Eggleton, Paul - University of Exeter

个人简介

1979–1983: Plymouth University. Plymouth, Devon, England. (A) Higher National Diploma in Applied Biology. (B) B.Sc. Hons. Biological Sciences – Upper second class (2.i). 1985–1987: University College London -Royal Free Hospital School of Medicine. M.Phil. Medical Microbiology Thesis title: Rapid techniques for the measurement of non-–specific host responses to bacterial infection. 1987–1991: University College London - Royal College of Surgeons of England & Royal Free Hospital School of Medicine. Ph.D. Biochemistry Thesis title: Studies of subpopulation heterogeneity in the circulating neutrophil pool. Career University of Oxford, UK - 1994-2002 June 1994–August 2002. MRC Immunochemistry Unit, Dept. Biochemistry. South Parks Road. Oxford OX1 3QU. 1994-2002 Position: Research Fellow. (Personal fellowships funded by MRC and ARC) Laboratory Host: Professor KBM Reid FRS. Project A: Structural and functional characterisation of calreticulin in human leucocytes in relation to autoimmune disease Project B: Role of lung surfactant proteins in innate immunity. 1996-2002. Position: Senior Department Teaching Associate. Responsible for designing and managing the first taught D.Phil. course in Biochemistry at the University of Oxford. 1999-2002. Position: University Research Lecturer and Member of congregation, University of Oxford. Boston University, USA - 1992-1994. March 1992-May 1994 Department of Pathology, School of Medicine. Position; Research Fellow. Laboratory host: Professor Alfred. I. Tauber. Project: Characterisation of C1q receptors on human neutrophils. Royal College of Surgeons of England, London, UK - .1989-1992 1989–92. Department of Biochemistry, Hunterian Institute, Position: Research Associate. (ARC – funded). Laboratory host: Professor Neville Crawford. Project: Subpopulation heterogeneity in the circulating neutrophil pool: implications for functional expression in the inflammatory response. Royal Free Hospital School of Medicine, London UK - 1983-87. 1983–87. Department of Medical Microbiology. Position; Research Assistant. (NETRHA - funded) Laboratory host: Dr. G.W. Smith. Project: Rapid detection assays of host response to bacterial disease.

研究领域

Dr Eggleton‘s research interest focuses on the understanding of innate and adaptive immunity in the pathology of autoimmune disease (systemic lupus erythematosus, rheumatoid arthritis and multiple sclerosis) and more recently, cancer, with a special interest in the role of endoplasmic reticulum chaperone proteins (calreticulin/calnexin). Dr Eggleton has made important contributions to medical research through his research in characterizing the immune function of the collectin molecules (SP-A and SP-D) and complement proteins (e.g. C1q). He contributed to the discovery of the lectin pathway of complement activation, which has had far reaching implications as to how human immunity deals with microbial infections. He is also known for his work shown that endoplasmic reticulum (ER) chaperones – e.g. calreticulin have extracellular immune modulating functions. This has led to a whole new avenue of research into the role of calreticulin in the cell death of cancers and the ability of parasites to avoid immune detection. His recent work has contributed to the discovery of a subset of CD20+, T-lymphocytes that appear to have a role in many human pathological processes. In addition, his work on post-translational modification of host proteins by oxidative stress and epigenetic/microbial influences has provided insight as to how autoantibodies are generated in autoimmune disease as well explaining how such autoantibodies are implicated in both pathology and as early diagnostic markers of disease of both systemic lupus erythematosus and rheumatoid arthritis.

