Wakefield, James - University of Exeter - Disciplines of Biosciences

个人简介

1999 PhD Wellcome/CRUK Institute for Cancer Research and Developmental Biology, University of Cambridge, UK 1995 BSc (Hons) in Biochemistry, University of Bristol Career 2010-current Senior Lecturer in Cell Biology, School of Biosciences, University of Exeter 2007-2009 Director, Life Sciences Interface Doctoral Training Centre, University of Oxford 2004-2007 Lecturer in Biology (Deputy Director) Life Sciences Interface Doctoral Training Centre, University of Oxford 2003–2004 Departmental Lecturer in Biology / Co-ordinator, MSc in Integrative Biosciences, University of Oxford 2000-2002 MRC Postdoctoral Research Associate, University of Bristol 1999-2000 EU TMR Postdoctoral Research Associate, Dipartmento di Genetica e Biologie Molecolare, University of Rome, Italy

研究领域

My research interest has always been that of mitosis and cell division, stimulated by the fundamental beauty of the process as viewed using a fluorescence microscope, and its key role in diseases such as cancer. Cell division is orchestrated by two main microtubule (MT) based structures called the ‘spindle apparatus’ and the ‘central spindle’, which function at different times to co-ordinate this dynamic process. We want to understand how these systems organise themselves, and what governs the similarities and differences between them in diverse types of cell, at different stages of development, and during disease. In order to learn as much as possible, we take a multi-disciplinary approach, combining proteomics, bioinformatics and quantitative image analysis with qualitative, descriptive cell and developmental biology, and genetics. I am a member of the Cell Biology research group.

近期论文

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Palumbo V, Pellacani C, Heesom KJ, Rogala KB, Deane CM, Mottier-Pavie V, Gatti M, Bonaccorsi S, Wakefield JG (2015). Misato Controls Mitotic Microtubule Generation by Stabilizing the Tubulin Chaperone Protein-1 Complex. Current Biology, 25(13), 1777-1783. Abstract. Article has an altmetric score of 2 Chen JW, Barker AR, Wakefield JG (2015). The Ran Pathway in Drosophila melanogaster Mitosis. Front Cell Dev Biol, 3 Abstract. Author URL. Article has an altmetric score of 2 Hayward D, Wakefield JG (2014). Chromatin-mediated microtubule nucleation in Drosophila syncytial embryos. Communicative and Integrative Biology, 7(4). Abstract. Article has an altmetric score of 3 Palumbo V, Pellacani C, Heesom KJ, Rogala KB, Deane CM, Mottier-Pavie V, Gatti M, Bonaccorsi S, Wakefield JG (2014). Misato Controls Mitotic Microtubule Generation by Stabilizing the Tubulin Chaperone Protein-1 Complex. Current Biology Abstract. Article has an altmetric score of 2 Hayward D, Metz J, Pellacani C, Wakefield JG (2014). Synergy between multiple microtubule-generating pathways confers robustness to centrosome-driven mitotic spindle formation. Dev Cell, 28(1), 81-93. Abstract. Author URL. Full text. Article has an altmetric score of 4 Duncan T, Wakefield JG (2011). 50 ways to build a spindle: the complexity of microtubule generation during mitosis. Chromosome Res, 19(3), 321-333. Abstract. Author URL. Wakefield JG (2011). Foreword: chromosomes and microtubules--the dynamic duo of mitosis. Chromosome Res, 19(3), 269-273. Author URL. Wainman A, Buster DW, Duncan T, Metz J, Ma A, Sharp D, Wakefield JG (2009). A new Augmin subunit, Msd1, demonstrates the importance of mitotic spindle-templated microtubule nucleation in the absence of functioning centrosomes. Genes Dev, 23(16), 1876-1881. Abstract. Author URL. Meireles AM, Fisher KH, Colombié N, Wakefield JG, Ohkura H (2009). Wac: a new Augmin subunit required for chromosome alignment but not for acentrosomal microtubule assembly in female meiosis. J Cell Biol, 184(6), 777-784. Abstract. Author URL. Hughes JR, Meireles AM, Fisher KH, Garcia A, Antrobus PR, Wainman A, Zitzmann N, Deane C, Ohkura H, Wakefield JG, et al (2008). A microtubule interactome: complexes with roles in cell cycle and mitosis. PLoS Biol, 6(4). Abstract. Author URL. Full text. Article has an altmetric score of 1 Buttrick GJ, Beaumont LM, Leitch J, Yau C, Hughes JR, Wakefield JG (2008). Akt regulates centrosome migration and spindle orientation in the early Drosophila melanogaster embryo. J Cell Biol, 180(3), 537-548. Abstract. Author URL. Full text. Gao S, Giansanti MG, Buttrick GJ, Ramasubramanyan S, Auton A, Gatti M, Wakefield JG (2008). Australin: a chromosomal passenger protein required specifically for Drosophila melanogaster male meiosis. J Cell Biol, 180(3), 521-535. Abstract. Author URL. Full text. Buttrick GJ, Wakefield JG (2008). PI3-K and GSK-3: Akt-ing together with microtubules. Cell Cycle, 7(17), 2621-2625. Abstract. Author URL. Fisher KH, Deane CM, Wakefield JG (2008). The functional domain grouping of microtubule associated proteins. Commun Integr Biol, 1(1), 47-50. Abstract. Author URL. Butcher RD, Chodagam S, Basto R, Wakefield JG, Henderson DS, Raff JW, Whitfield WG (2004). The Drosophila centrosome-associated protein CP190 is essential for viability but not for cell division. J Cell Sci, 117(Pt 7), 1191-1199. Abstract. Author URL. Wakefield JG, Stephens DJ, Tavaré JM (2003). A role for glycogen synthase kinase-3 in mitotic spindle dynamics and chromosome alignment. J Cell Sci, 116(Pt 4), 637-646. Abstract. Author URL. Tavaré JM, Fletcher LM, Oatey PB, Tyas L, Wakefield JG, Welsh GI (2001). Lighting up insulin action. Diabet Med, 18(4), 253-260. Abstract. Author URL. Wakefield JG, Bonaccorsi S, Gatti M (2001). The Drosophila protein Asp is involved in microtubule organization during spindle formation and cytokinesis. Journal of Cell Biology, 153(4), 637-647. Abstract. Raff JW, Huang JY, Wakefield JG (2000). A role for centrosomes in initiating the destruction of cyclin B in early Drosophila embryos. MOLECULAR BIOLOGY OF THE CELL, 11, 91A-91A. Author URL. Wakefield JG, Huang JY, Raff JW (2000). Centrosomes have a role in regulating the destruction of cyclin B in early Drosophila embryos. Curr Biol, 10(21), 1367-1370.