Curnow, Alison - University of Exeter

个人简介

Dr Curnow is a senior member of the University of Exeter Medical School’s academic teaching faculty and the majority of her working week is dedicated to developing and delivering the School’s medical and scientific undergraduate and postgraduate programmes. She is currently Programme Lead for our MSc in Environment & Human Health and has become an experienced educator with a wide range of teaching, assessment and curriculum development skills. She is also an accomplished biomedical scientist with nineteen years experience of conducting photobiological and oncological related research. She is known worldwide for her photodynamic therapy (PDT) research and leadership. She is currently Secretary General of the International Photodynamic Association (2009 to present) and has previously been an Editor of an international scientific journal (2001-2010).

研究领域

Experimental research projects (conducted mainly with human skin cells at the University of Exeter’s Cornwall site where the new Environment and Sustainability Institute laboratory facility has been built) include investigations of the mechanism and enhancement of PDT, the use of natural products to prevent the DNA damage caused by sunlight and determining the biological effects that compounds may have with or without the presence of ultraviolet radiation (including environmental contaminants such as arsenic, radon, polyaromatic hydrocarbons and airborne particulate matter). This photobiological research programme focuses on oxidative stress as both PDT and ultraviolet radiation can produce reactive oxygen species.

近期论文

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Curnow A, Horton SJ (In Press). An evaluation of root phytochemicals derived from Althea officinalis (Marshmallow) and Astragalus membranaceus as potential natural components of UV-protecting dermatological formulations. Oxidative Medicine and Cellular Longevity Abstract. Full text. Curnow A, MacRobert AJ, Bown SG (2015). Enhancing Protoporphyrin IX-induced Photodynamic Therapy with a Topical Iron Chelating Agent in a Normal Skin Model. Journal of Heavy Metal Toxicity and Diseases, 1(1), 1-9. Abstract. Full text. Curnow A, Pye A (2015). The importance of iron chelation and iron availability during PpIX-induced photodynamic therapy. Photonics and Lasers in Medicine, 4(1), 39-58. Abstract. Full text. Blake E, Allen J, Thorn C, Shore A, Curnow A (2013). Effect of an oxygen pressure injection (OPI) device on the oxygen saturation of patients during dermatological methyl aminolevulinate photodynamic therapy. Lasers in Medical Science, 28(3), 997-1005. Abstract. Full text. Robertson A, Allen J, Laney R, Curnow A (2013). The cellular and molecular carcinogenic effects of radon exposure: a review. Int J Mol Sci, 14(7), 14024-14063. Abstract. Author URL. Full text. Article has an altmetric score of 4 Blake E, Allen J, Curnow A (2013). The effects of protoporphyrin IX-induced photodynamic therapy with and without iron chelation on human squamous carcinoma cells cultured under normoxic, hypoxic and hyperoxic conditions. Photodiagnosis and Photodynamic Therapy, 10(4), 575-582. Abstract. Ferguson D, Smerdon GR, Eggleton P, Curnow A, Winyard PG (2012). Altering oxygen concentrations to enhance the efficacy of PpIX-based photodynamic cell killing. FREE RADICAL BIOLOGY AND MEDICINE, 53, S127-S127. Author URL. Wheeler BW, Allen J, Depledge MH, Curnow A (2012). Radon and skin cancer in southwest England: an ecologic study. Epidemiology, 23(1), 44-52. Abstract. Full text. Article has an altmetric score of 29 Blake E, Campbell S, Allen J, Mathew J, Helliwell P, Curnow A (2012). The time-dependent accumulation of protoporphyrin IX fluorescence in nodular basal cell carcinoma following application of methyl aminolevulinate with an oxygen pressure injection device. J Photochem Photobiol B, 117, 97-103. Abstract. Author URL. Full text. Blake E, Allen J, Curnow A (2011). An in vitro comparison of the effects of the iron-chelating agents, CP94 and dexrazoxane, on protoporphyrin IX accumulation for photodynamic therapy and/or fluorescence guided resection. Photochem Photobiol, 87(6), 1419-1426. Abstract. Author URL. Full text. Morris J, Laing-Morton T, Marno P, Curnow A (2011). An investigation into the awareness and understanding of the ultraviolet index forecasts in the South West of England. Photochem. Photobiol. Sci. Abstract. Tyrrell JS, Morton C, Campbell SM, Curnow A (2011). Comparison of protoporphyrin IX accumulation and destruction during methylaminolevulinate photodynamic therapy of skin tumours located at acral and nonacral sites. Br J Dermatol, 164(6), 1362-1368. Abstract. Author URL. Full text. Tyrrell J, Campbell SM, Curnow A (2011). Monitoring the accumulation and dissipation of the photosensitizer protoporphyrin IX during standard dermatological methyl-aminolevulinate photodynamic therapy utilizing non-invasive fluorescence imaging and quantification. Photodiagnosis Photodyn Ther, 8(1), 30-38. Abstract. Author URL. Full text. Tyrrell J, Thorn C, Shore A, Campbell S, Curnow A (2011). Oxygen saturation and perfusion changes during dermatological methyl-aminolevulinate photodynamic therapy. British Journal of Dermatology Full text. Tyrrell J, Campbell SM, Curnow A (2011). The effect of air cooling pain relief on protoporphyrin IX photobleaching and clinical efficacy during dermatological photodynamic therapy. J Photochem Photobiol B, 103(1), 1-7. Abstract. Author URL. Article has an altmetric score of 7 Curnow A, Campbell SM (2010). Clinical investigation of the novel iron-chelating agent, CP94, to enhance topical photodynamic therapy of nodular basal cell carcinoma: further explanation of a dose-escalating pilot study conducted primarily to consider the safety of this pharmacological modification. Br J Dermatol, 162(1), 224-225. Author URL. Campbell SM, Tyrrell J, Marshall R, Curnow A (2010). Effect of MAL-photodynamic therapy on hypertrophic scarring. Photodiagnosis Photodyn Ther, 7(3), 183-188. Abstract. Author URL. Tyrrell J, Campbell S, Curnow A (2010). Protoporphyrin IX photobleaching during the light irradiation phase of standard dermatological methyl-aminolevulinate photodynamic therapy. Photodiagnosis Photodyn Ther, 7(4), 232-238. Abstract. Author URL. Blake E, Curnow A (2010). The hydroxypyridinone iron chelator CP94 can enhance PpIX-induced PDT of cultured human glioma cells. Photochem Photobiol, 86(5), 1154-1160. Abstract. Author URL. Tyrrell JS, Campbell SM, Curnow A (2010). The relationship between protoporphyrin IX photobleaching during real-time dermatological methyl-aminolevulinate photodynamic therapy (MAL-PDT) and subsequent clinical outcome. Lasers Surg Med, 42(7), 613-619. Abstract. Author URL. Full text.