Cory, Giles - University of Exeter

个人简介

1992 - BA (Hons) Biochemistry - University of Oxford. 1997 - Ph.D - Molecular Interactions of Bruton‘s Tyrosine kinase - Institute of Child Health, University College, London. 2013 - Fellow of the Higher Education Academy.

研究领域

After completing his undergraduate degree in Biochemistry, Giles embarked on a Ph.D at the Institute of Child Health in London, where under the supervision of Professor Christine Kinnon, he investigated the function of proteins shown to be defective or missing in inherited immune-deficiency diseases. During this work it became clear that several of these proteins had a role in controlling the cytoskeleton of cells - a dynamic meshwork that controls cell shape and movement. Giles pursued this interest during his post-doctoral work with Professor Anne Ridley at the Ludwig institute for Cancer Research. The spread of tumours to secondary sites in the body results from the ability of some cancer cells to break free and crawl through tissue to the highways of the blood and lymphatic systems before they squeeze out and invade new tissue. This ability of cells to crawl through tissue (or ‘cell migration‘) is totally dependent upon the coordinated formation and destruction of regions of the cytoskeleton which act to push and pull the cell forwards. Giles‘s work helped identify how cells control their cytoskeleton in response to signals that can be elevated in cancer, focusing on the function of a protein called WASP. This work formed the basis of a successful application for a Wellcome Trust Career Development Fellowship which Giles undertook at the University of Bristol, studying the control of cell migration by another cytoskeletal regulator called WAVE. This work continues at the University of Exeter Medical School where Giles uses state-of-the-art microscopy techniques to elucidate the mechanisms of cell migration in health and disease.

近期论文

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Worth AJJ, Metelo J, Bouma G, Moulding D, Fritzsche M, Vernay B, Charras G, Cory GOC, Thrasher AJ, Burns SO, et al (2013). Disease-associated missense mutations in the EVH1 domain disrupt intrinsic WASp function causing dysregulated actin dynamics and impaired dendritic cell migration. Blood, 121(1), 72-84. Abstract. Macpherson L, Monypenny J, Blundell MP, Cory GO, Tomé-García J, Thrasher AJ, Jones GE, Calle Y (2012). Tyrosine phosphorylation of WASP promotes calpain-mediated podosome disassembly. Haematologica, 97(5), 687-691. Abstract. Author URL. Cory G (2011). Scratch-wound assay. Methods Mol Biol, 769, 25-30. Abstract. Author URL. Blundell MP, Bouma G, Metelo J, Worth A, Calle Y, Cowell LA, Westerberg LS, Moulding DA, Mirando S, Kinnon C, et al (2009). Phosphorylation of WASp is a key regulator of activity and stability in vivo. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 106(37), 15738-15743. Author URL. Article has an altmetric score of 1 Pocha SM, Cory GO (2009). WAVE2 is regulated by multiple phosphorylation events within its VCA domain. Cell Motility and the Cytoskeleton, 66(1), 36-47. Abstract. Full text. Worth AJJ, Cory GOC, Thrasher AJ, Burns S (2008). Molecular pathogenesis of Wiskott-Aldrich syndrome mutations: insights into the mechanisms of endritic cell migration. CLINICAL AND EXPERIMENTAL IMMUNOLOGY, 154, 71-72. Author URL. Cory G, Cullen PJ (2007). Membrane curvature: the power of bananas, zeppelins and boomerangs. Current Biology, 17(12), 455-457. Danson CM, Pocha SM, Bloomberg GB, Cory GO (2007). Phosphorylation of WAVE2 by MAP kinases regulates persistent cell migration and polarity. Journal of Cell Science, 120(23), 4144-4154. Abstract. Moulding DA, Blundell MP, Spiller DG, White MRH, Cory GO, Calle Y, Kempski H, Sinclair J, Ancliff PJ, Kinnon C, et al (2007). Unregulated actin polymerization by WASp causes defects of mitosis and cytokinesis in X-linked neutropenia. Journal of Experimental Medicine, 204(9), 2213-2224. Abstract. Ancliff PJ, Blundell MP, Cory GO, Calle Y, Worth A, Kempski H, Burns S, Jones GE, Sinclair J, Kinnon C, et al (2006). Two novel activating mutations in the Wiskott-Aldrich syndrome protein result in congenital neutropenia. BLOOD, 108(7), 2182-2189. Author URL. Burns S, Cory GO, Vainchenker W, Thrasher AJ (2004). Mechanisms of WASp-mediated hematologic and immunologic disease. BLOOD, 104(12), 3454-3462. Author URL. Cory GO, Cramer R, Blanchoin L, Ridley AJ (2003). Phosphorylation of the WASP-VCA domain increases its affinity for the Arp2/3 complex and enhances actin polymerization by WASP. Mol Cell, 11(5), 1229-1239. Cory GO, Ridley AJ (2002). Cell motility: braking WAVEs. Nature, 418(6899), 732-733. Author URL. Cory GO, Garg R, Cramer R, Ridley AJ (2002). Phosphorylation of tyrosine 291 enhances the ability of WASp to stimulate actin polymerization and filopodium formation. Wiskott-Aldrich Syndrome protein. J Biol Chem, 277(47), 45115-45121. Abstract. Author URL. Morrogh LM, Hinshelwood S, Costello P, Cory G, Kinnon C (1999). The SH3 domain of Bruton's tyrosine kinase displays altered ligand binding properties when auto-phosphorylated in vitro. Eur J Immunol, 29(7), 2269-2279. Kinnon C, Cory GO, MacCarthy-Morrogh L, Banin S, Gout I, Lovering RC, Brickell PM (1997). The identification of Bruton's tyrosine kinase and Wiskott-Aldrich syndrome protein associated proteins and signalling pathways. Biochem Soc Trans, 25(2), 648-650. Author URL. Cory G, MacCarthy-Morrogh L, Banin S, Gout I, Brickell PM, Levinsky RJ, Kinnon C, Lovering RC (1996). Evidence that the Wiskott-Aldrich syndrome protein may be involved in lymphoid cel signalling pathways. J Immunol, 157(9), 3791-3795. Cory G, Lovering RC, Hinshelwood S, MacCarthy-Morrogh L, Levinsky RJ, Kinnon C (1995). The protein product of the c-cbl protooncogene is phosphorylated after B cell receptor stimulation and binds the SH3 domain of Bruton's tyrosine kinase. J Exp Med, 182(2), 611-615. Macpherson L, Monypenny J, Blundell MP, Cory GO, Tome-Garcia J, Thrasher A, Jones GE, Calle Y (2010). Tyrosine Phosphorylation of WASP Promotes Calpain-Mediated Podosome Disassembly in Myeloid Cells. Author URL.