Giezen, Mark Van Der - University of Exeter - Disciplines of Biosciences

个人简介

2007 Certificate in Academic Practice, Queen Mary, University of London 1992-1997 PhD in Mathematical and Natural Sciences, University of Groningen 1988-1992 Drs Molecular Biology & Immunology, University of Groningen Career 2009 Visiting Scholar at the Institute for Protein Research, University of Osaka, Japan 2007-present Senior Lecturer in Evolutionary Biochemistry, School of Biosciences, University of Exeter 2004-2007 Lecturer in Microbiology, School of Biological and Chemical Sciences, Queen Mary, University of London 2002-2004 Postdoctoral Research Fellow, School of Biological Sciences, Royal Holloway, University of London 1998 EMBO Fellow 1997-2002 Postdoctoral Research Fellow, Department of Zoology, The Natural History Museum, London 1996 Visiting Scientist, Centre for the Study of Metals in Biology and Medicine, King‘s College, London 1992 Erasmus Studentship, Laboratoire de Microbiologie et Génétique Moléculaires, University Paul Sabatier, Toulouse

研究领域

In princple, my laboratory is a molecular parasitology lab which originally focused on the metabolic adaptations of microbial eukaryotes to low oxygen or complete lack of oxygen (see for examples: Nature 426, 172-176 and Current Biology 8, 580-585). Research includes major human pathogens such as Entamoeba histolytica, Trichomonas vaginalis and Blastocystis and our aim is to understand their unusual biochemistry as these might lead to new drug targets. New parasites in the group are those from the genus Aphanomyces. These parasites include causative agents of two notifyable diseases: crayfish plague and epizootic ulcerative syndrome in fish. In addition, we study microbial eukaryotes found in low-oxygen environments such as the rumen and termite hindgut as these micro-organisms have an extended repertoire of active enzymes that are useful for biofuel and other industrial purposes. Rumen microbes also play a major role in animal nutrition so this work has importance for food security as well. A recent new research direction involves the use of algae to regenerate mine waste, this is an extension of my involvement in the genome of Emiliania huxleyi (Nature 499, 209-213). My lab uses a variety of techniques to answer our research questions. Molecular biology, cell biology, biochemistry, bioinformatics and next-generation sequencing methods are routinely used.

