an Overview of Evidence on Epidemiology and Management from a Brazilian Perspective. Int J Hepatol, 2015 Abstract. Author URL. Zhelev Z, Hyde C, Youngman E, Rogers M, Fleming S, Slade T, Coelho H, Jones-Hughes T, Nikolaou V (2015). Diagnostic accuracy of single baseline measurement of Elecsys Troponin T high-sensitive assay for diagnosis of acute myocardial infarction in emergency department: systematic review and meta-analysis. BMJ, 350 Abstract. Author URL. Full text. McCleery J, Morgan S, Bradley KM, Noel-Storr AH, Ansorge O, Hyde C (2015). Dopamine transporter imaging for the diagnosis of dementia with Lewy bodies. COCHRANE DATABASE OF SYSTEMATIC REVIEWS(1). Author URL. Article has an altmetric score of 6 Smailagic N, Vacante M, Hyde C, Martin S, Ukoumunne O, Sachpekidis C (2015). F-18-FDG PET for the early diagnosis of Alzheimer's disease dementia and other dementias in people with mild cognitive impairment (MCI). COCHRANE DATABASE OF SYSTEMATIC REVIEWS(1). Author URL. Article has an altmetric score of 2 Perazzo H, Veloso VG, Grinsztejn B, Hyde C, Castro R (2015). Factors That Could Impact on Liver Fibrosis Staging by Transient Elastography. Int J Hepatol, 2015 Abstract. Author URL. Full text.

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