Westra, Edze - University of Exeter - Disciplines of Biosciences

个人简介

2016 Heineken Young Scientist Award for Biochemistry and Biophysics (awarded by the KNAW, the Dutch royal society for science) 2014 Westerdijk Award for best Ph.D. research in Microbiology in the Netherlands (awarded by the KNVM, the Dutch society for microbiology) 2013 Westenbrink Award for best Ph.D. research in Biochemistry in the Netherlands (awarded by the NVBMB, the Dutch society for biochemistry and molecular biology) 2013 PhD Microbiology (University of Wageningen) 2007 MSc Molecular Life Sciences (University of Wageningen) 2006 BSc Molecular Life Sciences (University of Wageningen)

研究领域

I am a NERC funded Independent Senior Research Fellow, working on the evolutionary ecology of host-parasite interactions. I use bacteria-phage and bacteria-plasmid interactions as a model system to study how ecological variables drive the evolution of various immune strategies, and to examine their coevolutionary consequences. Bacteria, phage and plasmids are an ideal model system because bacteria encode lots of different immune mechanisms, and their molecular basis has been studied in great detail. Bacterial defense mechanisms include CRISPR-Cas, which I studied at the molecular level during the start of my scientific career, surface modification, restriction modification, abortive infection and prokaryotic Argonaute.

近期论文

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van Houte S, Buckling A, Westra ER (2016). Evolutionary Ecology of Prokaryotic Immune Mechanisms. Microbiol Mol Biol Rev, 80(3), 745-763. Abstract. Author URL. Full text. Article has an altmetric score of 8 Bondy-Denomy J, Qian J, Westra ER, Buckling A, Guttman DS, Davidson AR, Maxwell KL (2016). Prophages mediate defense against phage infection through diverse mechanisms. ISME J Abstract. Author URL. Article has an altmetric score of 23 van Houte S, Ekroth AK, Broniewski JM, Chabas H, Ashby B, Bondy-Denomy J, Gandon S, Boots M, Paterson S, Buckling A, et al (2016). The diversity-generating benefits of a prokaryotic adaptive immune system. Nature, 532(7599), 385-388. Abstract. Author URL. Full text. Article has an altmetric score of 114 Swarts DC, Koehorst JJ, Westra ER, Schaap PJ, van der Oost J (2015). Effects of Argonaute on Gene Expression in Thermus thermophilus. PLoS One, 10(4). Abstract. Author URL. Article has an altmetric score of 3 Künne T, Westra ER, Brouns SJ (2015). Electrophoretic Mobility Shift Assay of DNA and CRISPR-Cas Ribonucleoprotein Complexes. Methods Mol Biol, 1311, 171-184. Abstract. Author URL. Westra ER, van Houte S, Oyesiku-Blakemore S, Makin B, Broniewski JM, Best A, Bondy-Denomy J, Davidson A, Boots M, Buckling A, et al (2015). Parasite Exposure Drives Selective Evolution of Constitutive versus Inducible Defense. Curr Biol, 25(8), 1043-1049. Abstract. Author URL. Article has an altmetric score of 26 Westra ER, Van houte S, Oyesiku-Blakemore S, Makin B, Broniewski JM, Best A, Bondy-Denomy J, Davidson A, Boots M, Buckling A, et al (2015). Parasite exposure drives selective evolution of constitutive versus inducible defense. Current Biology, 25(8), 1043-1049. Abstract. Article has an altmetric score of 26 Blosser TR, Loeff L, Westra ER, Vlot M, Künne T, Sobota M, Dekker C, Brouns SJ, Joo C (2015). Two distinct DNA binding modes guide dual roles of a CRISPR-Cas protein complex. Mol Cell, 58(1), 60-70. Abstract. Author URL. Article has an altmetric score of 2 Westra ER, Buckling A, Fineran PC (2014). CRISPR-Cas systems: Beyond adaptive immunity. Nature Reviews Microbiology, 12(5), 317-326. Abstract. Article has an altmetric score of 25 Westra ER, Buckling A, Fineran PC (2014). CRISPR-Cas systems: beyond adaptive immunity. Nat Rev Microbiol, 12(5), 317-326. Abstract. Author URL. Article has an altmetric score of 25 Swarts DC, Jore MM, Westra ER, Zhu Y, Janssen JH, Snijders AP, Wang Y, Patel DJ, Berenguer J, Brouns SJJ, et al (2014). DNA-guided DNA interference by a prokaryotic Argonaute. Nature, 507(7491), 258-261. Abstract. Article has an altmetric score of 43 Swarts DC, Jore MM, Westra ER, Zhu Y, Janssen JH, Snijders AP, Wang Y, Patel DJ, Berenguer J, Brouns SJ, et al (2014). DNA-guided DNA interference by a prokaryotic Argonaute. Nature, 507(7491), 258-261. Abstract. Author URL. Article has an altmetric score of 43 Jackson RN, Golden SM, van Erp PBG, Carter J, Westra ER, Brouns SJJ, van der Oost J, Terwilliger TC, Read RJ, Wiedenheft B, et al (2014). Structural biology. Crystal structure of the CRISPR RNA-guided surveillance complex from Escherichia coli. Science (New York, N.Y.), 345(6203), 1473-1479. Abstract. Article has an altmetric score of 131 Jackson RN, Golden SM, van Erp PB, Carter J, Westra ER, Brouns SJ, van der Oost J, Terwilliger TC, Read RJ, Wiedenheft B, et al (2014). Structural biology. Crystal structure of the CRISPR RNA-guided surveillance complex from Escherichia coli. Science, 345(6203), 1473-1479. Abstract. Author URL. Article has an altmetric score of 131 Van Der Oost J, Westra ER, Jackson RN, Wiedenheft B (2014). Unravelling the structural and mechanistic basis of CRISPR-Cas systems. Nature Reviews Microbiology, 12(7), 479-492. Abstract. Article has an altmetric score of 13 van der Oost J, Westra ER, Jackson RN, Wiedenheft B (2014). Unravelling the structural and mechanistic basis of CRISPR-Cas systems. Nat Rev Microbiol, 12(7), 479-492. Abstract. Author URL. Article has an altmetric score of 13 Ruigrok VJ, Westra ER, Brouns SJ, Escudé C, Smidt H, van der Oost J (2013). A capture approach for supercoiled plasmid DNA using a triplex-forming oligonucleotide. Nucleic Acids Res, 41(10). Abstract. Author URL. Westra ER, Staals RH, Gort G, Høgh S, Neumann S, de la Cruz F, Fineran PC, Brouns SJ (2013). CRISPR-Cas systems preferentially target the leading regions of MOBF conjugative plasmids. RNA Biol, 10(5), 749-761. Abstract. Author URL. Article has an altmetric score of 1 Ruigrok VJB, Westra ER, Brouns SJJ, Escudé C, Smidt H, Van Der Oost J (2013). The role of DNA bending in type IIA topoisomerase function. Nucleic Acids Research, 41(10). Abstract. Westra ER, Semenova E, Datsenko KA, Jackson RN, Wiedenheft B, Severinov K, Brouns SJ (2013). Type I-E CRISPR-cas systems discriminate target from non-target DNA through base pairing-independent PAM recognition. PLoS Genet, 9(9). Abstract. Author URL.