Beall, Craig - University of Exeter

个人简介

Dr Craig Beall completed his degree in Pharmacology (BSc Hons; University of Dundee) in 2003 before obtaining a Wellcome Trust Prize Studentship to undertake doctoral studies in the laboratory of Prof Mike Ashford, University of Dundee. Doctoral studies focused on mechanisms of glucose sensing in pancreatic beta cells and hypothalamic neurons, with a particular focus on AMP-activated protein kinase and ATP-sensitive K+ channels. Following a year in at the University of Liverpool investigating the role of K+ channels in skeletal muscle insulin sensitivity, Dr Beall moved back to the University of Dundee to work with Professors Rory McCrimmon and Prof Ashford to focus on mechanisms of hypoglycaemia detection. Dr Beall was a recipient of a Juvenile Diabetes Research Foundation postdoctoral fellowship (2010-2013) to develop and establish an in vitro model for investigating the mechanisms of hypothalamic glucose sensing.

研究领域

The Beall laboratory is interested in the complex adaptive responses to acute and recurrent hypoglycaemia, which is still a frequent concern for people with type 1 and advanced (insulin-treated) type 2 diabetes. The lab focuses on deciphering the neuronal and glial responses to hypoglycaemia and the communication between both cell types. Working with Dr Kate Ellacott, we are also interested in astrocyte-neuron communication during energy excess, such as a high fat diet and whether astrocytes play in a role in regulating feeding behaviour. In collaboration with Prof Andrew Randall and Dr Ritchie Williamson, we are investigating how glucose variation alters signalling processes in human neural cells and how this relates to dementia risk. In collaboration with Dr Benjamin Wall, we are examining the pathways that are altered in muscle by glucose/lipid variation and how this may relate to aging and diabetes-induced analbolic resistance (the inability to make enough muscle protein to maintain strength and function).

近期论文

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Walker JMV, Malhi A, Hardy H, Chilton J, Beall C (2016). A769662 regulates intracellular calcium and extracellular ATP independent of AMPK. DIABETIC MEDICINE, 33, 50-50. Author URL. Cameron AR, Morrison VL, Levin D, Mohan M, Forteath C, Beall C, McNeilly AD, Balfour DJ, Savinko T, Wong AK, et al (2016). Anti-Inflammatory Effects of Metformin Irrespective of Diabetes Status. Circ Res, 119(5), 652-665. Abstract. Author URL. Full text. Article has an altmetric score of 38 Yavari A, Stocker CJ, Ghaffari S, Wargent ET, Steeples V, Czibik G, Pinter K, Bellahcene M, Woods A, Martínez de Morentin PB, et al (2016). Chronic Activation of γ2 AMPK Induces Obesity and Reduces β Cell Function. Cell Metab, 23(5), 821-836. Abstract. Author URL. Full text. Article has an altmetric score of 20 Haythorne E, Hamilton DL, Findlay JA, Beall C, McCrimmon RJ, Ashford ML (2016). Chronic exposure to KATP channel openers results in attenuated glucose sensing in hypothalamic GT1-7 neurons. Neuropharmacology, 111, 212-222. Abstract. Author URL. Full text. Article has an altmetric score of 10 Walker JV, Ashford MLJ, McCrimmon RJ, Beall C (2016). Exposure of astrocytes to recurrent low glucose delays AMPK phosphorylation and alters ATP and lactate release. DIABETIC MEDICINE, 33, 54-54. Author URL. Beall C, Walker JMV, Ashford MLJ, McCrimmon RJ (2015). A critical role for AMP-activated protein kinase in regulation of gliotransmitter release from astrocytes. DIABETIC MEDICINE, 32, 62-62. Author URL. Cameron AR, Morrison V, McNeilly AD, Forteath C, Beall C, Stewart CA, Balfour DJK, Sutherland CD, Sakamoto K, Fagerholm SC, et al (2015). Anti-inflammatory effects of metformin. DIABETIC MEDICINE, 32, 54-55. Author URL. Cameron A, Forteath C, Beall C, Rena G (2015). Anti-inflammatory effects of metformin and their relationship to the therapeutic action of the drug. Endocrine Abstracts Walker JV, Ashford M, McCrimmon R, Beall C (2015). Characterisation of the astrocytic response to acute and recurrent hypoglycaemia. Endocrine Abstracts Walker JMV, Gabriel J, Ashford MLJ, McCrimmon RJ, Beall C (2015). Modulation of astrocytic lactate release during hypoglycaemia by AMP-activated protein kinase and noradrenaline. DIABETIC MEDICINE, 32, 62-63. Author URL. Hamilton DL, Beall C, Jeromson S, Chevtzoff C, Cuthbertson DJ, Ashford ML (2014). Kv1.3 inhibitors have differential effects on glucose uptake and AMPK activity in skeletal muscle cell lines and mouse ex vivo skeletal muscle. J Physiol Sci, 64(1), 13-20. Abstract. Author URL. Article has an altmetric score of 6 Beall C, Watterson KR, McCrimmon RJ, Ashford ML (2013). AMPK modulates glucose-sensing in insulin-secreting cells by altered phosphotransfer to KATP channels. J Bioenerg Biomembr, 45(3), 229-241. Abstract. Author URL. Article has an altmetric score of 3 Beall C, Haythorne E, Fan X, Du Q, Jovanovic S, Sherwin RS, Ashford ML, McCrimmon RJ (2013). Continuous hypothalamic K(ATP) activation blunts glucose counter-regulation in vivo in rats and suppresses K(ATP) conductance in vitro. Diabetologia, 56(9), 2088-2092. Abstract. Author URL. Ashford M, Beall C, McCrimmon R (2012). Hypoglycaemia: exercise for the brain?. J Neuroendocrinol, 24(10), 1365-1366. Abstract. Author URL. Beall C, Hamilton DL, Gallagher J, Logie L, Wright K, Soutar MP, Dadak S, Ashford FB, Haythorne E, Du Q, et al (2012). Mouse hypothalamic GT1-7 cells demonstrate AMPK-dependent intrinsic glucose-sensing behaviour. Diabetologia, 55(9), 2432-2444. Abstract. Author URL. Full text. Article has an altmetric score of 6 Beall C, Ashford ML, McCrimmon RJ (2012). The physiology and pathophysiology of the neural control of the counterregulatory response. Am J Physiol Regul Integr Comp Physiol, 302(2), R215-R223. Abstract. Author URL. Article has an altmetric score of 6 Beall C, Piipari K, Al-Qassab H, Smith MA, Parker N, Carling D, Viollet B, Withers DJ, Ashford ML (2010). Loss of AMP-activated protein kinase alpha2 subunit in mouse beta-cells impairs glucose-stimulated insulin secretion and inhibits their sensitivity to hypoglycaemia. Biochem J, 429(2), 323-333. Abstract. Author URL. Full text. Article has an altmetric score of 5 Piipari K, Beall C, Al-Qassab H, Smith MA, Carling D, Viollet B, Ashford MLJ, Withers DJ (2010). Key Role of AMP-Activated Protein Kinase in Pancreatic Beta Cell Glucose-Sensing and Whole Body Glucose Homeostasis. Author URL.