Ellacott, Kate - University of Exeter

个人简介

BSc. Pharmacology (1999) – University of Edinburgh Ph.D. Neuroscience (2002) – University of Manchester Pg.Cert. Academic Practice (2016) - University of Exeter Assocaite Fellow Higher Education Academy (2015) - University of Exeter Career After completing a PhD at the University of Manchester under the supervision of Profs. Nancy Rothwell and Simon Luckman she was awarded a Wellcome Trust post-doctoral travelling fellowship to study with Dr Roger Cone at the Vollum Institute in Portland, Oregon, USA. Kate remained in Oregon until 2008 when she joined the faculty Vanderbilt University Medical Center in Nashville, Tennessee and started an independent research programme examining the effect of obesity on central nervous system function. While at Vanderbilt, Kate also served as Associate Director of the Metabolic Pathophysiology Core of the Vanderbilt Mouse Metabolic Phenotyping Center. Kate joined the University of Exeter Medical School in 2014 as a Senior Lecturer (Education & Research).

研究领域

Kate's broad research interest is understanding how the brain controls food intake and body weight. In particular her research is focused on how different cell types in the brain (neurons, microglia, astrocytes and endothelial cells) coordinate and interact to regulate these processes. Her lab also studies how the normal function of the brain changes in response to alterations in body weight including obesity (excess body weight) and anorexia/cachexia (insufficient body weight), and how these changes in the brain contribute to the development of commonly associated diseases like diabetes. Obesity, a major public health issue in the U.K. that affects greater than 25% of the adult population. It is estimated to directly cost the National Health Service (NHS) £4.2billion each year and can affect all aspects of a person’s life. Currently there are limited treatment options available. The long term goal of Kate's research is to impact human health by improving our knowledge of how the brain controls food intake and body weight, which will help in the development of new therapies obesity and anorexia/cachexia.

近期论文

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Buckman LB, Thompson MM, Lippert RN, Blackwell TS, Yull FE, Ellacott KL (2015). Evidence for a novel functional role of astrocytes in the acute homeostatic response to high-fat diet intake in mice. Mol Metab, 4(1), 58-63. Abstract. Author URL. Full text. Article has an altmetric score of 10 Lippert RN, Ellacott KL, Cone RD (2014). Gender-specific roles for the melanocortin-3 receptor in the regulation of the mesolimbic dopamine system in mice. Endocrinology, 155(5), 1718-1727. Abstract. Author URL. Buckman LB, Hasty AH, Flaherty DK, Buckman CT, Thompson MM, Matlock BK, Weller K, Ellacott KL (2014). Obesity induced by a high-fat diet is associated with increased immune cell entry into the central nervous system. Brain Behav Immun, 35, 33-42. Abstract. Author URL. Article has an altmetric score of 12 Buckman LB, Anderson-Baucum EK, Hasty AH, Ellacott KLJ (2014). Regulation of S100B in white adipose tissue by obesity in mice. Adipocyte, 3(3), 215-220. Abstract. Author URL. Article has an altmetric score of 1 Buckman LB, Ellacott KL (2014). The contribution of hypothalamic macroglia to the regulation of energy homeostasis. Front Syst Neurosci, 8 Abstract. Author URL. Full text. Article has an altmetric score of 1 Pendergast JS, Branecky KL, Yang W, Ellacott KL, Niswender KD, Yamazaki S (2013). High-fat diet acutely affects circadian organisation and eating behavior. Eur J Neurosci, 37(8), 1350-1356. Abstract. Author URL. Article has an altmetric score of 5 Alcendor DJ, Block FE, Cliffel DE, Daniels JS, Ellacott KL, Goodwin CR, Hofmeister LH, Li D, Markov DA, May JC, et al (2013). Neurovascular unit on a chip: implications for translational applications. Stem Cell Res Ther, 4 Suppl 1 Abstract. Author URL. Article has an altmetric score of 9 Buckman LB, Thompson MM, Moreno HN, Ellacott KL (2013). Regional astrogliosis in the mouse hypothalamus in response to obesity. J Comp Neurol, 521(6), 1322-1333. Abstract. Author URL. Thompson MM, Manning HC, Ellacott KL (2013). Translocator protein 18 kDa (TSPO) is regulated in white and brown adipose tissue by obesity. PLoS One, 8(11). Abstract. Author URL. Article has an altmetric score of 1 Renquist BJ, Murphy JG, Larson EA, Olsen D, Klein RF, Ellacott KL, Cone RD (2012). Melanocortin-3 receptor regulates the normal fasting response. Proc Natl Acad Sci U S A, 109(23), E1489-E1498. Abstract. Author URL. Article has an altmetric score of 8 Hatoum IJ, Stylopoulos N, Vanhoose AM, Boyd KL, Yin DP, Ellacott KL, Ma LL, Blaszczyk K, Keogh JM, Cone RD, et al (2012). Melanocortin-4 receptor signaling is required for weight loss after gastric bypass surgery. J Clin Endocrinol Metab, 97(6), E1023-E1031. Abstract. Author URL. Article has an altmetric score of 7 Orr JS, Puglisi MJ, Ellacott KL, Lumeng CN, Wasserman DH, Hasty AH (2012). Toll-like receptor 4 deficiency promotes the alternative activation of adipose tissue macrophages. Diabetes, 61(11), 2718-2727. Abstract. Author URL. Article has an altmetric score of 3 Srisai D, Gillum MP, Panaro BL, Zhang XM, Kotchabhakdi N, Shulman GI, Ellacott KL, Cone RD (2011). Characterization of the hyperphagic response to dietary fat in the MC4R knockout mouse. Endocrinology, 152(3), 890-902. Abstract. Author URL. Article has an altmetric score of 6 Renquist BJ, Lippert RN, Sebag JA, Ellacott KL, Cone RD (2011). Physiological roles of the melanocortin MC₃ receptor. Eur J Pharmacol, 660(1), 13-20. Abstract. Author URL. Ellacott KL, Morton GJ, Woods SC, Tso P, Schwartz MW (2010). Assessment of feeding behavior in laboratory mice. Cell Metab, 12(1), 10-17. Abstract. Author URL. Kennedy AJ, Ellacott KL, King VL, Hasty AH (2010). Mouse models of the metabolic syndrome. Dis Model Mech, 3(3-4), 156-166. Abstract. Author URL. Ellacott KL, Murphy JG, Marks DL, Cone RD (2007). Obesity-induced inflammation in white adipose tissue is attenuated by loss of melanocortin-3 receptor signaling. Endocrinology, 148(12), 6186-6194. Abstract. Author URL. Article has an altmetric score of 1 Voss-Andreae A, Murphy JG, Ellacott KL, Stuart RC, Nillni EA, Cone RD, Fan W (2007). Role of the central melanocortin circuitry in adaptive thermogenesis of brown adipose tissue. Endocrinology, 148(4), 1550-1560. Abstract. Author URL. Article has an altmetric score of 1 Ellacott KL, Halatchev IG, Cone RD (2006). Characterization of leptin-responsive neurons in the caudal brainstem. Endocrinology, 147(7), 3190-3195. Abstract. Author URL. Ellacott KL, Halatchev IG, Cone RD (2006). Interactions between gut peptides and the central melanocortin system in the regulation of energy homeostasis. Peptides, 27(2), 340-349. Abstract. Author URL.