近期论文

查看导师新发文章（温馨提示：请注意重名现象，建议点开原文通过作者单位确认）

Tarr1 JM, Young PJ, Morse R, Shaw DJ, Haigh R, Petrov PG, Johnson SJ, Winyard PG, Eggleton P (In Press). A mechanism of release of calreticulin from cells during apoptosis. J Molecular Biology Abstract. Full text. Gold L, Williams D, Groenendyk J, Michalak M, Eggleton P (In Press). Unfolding the complexities of ER chaperones in health and disease: Report on the 11th International Calreticulin Workshop. Cell Stress and Chaperones Abstract. Full text. Article has an altmetric score of 1 Hutchinson D, Murphy D, Clarke A, Eggleton P (2016). Are Rheumatoid Factor, Anti-Citrullinated Protein Antibodies, and Anti-Carbamylated Protein Antibodies Linked by Posttranslational Modification of IgG? Comment on the Article by Koppejan et al. Arthritis Rheumatol, 68(11), 2825-2826. Author URL. Full text. Eggleton P, Bremer E, Dudek E, Michalak M (2016). Calreticulin, a therapeutic target?. Expert Opin Ther Targets, 20(9), 1137-1147. Abstract. Author URL. Article has an altmetric score of 1 Quirke A-M, Perry E, Cartwright A, Kelly C, De Soyza A, Eggleton P, Hutchinson D, Venables PJ (2015). Bronchiectasis: a model for chronic bacterial infection inducing autoimmunity in rheumatoid arthritis. Arthritis and Rheumatology, 67(9), 2335-2342. Abstract. Full text. de Bruyn M, Wiersma V, Samplonius DF, Klip HG, Helfrich W, Nijman HW, Eggleton P, Bremer E (2015). CD20+ T cells have a predominantly Tc1 Effector Memory phenotype and are expanded in the ascitis of patients with ovarian cancer. Oncoimmunology, 4 Abstract. Full text. Article has an altmetric score of 2 Eggleton P, Michalak M, Bremer E (2015). Editorial: Endoplasmic Reticulum and its Role in Tumor Immunity. Front Oncol, 5 Author URL. Full text. Article has an altmetric score of 2 Perry E, Eggleton P, De Soyza A, Hutchinson D, Kelly C (2015). Increased disease activity, severity and autoantibody positivity in rheumatoid arthritis patients with co-existent bronchiectasis. International Journal of Rheumatic Diseases, 18 Abstract. Full text. Wiersma VR, Michalak M, Abdullah TM, Bremer E, Eggleton P (2015). Mechanisms of translocation of ER chaperones to the cell surface and immunomodulatory roles in cancer and autoimmunity. Frontiers in Oncology, 5(7). Abstract. Full text. Article has an altmetric score of 1 Eggleton P, Bishop A, Smerdon G (2015). Safety and efficacy of hyperbaric oxygen therapy in chronic wound management: current evidence. Chronic Wound Care Management and Research, 2 Abstract. Full text. Wiersma VR, de Bruyn M, Wei Y, van Ginkel RJ, Hirashima M, Niki T, Nishi N, Zhou J, Pouwels SD, Samplonius DF, et al (2015). The epithelial polarity regulator galectin-9 induces fatal frustrated autophagy in KRAS mutant colon carcinoma that depends on elevated basal autophagic flux. Autophagy, 11, 1373-1388. Abstract. Full text. Article has an altmetric score of 1 de Bruyn M, Wiersma VR, Helfrich W, Eggleton P, Bremer E (2015). The ever-expanding immunomodulatory role of calreticulin in cancer immunity. Frontiers in Oncology, 5 Abstract. Full text. Article has an altmetric score of 3 Wiersma VR, He Y, Samplonius DF, van Ginkel RJ, Gerssen J, Eggleton P, Zhou J, Bremer E, Helfrich W (2014). A CD47-blocking TRAIL fusion protein with dual pro-phagocytic and pro-apoptotic anticancer activity. British Journal of Haematology, 164(2), 304-307. Article has an altmetric score of 5 Eggleton P, Ukoumunne OC, Cottrell I, Khan A, Maqsood S, Thornes J, Perry E, Isenberg D (2014). Autoantibodies against C1q as a diagnostic measure of lupus nephritis:systematic review and meta-analysis. Journal of clinical and cellular Immunology, 5(2). Abstract. Full text. Quirke A-M, Perry E, Cartwright A, Kelly C, De Sozya A, Eggleton P, Hutchinson D, Venables P (2014). Bronchiectasis: a Model for Chronic Bacterial Infection Inducing Autoimmunity in Rheumatoid Arthritis. ARTHRITIS & RHEUMATOLOGY, 66, S185-S185. Author URL. Holley JE, Bremer E, Kendall AC, De Bruyn M, Helfrich W, Tarr JM, Newcombe J, Gutowski NJ, Eggleton P (2014). CD20+inflammatory T-cells are present in blood and brain of multiple sclerosis patients and can be selectively targeted for apoptotic elimination. Multiple Sclerosis and Related Disorders, 3(5), 650-658. Abstract. Article has an altmetric score of 11 Eggleton P, Bremer E (2014). Direct and indirect rituximab-induced T cell depletion: comment on the article by Mélet et Al. Arthritis Rheumatol, 66(4). Author URL. Eggleton P, Bremer E (2014). Direct and indirect rituximab-induced T-cell depletion. Arthritis and Rheumatism Eggleton P, Bremer E (2014). Direct and indirect rituximab-induced T-cell depletion: Comment on the article by Mélet et al. Arthritis Rheum Author URL. Holley JE, Bremer E, Kendall AC, de Bruyn M, Helfrich W, Tarr JM, Newcombe J, Gutowski NJ, Eggleton P (2014). Identification of CD20+ Th17 cells in the blood and brain of multiple sclerosis patients and possible elimination by novel anti-CD20 biological therapeutics. Multiple Sclerosis and related disorders, 3(5). Abstract.