Titball, Richard - University of Exeter - Disciplines of Biosciences

个人简介

I am a bacteriologist with a strong interest in the molecular basis of bacterial pathogenicity. This information is exploited to devise improved vaccines and antibacterial therapies for disease in humans and animals. I am the academic leader of the Microbes and Disease research group and Head of Biosciences. Qualifications 2001 DSc Prophylaxis of disease caused by bacterial pathogens of man, University of Plymouth UK 1980-1983 PhD Microbiology, Plymouth Polytechnic UK 1976-1979 BSc Biological Sciences, Plymouth Polytechnic UK Career 2005: Society for General Microbiology Colworth Prize Lectureship 2004 Visiting Professor, University of Glasgow 2003 Elected Fellow of the Royal College of Pathologists 2003 Senior Research Fellow, Defence Science and Technology Laboratory Porton Down 2002 Visiting Professor of Bacterial Pathogenesis, University of Plymouth 2002 Honorary Professor, Department of Infectious and Tropical Diseases, London School of Hygiene and Tropical Medicine, University of London 1995 Individual Merit promotion to Grade 6 (IM) 1992 Head of Microbiology Department, Defence Science and Technology Laboratory Porton Down 1983 Post Doctoral Researcher, Defence Science and Technology Laboratory Porton Down 1983 PhD University of Plymouth 1979 University of Plymouth Biological Sciences prize

研究领域

Molecular Biology of bacterial pathogens of humans and animals, with a strong emphasis on research leading to vaccines against infectious disease. Previously lead research groups which have devised vaccines against plague and anthrax. These vaccines are currently in human clinical trials and should be licensed for use in humans within the next 2-3 years. Also devised vaccines against animal diseases caused by Clostridium perfringens; these vaccines are being developed by industry. Previously been involved in projects to sequence the genomes of Yersinia pestis (causes plague), Burkholderia pseudomallei (causes melioidosis), Francisella tularensis (causes tularaemia) and Clostridium perfringens (causes gas-gangrene). Research interests at University of Exeter 1. Understanding how the bacterium Burkholderia pseudomallei causes disease. B. pseudomallei, the causative agent of the disease melioidosis is an important human pathogen in Southeast Asia and northern Australia. The infection of humans with B. pseudomallei usually occurs via wounds or by the inhalation of organisms. The disease is especially problematic in diabetics. The clinical manifestations of melioidosis are not uniform and patients can present with pneumonia, skin abscesses, soft tissue abscesses or osteomyelitis / septic arthritis. Multi-drug resistance in B. pseudomallei is a significant problem in the treatment of melioidosis, so alternative countermeasures are needed. Furthermore there is no human vaccine currently licensed for protection against melioidosis. The work at Exeter will in the longer term lead to improved treatments for disease. 2. Understanding how the bacterium Clostridium perfringens causes disease. C. perfringens is the causative agent of food poisoning and gas-gangrene in man. Diabetics are especially predisposed to gas gangrene. C. perfringens also causes a range of diseases in domestic livestock such as sheep, lambs, piglets and calves. The ability of the bacterium to cause disease is due to the production of toxins. The work at Exeter will determine how these toxins function ata molecular level and in the longer term lead to improved treatments for disease. 3. Genetic predisposition to disease. This work is not yet fully established, but the aim is to understand why some individuals are more or less susceptible to disease caused by bacteria.