近期论文

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van der Giezen M (2016). Evolution: Organelles Caught in the Act. Curr Biol, 26(20), R913-R915. Abstract. Author URL. Article has an altmetric score of 10 van der Giezen M (2015). Nature's Magic Algebra; or, How One Plus One Still Equaled One:. BioScience, 65(8), 832-833. Stairs CW, Eme L, Brown MW, Mutsaers C, Susko E, Dellaire G, Soanes DM, Van Der Giezen M, Roger AJ (2014). A SUF Fe-S cluster biogenesis system in the mitochondrion-related organelles of the anaerobic protist Pygsuia. Current Biology, 24(11), 1176-1186. Abstract. Article has an altmetric score of 10 Bertolini C, van Aerle R, Lampis S, Moore KA, Paszkiewicz K, Butler CS, Vallini G, van der Giezen M (2014). Draft Genome Sequence of Stenotrophomonas maltophilia SeITE02, a Gammaproteobacterium Isolated from Selenite-Contaminated Mining Soil. Genome Announc, 2(3). Abstract. Author URL. Article has an altmetric score of 4 van der Giezen M (2013). Evolution: one thread to unite them all. Curr Biol, 23(16), R679-R681. Abstract. Author URL. Article has an altmetric score of 2 Koumandou VL, Wickstead B, Ginger ML, van der Giezen M, Dacks JB, Field MC (2013). Molecular paleontology and complexity in the last eukaryotic common ancestor. Crit Rev Biochem Mol Biol, 48(4), 373-396. Abstract. Author URL. Article has an altmetric score of 3 Read BA, Kegel J, Klute MJ, Kuo A, Lefebvre SC, Maumus F, Mayer C, Miller J, Monier A, Salamov A, et al (2013). Pan genome of the phytoplankton Emiliania underpins its global distribution. Nature, 499(7457), 209-213. Abstract. Author URL. Article has an altmetric score of 109 Clark CG, van der Giezen M, Alfellani MA, Stensvold CR (2013). Recent developments in Blastocystis research. Adv Parasitol, 82, 1-32. Abstract. Author URL. Article has an altmetric score of 11 Terali K, Beavil RL, Pickersgill RW, van der Giezen M (2013). The effect of the adaptor protein Isd11 on the quaternary structure of the eukaryotic cysteine desulphurase Nfs1. Biochem Biophys Res Commun, 440(2), 235-240. Abstract. Author URL. Article has an altmetric score of 1 Müller M, Mentel M, van Hellemond JJ, Henze K, Woehle C, Gould SB, Yu RY, van der Giezen M, Tielens AG, Martin WF, et al (2012). Biochemistry and evolution of anaerobic energy metabolism in eukaryotes. Microbiol Mol Biol Rev, 76(2), 444-495. Abstract. Author URL. Article has an altmetric score of 29 Standley DM, van der Giezen M (2012). Modeling the alternative oxidase from the human pathogen Blastocystis using automated hybrid structural template assembly. Research and Reports in Biochemistry, 2, 1-8. Abstract. Author URL. Article has an altmetric score of 4 van der Giezen M, Lenton TM (2012). The rise of oxygen and complex life. Journal of Eukaryotic Microbiology, 59(2), 111-113. van der Giezen M (2011). Mitochondria and the Rise of Eukaryotes. BIOSCIENCE, 61(8), 594-601. Author URL. Article has an altmetric score of 2 Siegesmund MA, Hehl AB, van der Giezen M (2011). Mitosomes in trophozoites and cysts of the reptilian parasite Entamoeba invadens. Eukaryot Cell, 10(11), 1582-1585. Abstract. Author URL. Herman EK, Walker G, van der Giezen M, Dacks JB (2011). Multivesicular bodies in the enigmatic amoeboflagellate Breviata anathema and the evolution of ESCRT 0. Journal of Cell Science, 124, 613-621. Abstract. Griffith GW, Baker S, Fliegerova K, Liggenstoffer A, van der Giezen M, Voigt K, Beakes G (2010). Anaerobic fungi: Neocallimastigomycota. IAM Fungus, 1, 181-185. Author URL. Maralikova B, Ali V, Nakada-Tsukui K, Nozaki T, van der Giezen M, Henze K, Tovar J (2010). Bacterial-type oxygen detoxification and iron-sulfur cluster assembly in amoebal relict mitochondria. Cell Microbiol, 12(3), 331-342. Abstract. Author URL. Full text. Article has an altmetric score of 1 van der Giezen, M (2009). Hydrogenosomes and Mitosomes: Conservation and Evolution of Functions. J EUKARYOT MICROBIOL, 56(3), 221-231. Abstract. Article has an altmetric score of 6 van Grinsven KWA, Rosnowsky S, van Weelden SWH, Puetz S, van der Giezen M, Martin W, van Hellemond JJ, Tielens AGM, Henze K (2008). Acetate : succinate CoA-transferase in the hydrogenosomes of Trichomonas vaginalis - Identification and characterization. JOURNAL OF BIOLOGICAL CHEMISTRY, 283(3), 1411-1418. Author URL. Hamblin K, Standley DM, Rogers MB, Stechmann A, Roger AJ, Maytum R, van der Giezen M (2008). Localisation and nucleotide specificity of Blastocystis succinyl-CoA synthetase. Molecular Microbiology, 68, 1395-1405. Full text. Stechmann A, Hamblin K, Pérez-Brocal V, Gaston D, Richmond GS, van der Giezen M, Clark CG, Roger AJ (2008). Organelles in Blastocystis that blur the distinction between mitochondria and hydrogenosomes. Curr Biol, 18(8), 580-585. Abstract.