Hamilton, Willie - University of Exeter

个人简介

Willie is a professor of primary care diagnostics at the university. Within this, his main topic area is cancer diagnosis, though he also researches chronic fatigue and other relevant primary care topics. In cancer, Willie‘s main expertise is in identifying and quantifying the risk of cancer in patients presenting to their general practitioner with a particular symptom. He created the CAPER research unit within the University of Bristol, initially funded by the NHS research practice scheme, but now moved to the University of Exeter, and largely funded by a NIHR programme grant, DISCOVERY, and through the Policy Research Unit for Cancer Awareness, Screening and Early Diagnosis. Willie manages and provides leadership to the five current research staff, and three PhD students, with the total varying between three and six over recent years. He is also the clinical lead in the 2012-5 update of the NICE referral guidelines for suspected cancer.

研究领域

Willie's main research field is early diagnosis of cancer in primary care. He has produced dozens of cancer diagnostic peer-reviewed publications, plus an award winning textbook. Willie lead the Early Diagnosis Subgroup within the NCRI’s primary care clinical studies group until recently. He also holds a £2m NIHR programme grant as PI entitled ‘optimising diagnosis of symptomatic cancer’ (2010-2015) and is a founder co-applicant to the DH’s Policy Research Unit on Cancer screening, awareness and early diagnosis, funded by a £5m grant from the DH. 21 of Willie's 31 project grants are based on aspects of cancer diagnosis. Willie has led the UK cancer diagnosis agenda for several years, and has produced charts on cancer risk that are now being used for 13 cancers in UK GP surgeries to assess risk. This work was presented in a symposium at the 2013 NCRI annual conference, which Willie chaired, and has attracted considerable media interest. The system is now being tested as software for GPs clinical computers which prompts when the risk of cancer is above 2%. The study is being funded by DH, CRUK and Macmillan.

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Ukoumunne OC, Moore H, Nixon C, Tariq A, Hamilton W, Hoare Z, Kershenbaum A, Neal RD, Usher-Smith J, Walter FM, et al (In Press). Evaluating a computer aid for assessing stomach symptoms (ECASS): study protocol for a multi-site phase II exploratory cluster randomised controlled trial. Trials Abstract. Full text. Hardwick RJL, Heaton J, Griffiths G, Vaidya B, Child S, Fleming S, Hamilton WT, Tomlinson J, Zhelev Z, Patterson A, et al (In Press). Exploring reasons for variation in ordering thyroid function tests in primary care: a qualitative study. Quality in Primary Care, 22, 256-261. Abstract. Full text. walter F, Emery JD, Mendonce S, Hall N, Morris HC, Mills K, Dobson C, Bankhead C, Johnson M, Abel GA, et al (In Press). Symptoms and patient factors associated with longer time to diagnosis for colorectal cancer: results from a prospective cohort study. British Journal of Cancer Hamilton WT, Hollinghurst S, Banks J, Bigwood L, Walter F, Peters TJ (In Press). Using willingness-to-pay to establish patient preferences for cancer testing in primary care. BMC Medical Informatics and Decision Making Full text. Watson J, de Salis I, Hamilton W, Salisbury C (2016). 'I'm fishing really'--inflammatory marker testing in primary care: a qualitative study. Br J Gen Pract, 66(644), e200-e206. Abstract. Author URL. Full text. Article has an altmetric score of 5 Merriel SW, Carroll R, Hamilton F, Hamilton W (2016). Association between unexplained hypoalbuminaemia and new cancer diagnoses in UK primary care patients. Fam Pract, 33(5), 449-452. Abstract. Author URL. Article has an altmetric score of 4 Zhelev Z, Abbott R, Rogers M, Fleming S, Patterson A, Hamilton WT, Heaton J, Thompson Coon J, Vaidya B, Hyde C, et al (2016). Effectiveness of interventions to reduce ordering of thyroid function tests: a systematic review. BMJ Open, 6(6). Abstract. Author URL. Article has an altmetric score of 4 Landy R, Castanon A, Hamilton W, Lim AW, Dudding N, Hollingworth A, Sasieni PD (2016). Evaluating cytology for the detection of invasive cervical cancer. Cytopathology, 27(3), 201-209. Abstract. Author URL. Full text. Hamilton W, Walter FM, Rubin G, Neal RD (2016). Improving early diagnosis of symptomatic cancer. Nature Reviews Clinical Oncology Abstract. Article has an altmetric score of 18 Nicholson BD, Mant D, Neal RD, Hart N, Hamilton W, Shinkins B, Rubin G, Rose PW (2016). International variation in adherence to referral guidelines for suspected cancer: a secondary analysis of survey data. Br J Gen Pract, 66(643), e106-e113. Abstract. Author URL. Full text. Article has an altmetric score of 21 Price SJ, Stapley SA, Shephard E, Barraclough K, Hamilton WT (2016). Is omission of free text records a possible source of data loss and bias in Clinical Practice Research Datalink studies? a case-control study. BMJ Open, 6(5). Abstract. Author URL. Full text. Article has an altmetric score of 3 Lim AW, Hamilton W, Hollingworth A, Stapley S, Sasieni P (2016). Performance characteristics of visualising the cervix in symptomatic young females: a review of primary care records in females with and without cervical cancer. Br J Gen Pract, 66(644), e189-e192. Abstract. Author URL. Full text. Article has an altmetric score of 4 Schmidt-Hansen M, Berendse S, Hamilton W (2016). Symptoms of Pancreatic Cancer in Primary Care: a Systematic Review. Pancreas, 45(6), 814-818. Abstract. Author URL. Full text. Article has an altmetric score of 5 Shephard EA, Neal RD, Rose PW, Walter FM, Hamilton W (2016). Symptoms of adult chronic and acute leukaemia before diagnosis: large primary care case-control studies using electronic records. Br J Gen Pract, 66(644), e182-e188. Abstract. Author URL. Full text. Article has an altmetric score of 20 Martins T, Hamilton W (2016). The influence of ethnicity on diagnosis of cancer. Fam Pract, 33(4), 325-326. Author URL. Article has an altmetric score of 2 Robson JC, Kiran A, Maskell J, Hutchings A, Arden N, Dasgupta B, Hamilton W, Emin A, Culliford D, Luqmani R, et al (2016). Which Patients with Giant Cell Arteritis Will Develop Cardiovascular or Cerebrovascular Disease? a Clinical Practice Research Datalink Study. J Rheumatol, 43(6), 1085-1092. Abstract. Author URL. Article has an altmetric score of 2 Din NU, Ukoumunne OC, Rubin G, Hamilton W, Carter B, Stapley S, Neal RD (2015). Age and Gender Variations in Cancer Diagnostic Intervals in 15 Cancers: Analysis of Data from the UK Clinical Practice Research Datalink. PLoS One, 10(5). Abstract. Author URL. Full text. Article has an altmetric score of 22 Hamilton W, Hajioff S, Graham J, Schmidt-Hansen M (2015). Authors' reply to Steele and colleagues. BMJ, 351 Author URL. Full text. Robson J, Kiran A, Hutchings A, Maskell J, Arden NK, Hamilton W, Dasgupta B, Luqmani R (2015). Cardiovascular and Cerebrovascular Disease and Social Deprivation in Patients with Giant Cell Arteritis. ARTHRITIS & RHEUMATOLOGY, 67 Author URL.