Dempster, Emma - University of Exeter

个人简介

I graduated with an honors degree in Genetics from Cardiff University in 1998 and subsequently spent two years in industry. In 2000 I was awarded an MRC predoctoral studentship to undertake a PhD at the Institute of Psychiatry, King’s College London (KCL) where I focused on identifying genetic variation associated with schizophrenia. Career After completing my PhD I moved to Canada where I was awarded a University of Toronto Postdoctoral Fellowship to examine functional variation in genes related to stress in the aetiology of depression. Family circumstances brought me back to the UK where I joined Dr Mill’s psychiatric epigenetics group in KCL and then subsequently relocated with Professor Mill to the Univeristy of Exeter in 2012.

研究领域

My main current research focus is on epigenetic changes observed in twins discordant for disease, I am currently collating one of the largest cohorts of schizophrenia discordant twins in epigenetic research. My other research interests include the effects of CNVs on DNA methlyation patterns, how THC exposure influences DNA methylation and profiling other epigenetic modifications.

近期论文

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Marzi SJ, Meaburn EL, Dempster EL, Lunnon K, Paya-Cano JL, Smith RG, Volta M, Troakes C, Schalkwyk LC, Mill J, et al (2016). Tissue-specific patterns of allelically-skewed DNA methylation. Epigenetics, 11(1), 24-35. Abstract. Author URL. Full text. Article has an altmetric score of 18 Lunnon K, Hannon E, Smith RG, Dempster E, Wong C, Burrage J, Troakes C, Al-Sarraj S, Kepa A, Schalkwyk L, et al (2016). Variation in 5-hydroxymethylcytosine across human cortex and cerebellum. Genome Biol, 17 Abstract. Author URL. Full text. Article has an altmetric score of 12 Unternaehrer E, Meyer AH, Burkhardt SC, Dempster E, Staehli S, Theill N, Lieb R, Meinlschmidt G (2015). Childhood maternal care is associated with DNA methylation of the genes for brain-derived neurotrophic factor (BDNF) and oxytocin receptor (OXTR) in peripheral blood cells in adult men and women. Stress, 18(4), 451-461. Abstract. Author URL. Article has an altmetric score of 1 Wong CC, Parsons MJ, Lester KJ, Burrage J, Eley TC, Mill J, Dempster EL, Gregory AM (2015). Epigenome-Wide DNA Methylation Analysis of Monozygotic Twins Discordant for Diurnal Preference. Twin Res Hum Genet, 18(6), 662-669. Abstract. Author URL. Full text. Article has an altmetric score of 12 Fisher HL, Murphy TM, Arseneault L, Caspi A, Moffitt TE, Viana J, Hannon E, Pidsley R, Burrage J, Dempster EL, et al (2015). Methylomic analysis of monozygotic twins discordant for childhood psychotic symptoms. Epigenetics, 10(11), 1014-1023. Abstract. Author URL. Full text. Article has an altmetric score of 9 Fisher H, Murphy T, Arseneault L, Burrage J, Dempster E, Caspi A, Moffitt T, Mill J (2014). Genome-wide DNA methylation profiling in monozygotic twins discordant for psychotic symptoms at age 12. EARLY INTERVENTION IN PSYCHIATRY, 8, 57-57. Author URL. Dempster EL, Wong CCY, Lester KJ, Burrage J, Gregory AM, Mill J, Eley TC (2014). Genome-wide methylomic analysis of monozygotic twins discordant for adolescent depression. Biological Psychiatry, 76(12), 977-983. Abstract. Article has an altmetric score of 3 Dempster EL, Wong CC, Lester KJ, Burrage J, Gregory AM, Mill J, Eley TC (2014). Genome-wide methylomic analysis of monozygotic twins discordant for adolescent depression. Biol Psychiatry, 76(12), 977-983. Abstract. Author URL. Full text. Article has an altmetric score of 3 Davies MN, Krause L, Bell JT, Gao F, Ward KJ, Wu H, Lu H, Liu Y, Tsai P-C, Collier DA, et al (2014). Hypermethylation in the ZBTB20 gene is associated with major depressive disorder. GENOME BIOLOGY, 15(4). Author URL. Article has an altmetric score of 48 Ilott NE, Schneider T, Mill J, Schalkwyk L, Brolese G, Bizarro L, Stolerman IP, Dempster E, Asherson P (2014). Long-term effects of gestational nicotine exposure and food-restriction on gene expression in the striatum of adolescent rats. PLoS One, 9(2). Abstract. Author URL. Full text. Article has an altmetric score of 1 Basil P, Li Q, Dempster EL, Mill J, Sham P-C, Wong CCY, McAlonan GM (2014). Prenatal maternal immune activation causes epigenetic differences in adolescent mouse brain. Translational Psychiatry, 4(9), e455-e455. Article has an altmetric score of 1 Basil P, Li Q, Dempster EL, Mill J, Sham PC, Wong CC, McAlonan GM (2014). Prenatal maternal immune activation causes epigenetic differences in adolescent mouse brain. Transl Psychiatry, 4 Abstract. Author URL. Article has an altmetric score of 10 Barros M, Dempster EL, Illott N, Chabrawi S, Maior RS, Tomaz C, Silva MA, Huston JP, Mill J, Müller CP, et al (2013). Decreased methylation of the NK3 receptor coding gene (TACR3) after cocaine-induced place preference in marmoset monkeys. Addict Biol, 18(3), 452-454. Abstract. Author URL. Dempster E, Viana J, Pidsley R, Mill J (2013). Epigenetic studies of schizophrenia: progress, predicaments, and promises for the future. Schizophr Bull, 39(1), 11-16. Abstract. Author URL. Article has an altmetric score of 3 Pjetri E, Dempster E, Collier DA, Treasure J, Kas MJ, Mill J, Campbell IC, Schmidt U (2013). Quantitative promoter DNA methylation analysis of four candidate genes in anorexia nervosa: a pilot study. J Psychiatr Res, 47(2), 280-282. Author URL. Xie W, Barr CL, Kim A, Yue F, Lee AY, Eubanks J, Dempster EL, Ren B (2012). Base-Resolution Analyses of Sequence and Parent-of-Origin Dependent DNA Methylation in the Mouse Genome. CELL, 148(4), 816-831. Author URL. Article has an altmetric score of 3 Unternaehrer E, Luers P, Mill J, Dempster E, Meyer AH, Staehli S, Lieb R, Hellhammer DH, Meinlschmidt G (2012). Dynamic changes in DNA methylation of stress-associated genes (OXTR, BDNF) after acute psychosocial stress. TRANSLATIONAL PSYCHIATRY, 2 Author URL. Article has an altmetric score of 80 Pidsley R, Dempster E, Troakes C, Al-Sarraj S, Mill J (2012). Epigenetic and genetic variation at the IGF2/H19 imprinting control region on 11p15.5 is associated with cerebellum weight. Epigenetics, 7(2), 155-163. Abstract. Author URL. Article has an altmetric score of 20 Bell JT, Tsai P-C, Yang T-P, Pidsley R, Nisbet J, Glass D, Mangino M, Zhai G, Zhang F, Valdes A, et al (2012). Epigenome-Wide Scans Identify Differentially Methylated Regions for Age and Age-Related Phenotypes in a Healthy Ageing Population. PLOS GENETICS, 8(4), 189-200. Author URL. Article has an altmetric score of 38 Mizuno K, Dempster E, Mill J, Giese KP (2012). Long-lasting regulation of hippocampal Bdnf gene transcription after contextual fear conditioning. Genes Brain Behav, 11(6), 651-659. Abstract. Author URL.