Brown, Jon - University of Exeter

个人简介

PhD, 2004, University of Bristol MRes, 2000, University of Manchester BSc Neuroscience (1st class), 1999, University of Manchester

研究领域

Cognitive dysfunction in neurological diseases such as Alzheimer’s disease (AD) and frontotemporal dementia arise from changes to neuronal networks. For example, in late-stage AD, there is substantial neurodegeneration which alters the integrity of the surviving network. Furthermore, there is increasing evidence that more subtle changes to synaptic circuits may underlie the cognitive deficits that occur earlier on in the disease, prior to detectable neuronal loss. Dr Brown and his colleagues aim to characterize these changes in neuronal networks at multiple levels of complexity, using mouse models of dementia and schizophrenia. They make whole-cell recordings from neurons in brain areas known to be affected in these diseases, such as the hippocampus, entorhinal cortex and prefrontal cortex. They use these approaches to explore the synaptic and intrinsic properties of these neurons. More recently they have been using recording techniques that allow them to record network activity from multiple brain regions simultaneously, to explore the impact of cellular level changes on larger scale network interactions.

近期论文

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Martin HG, Lassalle O, Brown JT, Manzoni OJ (2016). Age-Dependent Long-Term Potentiation Deficits in the Prefrontal Cortex of the Fmr1 Knockout Mouse Model of Fragile X Syndrome. Cereb Cortex, 26(5), 2084-2092. Abstract. Author URL. Full text. Article has an altmetric score of 1 Booth CA, Witton J, Nowacki J, Tsaneva-Atanasova K, Jones MW, Randall AD, Brown JT (2016). Altered Intrinsic Pyramidal Neuron Properties and Pathway-Specific Synaptic Dysfunction Underlie Aberrant Hippocampal Network Function in a Mouse Model of Tauopathy. J Neurosci, 36(2), 350-363. Abstract. Author URL. Full text. Article has an altmetric score of 16 Booth CA, Ridler T, Murray TK, Ward MA, de Groot E, Goodfellow M, Phillips KG, Randall AD, Brown JT (2016). Electrical and Network Neuronal Properties Are Preferentially Disrupted in Dorsal, But Not Ventral, Medial Entorhinal Cortex in a Mouse Model of Tauopathy. J Neurosci, 36(2), 312-324. Abstract. Author URL. Full text. Article has an altmetric score of 13 Telezhkin V, Schnell C, Yarova P, Yung S, Cope E, Hughes A, Thompson BA, Sanders P, Geater C, Hancock JM, et al (2016). Forced cell cycle exit and modulation of GABAA, CREB, and GSK3β signaling promote functional maturation of induced pluripotent stem cell-derived neurons. Am J Physiol Cell Physiol, 310(7), C520-C541. Abstract. Author URL. Article has an altmetric score of 4 Dawson N, Kurihara M, Thomson DM, Winchester CL, McVie A, Hedde JR, Randall AD, Shen S, Seymour PA, Hughes ZA, et al (2015). Altered functional brain network connectivity and glutamate system function in transgenic mice expressing truncated Disrupted-in-Schizophrenia 1. Transl Psychiatry, 5 Abstract. Author URL. Full text. Article has an altmetric score of 71 Tamagnini F, Novelia J, Kerrigan TL, Brown JT, Tsaneva-Atanasova KT, Randall AD (2015). Altered intrinsic excitability of hippocampal CA1 pyramidal neurons in aged PDAPP mice. Front. Cell. Neurosci., 9 Full text. Article has an altmetric score of 11 Banks PJ, Burroughs AC, Barker GR, Brown JT, Warburton EC, Bashir ZI (2015). Disruption of hippocampal-prefrontal cortex activity by dopamine D2R-dependent LTD of NMDAR transmission. Proc Natl Acad Sci U S A, 112(35), 11096-11101. Abstract. Author URL. Full text. Article has an altmetric score of 19 Witton J, Padmashri R, Zinyuk LE, Popov VI, Kraev I, Line SJ, Jensen TP, Tedoldi A, Cummings DM, Tybulewicz VL, et al (2015). Hippocampal circuit dysfunction in the Tc1 mouse model of Down syndrome. Nat Neurosci, 18(9), 1291-1298. Abstract. Author URL. Full text. Article has an altmetric score of 51 Tamagnini F, Scullion S, Brown JT, Randall AD (2015). Intrinsic excitability changes induced by acute treatment of hippocampal CA1 pyramidal neurons with exogenous amyloid β peptide. Hippocampus, 25(7), 786-797. Full text. Church TW, Weatherall KL, Corrêa SA, Prole DL, Brown JT, Marrion NV (2015). Preferential assembly of heteromeric small conductance calcium-activated potassium channels. Eur J Neurosci, 41(3), 305-315. Abstract. Author URL. Article has an altmetric score of 1 Kerrigan TL, Brown JT, Randall AD (2014). Characterization of altered intrinsic excitability in hippocampal CA1 pyramidal cells of the Aβ-overproducing PDAPP mouse. Neuropharmacology, 79, 515-524. Abstract. Author URL. Witton J, Staniaszek LE, Bartsch U, Randall AD, Jones MW, Brown JT (2014). Disrupted hippocampal sharp-wave ripple-associated spike dynamics in a transgenic mouse model of dementia. The Journal of Physiology, n/a-n/a. Full text. Randall AD, Kurihara M, Brandon NJ, Brown JT (2014). Disrupted in schizophrenia 1 and synaptic function in the mammalian central nervous system. Eur J Neurosci, 39(7), 1068-1073. Abstract. Author URL. Article has an altmetric score of 1 Tamagnini F, Scullion S, Brown JT, Randall AD (2014). Low concentrations of the solvent dimethyl sulphoxide alter intrinsic excitability properties of cortical and hippocampal pyramidal cells. PLoS One, 9(3). Abstract. Author URL. Booth CA, Brown JT, Randall AD (2014). Neurophysiological modification of CA1 pyramidal neurons in a transgenic mouse expressing a truncated form of disrupted-in-schizophrenia 1. Eur J Neurosci, 39(7), 1074-1090. Abstract. Author URL. Article has an altmetric score of 2 Corbett BF, Leiser SC, Ling H-P, Nagy R, Breysse N, Zhang X, Hazra A, Brown JT, Randall AD, Wood A, et al (2013). Sodium channel cleavage is associated with aberrant neuronal activity and cognitive deficits in a mouse model of Alzheimer’s disease. The Journal of neuroscience : the official journal of the Society for Neuroscience, 33, 7020-6. Abstract. Brown J, Hainsworth AH, Stefani A, Randall AD (2013). Whole-cell patch-clamp recording of voltage-sensitive Ca²⁺ channel currents in single cells: heterologous expression systems and neurones. Methods Mol Biol, 937, 123-148. Abstract. Author URL. Randall AD, Booth C, Brown JT (2012). Age-related changes to Na+ channel gating contribute to modified intrinsic neuronal excitability. Neurobiol Aging, 33(11), 2715-2720. Abstract. Author URL. Article has an altmetric score of 10 Forsyth LH, Witton J, Brown JT, Randall AD, Jones MW (2012). In Vitro and in Vivo Recording of Local Field Potential Oscillations in Mouse Hippocampus. Curr Protoc Mouse Biol, 2(3), 273-294. Abstract. Author URL. Nowacki J, Osinga HM, Brown JT, Randall AD, Tsaneva-Atanasova K (2011). A unified model of CA1/3 pyramidal cells: an investigation into excitability. Prog Biophys Mol Biol, 105(1-2), 34-48. Abstract. Author URL.