Brodbelt, Jennifer S. - The University of Texas at Austin

研究领域

The Brodbelt group focuses on the development and application of mass spectrometry to a variety of biological problems. We are interested in developing innovative methods for activating ions to generate informative fragmentation patterns, thus improving the structural characterization of proteins, nucleic acids, and lipids. We are also implementing strategies to increase the selectivity of mass spectrometry by incorporation of chromophores or trackable mass tags that allow targeted analysis of complex mixtures.

近期论文

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Top-Down 193-nm Ultraviolet Photodissociation Mass Spectrometry for Simultaneous Determination of Polyubiquitin Chain Length and Topology. Cannon, J.S., Martinez Fonts, K., Robotham, S.A., Matouschek, A., Brodbelt, J.S. Anal. Chem. Volume 87, 2015. Pages 1812-1820. Structural Characterization of Apo-Myoglobin by Ultraviolet Photodissociation. Cammarata, M., Brodbelt, J.S. Chemical Science Volume 6, 2015. Pages 1324-1333. Evolving tRNASec for efficient canonical incorporation of selenocysteine. Thyer, R., Robotham, S.A., Brodbelt, J.S., Ellington, A. J. Am. Chem. Soc. Volume 137(1), 2014. Pages 46-49. Improvement of Shotgun Proteomics in the Negative Mode by Carbamylation of Peptides and Ultraviolet Photodissociation Mass Spectrometry. Greer, S.M., Cannon, J.R, Brodbelt, J.S. Anal. Chem. Volume 86, 2014. Pages 12285-12290. Characterization of Pseudomonas aeruginosa LpxT reveals dual positional lipid A kinase activity and coordinated control of outer membrane modification. Nowicki, E., O’Brien, J.P., Brodbelt, J.S., Trent, M.S. Mol. Micro Volume 94(3), 2014. Pages 728-741. Covalent Inhibition of New Delhi Metallo-Beta-Lactamase-1 (NDM-1) by Cefaclor. Thomas, P.W., Cammarata, M., Brodbelt, J.S., Fast, W. ChemBioChem Volume 15(17), 2014. Pages 2541-2548. Antimicrobial Peptide Resistance of Vibrio cholerae Results From LPS Modification Pathway Related to Non-ribosomal Peptide Synthetases. Henderson, J., Fage, C.D., Cannon, J.R., Brodbelt, J.S., Keatinge-Clay, A.T., Trent, M.S. ACS Chemical Biology Volume 9(10), 2014. Pages 2382-2392. Hybridizing Ultraviolet Photodissociation with Electron Transfer Dissociation for Intact Protein Characterization. Cannon, J.R., Holden, D.D., Brodbelt, J.S. Anal. Chem Volume 86, 2014. Pages 10970-10977. The Molecular Mechanism of Eukaryotic Elongation Factor 2 Kinase Activation. Tavares, C., O’Brien, J., Brodbelt, J.S., Dalby, K. J. Biol Chem. Volume 289(34), 2014. Pages 23901-23916. Elucidation of Native Protein Complexes Using Ultraviolet Photodissociation Mass Spectrometry. O’Brien, J.P., Li, W., Zhang, Y., Brodbelt, J.S. J. Am. Chem. Soc. Volume 136, 2014. Pages 12920-12928. The First Pilot Project for the Consortium for Top Down Proteomics: A Status Report. Dang, X., Scotcher, J., Shaw, J., Ntai, I., Thomas, P.M., Fellers, R.X., Early, B.X., LeDuc, R.X., Wu, S., Zhang, Z., Tolic, N., Wolff, J.J., Easterling, M., Borchers, C.H., Brodbelt, J.S., Agar, J.N., Kelleher, N.L., Pasa-Tolic, L., Young., N.L. Proteomics Volume 14(10), 2014. Pages 1130-1140. Top-Down Ultraviolet Photodissociation for the structural elucidation of intact lipopolysaccharides. O’Brien, J.P.; Needham, B.; Brown D.; Trent, M.S.; Brodbelt, J.S. Chemical Science Volume 5, 2014. Pages 4291-4301. Streamlining Bottom-Up Protein Identification Based on Selective Ultraviolet Photodissociation (UVPD) of Chromophore-Tagged Histidine- and Tyrosine-Containing Peptides.. Aponte, J.R.; Vasicek, L.; Swaminathan, J.; Xu ,H.; Koag, M.C.; Lee, S.; Brodbelt, J.S. Analytical Chemistry Volume 86, 2014. Pages 6237-6244. Mechanically modulating the photophysical properties of fluorescent protein biocomposites for ratio- and intensiometric sensors.. Brantley, J.N.; Bailey, C.B.; Cannon, J.R.; Clark, K.A.; Vanden Bout, D.A.; Brodbelt, J.S.; Keatinge-Clay, A.T.; Bielawski, C.W. Angew Chem Int Ed Engl Volume 53, 2014. Pages 5088-5092. Direct Identification of Tyrosine Sulfation by using Ultraviolet Photodissociation Mass Spectrometry.. Robinson, M.R.; Moore, K.L.; Brodbelt, J.S. J Am Soc Mass Spectrom. Volume 25(8), 2014. Pages 1461-1471. Photodissociation mass spectrometry: new tools for characterization of biological molecules.. Brodbelt, J.S. Chem. Soc. Rev Volume 43, 2014. Pages 2757-2783. Probing the Unfolding of Myoglobin and Domain C of PARP-1 with Covalent Labeling and Top-Down 193 nm Ultraviolet Photodissociation Mass Spectrometry. Cammarata, M.; Lin, K.; Pruet, J.M.; Liu, H.; Brodbelt, J.S. Anal Chem Volume 86, 2014. Pages 2534-2542. Characterization of Green Fluorescent Proteins by 193 nm Ultraviolet Photodissociation Mass Spectrometry. Cannon, J.; Klue, C.; Ellington, A.; Brodbelt, J.S. Proteomics Volume 14(10), 2014. Pages 1165-1173. 193 nm Ultraviolet Photodissociation Mass Spectrometry for the Structural Elucidation of Lipid A Compounds in Complex Mixtures. O’Brien JP, Needham BD, Henderson JC, Nowicki EM, Trent MS, and Brodbelt JS Anal. Chem Volume 86, 2014. Pages 2138-2145. Ultraviolet Photodissociation for Characterization of Whole Proteins on a Chromatographic Timescale. Cannon JR, Cammarata MB, Robotham SA, Cotham VC, Shaw JB, Fellers RT, Early BP, Thomas PM, Kelleher NL, and Brodbelt JS Anal Chem Volume 86, 2014. Pages 2185-2192.