Williams, Bryony - University of Exeter - Disciplines of Biosciences

个人简介

1999-2002 PhD The Natural History Museum London and University College London 1997-1998 MSc Advanced Methods in Taxonomy and Biodiversity, The Natural History Museum London and Imperial College London 1994-1997 BSc Biology, Southampton University Career 2007-Present Research Fellow, (Royal Society) School of Biosciences, University of Exeter 2007 Human Frontier Science Foundation Short Term Fellow, Rutgers, Newark, USA 2002-2007 Postdoctoral Fellow, University of British Columbia, Canada

研究领域

My current research concerns the biology of microsporidia. These are highly unusual fungi and obligate intracellular parasites of many different lineages of animals, including humans. Though eukaryotic, microsporidia have very small genomes and cryptic mitochondria that produce no ATP. My past research has sought to understand the nature of reduction microsporidian genomes and mitochondria. I have studied the variability of genome architecture between different species of microsporidia and looked at the effects of genome compaction and reduction on the process of gene transcription. As intracellular parasites, microsporidia have diverse effects on their host cells. Metabolite import and parasite development is facilitated by manipulation of the host cell cytoskeleton. For example, in many species, host mitochondria are drawn around the cell, most likely to aid the uptake of ATP directly from the host cell. I am currently trying to understand how microsporidia affect host cell function by identifying and characterizing proteins at the host-parasite interface and those secreted from the parasite cell.

近期论文

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Williams TA, Nakjang S, Campbell SE, Freeman MA, Eydal M, Moore K, Hirt RP, Embley TM, Williams BAP (In Press). A recent whole-genome duplication divides populations of a globally-distributed microsporidian. Molecular Biology and Evolution Abstract. Full text. Article has an altmetric score of 6 Stentiford GD, Becnel JJ, Weiss LM, Keeling PJ, Didier ES, Williams BAP, Bjornson S, Kent ML, Freeman MA, Brown MJF, et al (2016). Microsporidia – Emergent Pathogens in the Global Food Chain. Trends in Parasitology, 32(4), 336-348. Full text. Article has an altmetric score of 66 Bateman KS, Wiredu-Boakye D, Kerr R, Williams BAP, Stentiford GD (2016). Single and multi-gene phylogeny of Hepatospora (Microsporidia) – a generalist pathogen of farmed and wild crustacean hosts. Parasitology (Cambridge) Abstract. Article has an altmetric score of 5 Watson AK, Williams TA, Williams BAP, Moore KA, Hirt RP, Embley TM (2015). Transcriptomic profiling of host-parasite interactions in the microsporidian Trachipleistophora hominis. BMC Genomics Abstract. Full text. Article has an altmetric score of 2 Read BA, Kegel J, Klute MJ, Kuo A, Lefebvre SC, Maumus F, Mayer C, Miller J, Monier A, Salamov A, et al (2013). Pan genome of the phytoplankton Emiliania underpins its global distribution. Nature, 499(7457), 209-213. Abstract. Author URL. Article has an altmetric score of 109 Campbell SE, Williams TA, Yousuf A, Soanes DM, Paszkiewicz KH, Williams BAP (2013). The Genome of Spraguea lophii and the Basis of Host-Microsporidian Interactions. PLoS Genet, 9(8). Abstract. Author URL. Article has an altmetric score of 19 Williams BAP, Elliot C, Burri L, Kido Y, Kita K, Moore AL, Keeling PJ (2010). A broad distribution of the alternative oxidase in microsporidian parasites. PLoS Pathogens, 6(2). Abstract. Full text. Williams BAP (2009). Unique physiology of host-parasite interactions in microsporidia infections. Cellular Microbiology, 11(11), 1551-1560. Abstract. Lee RC, Williams BA, Brown AM, Adamson ML, Keeling PJ, Fast NM (2008). Alpha- and beta-tubulin phylogenies support a close relationship between the microsporidia Brachiola algerae and Antonospora locustae. J Eukaryot Microbiol, 55(5), 388-392. Abstract. Author URL. Williams BA, Haferkamp I, Keeling PJ (2008). An ADP/ATP-specific mitochondrial carrier protein in the microsporidian Antonospora locustae. J Mol Biol, 375(5), 1249-1257. Abstract. Author URL. Williams BA, Cali A, Takvorian PM, Keeling PJ (2008). Distinct localization patterns of two putative mitochondrial proteins in the microsporidian Encephalitozoon cuniculi. J Eukaryot Microbiol, 55(2), 131-133. Abstract. Author URL. Williams BA, Lee RC, Becnel JJ, Weiss LM, Fast NM, Keeling PJ (2008). Genome sequence surveys of Brachiola algerae and Edhazardia aedis reveal microsporidia with low gene densities. BMC Genomics, 9 Abstract. Author URL. Full text. Lee RCH, Williams BAP, Brown AMV, Adamson ML, Keeling PJ, Fast NM (2008). α- and β-tubulin phylogenies support a close relationship between the microsporidia Brachiola algerae and Antonospora locustae. Journal of Eukaryotic Microbiology, 55(5), 388-392. Abstract. Weiss, L.M. Feng, X. Williams, B.A. (2007). Analysis of the beta-tubulin genes from Enterocytozoon bieneusi isolates from a human and rhesus macaque. J Eukaryot Microbiol, 54, 38-41. Burri L, Williams BA, Bursac D, Lithgow T, Keeling PJ (2006). Microsporidian mitosomes retain elements of the general mitochondrial targeting system. Proc Natl Acad Sci U S A, 103(43), 15916-15920. Abstract. Author URL. Article has an altmetric score of 1 Williams BA, Slamovits CH, Patron NJ, Fast NM, Keeling PJ (2005). A high frequency of overlapping gene expression in compacted eukaryotic genomes. Proc Natl Acad Sci U S A, 102(31), 10936-10941. Abstract. Author URL. Article has an altmetric score of 1 Keeling PJ, Fast NM, Law JS, Williams BA, Slamovits CH (2005). Comparative genomics of microsporidia. Folia Parasitol (Praha), 52(1-2), 8-14. Abstract. Author URL. Williams BA, Keeling PJ (2005). Microsporidian mitochondrial proteins: expression in Antonospora locustae spores and identification of genes coding for two further proteins. J Eukaryot Microbiol, 52(3), 271-276. Abstract. Author URL. Williams BA, Hirt RP (2004). RACE and RAGE cloning in parasitic microbial eukaryotes. Methods Mol Biol, 270, 151-172. Abstract. Author URL. Slamovits CH, Williams BA, Keeling PJ (2004). Transfer of Nosema locustae (Microsporidia) to Antonospora locustae n. comb. based on molecular and ultrastructural data. J Eukaryot Microbiol, 51(2), 207-213. Abstract. Author URL.