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Bokori-Brown M, Martin TG, Naylor CE, Basak AK, Titball RW, Savva CG (In Press). Cryo-EM Structure of Lysenin Pore Reveals Membrane Insertion by an Aerolysin family protein. Nature Communications Full text. Butt A, Halliday N, Williams P, Atkins HS, Bancroft GJ, Titball RW (2016). Burkholderia pseudomallei kynB plays a role in AQ production, biofilm formation, bacterial swarming and persistence. Research in Microbiology, 167(3), 159-167. Abstract. Article has an altmetric score of 2 Butt AT, Titball RW (2016). Functional Analysis of the Role of Toxin-Antitoxin (TA) Loci in Bacterial Persistence. Methods Mol Biol, 1333, 121-129. Abstract. Author URL. Full text. Champion OL, Gourlay LJ, Scott AE, Lassaux P, Conejero L, Perletti L, Hemsley C, Prior J, Bancroft G, Bolognesi M, et al (2016). Immunisation with proteins expressed during chronic murine melioidosis provides enhanced protection against disease. Vaccine, 34(14), 1665-1671. Abstract. Author URL. Full text. Article has an altmetric score of 57 Scott AE, Christ WJ, George AJ, Stokes MGM, Lohman GJS, Guo Y, Jones M, Titball RW, Atkins TP, Campbell AS, et al (2016). Protection against experimental melioidosis with a synthetic manno-heptopyranose hexasaccharide glycoconjugate. Bioconjugate Chemistry, 27(6), 1435-1446. Abstract. Bokori-Brown M, Petrov PG, Khafaji MA, Mughal MK, Naylor CE, Shore AC, Gooding KM, Casanova F, Mitchell TJ, Titball RW, et al (2016). Red Blood Cell Susceptibility to Pneumolysin: CORRELATION WITH MEMBRANE BIOCHEMICAL AND PHYSICAL PROPERTIES. J Biol Chem, 291(19), 10210-10227. Abstract. Author URL. Full text. Vanaporn M, Sarkar-Tyson M, Kovacs-Simon A, Ireland PM, Pumirat P, Korbsrisate S, Titball RW, Butt A (2016). Trehalase plays a role in macrophage colonization and virulence of Burkholderia pseudomallei in insect and mammalian hosts. Virulence, 1-11. Abstract. Article has an altmetric score of 1 Fernandes da Costa SP, Mot D, Geeraerts S, Bokori-Brown M, Van Immerseel F, Titball RW (2016). Variable protection against experimental broiler necrotic enteritis after immunization with the C-terminal fragment of Clostridium perfringens alpha-toxin and a non-toxic NetB variant. Avian Pathol, 45(3), 381-388. Abstract. Author URL. Gregory AE, Judy BM, Qazi O, Blumentritt CA, Brown KA, Shaw AM, Torres AG, Titball RW (2015). A gold nanoparticle-linked glycoconjugate vaccine against Burkholderia mallei. Nanomedicine, 11(2), 447-456. Abstract. Author URL. Nandi T, Holden MT, Didelot X, Mehershahi K, Boddey JA, Beacham I, Peak I, Harting J, Baybayan P, Guo Y, et al (2015). Burkholderia pseudomallei sequencing identifies genomic clades with distinct recombination, accessory, and epigenetic profiles. Genome Res, 25(4). Author URL. Full text. Nandi T, Holden MT, Didelot X, Mehershahi K, Boddey JA, Beacham I, Peak I, Harting J, Baybayan P, Guo Y, et al (2015). Burkholderia pseudomallei sequencing identifies genomic clades with distinct recombination, accessory, and epigenetic profiles. Genome Res, 25(1), 129-141. Abstract. Author URL. Article has an altmetric score of 12 Jewell SA, Titball RW, Huyet J, Naylor CE, Basak AK, Gologan P, Winlove CP, Petrov PG (2015). Clostridium perfringensα-toxin interaction with red cells and model membranes. Soft Matter, 11(39), 7748-7761. Abstract. Author URL. Full text. Siddiqui FM, Ibrahim M, Noureen N, Noreen Z, Titball RW, Champion OL, Wren BW, Studholme D, Bokhari H (2015). Draft Genome Sequence of the Enteropathogenic Bacterium Campylobacter jejuni Strain cj255. Genome Announc, 3(5). Abstract. Author URL. Full text. Article has an altmetric score of 3 Nandi T, Holden MTG, Didelot X, Mehershahi K, Boddey JA, Beacham I, Peak I, Harting J, Baybayan P, Guo Y, et al (2015). Errata: Burkholderia pseudomallei sequencing identifies genomic clades with distinct recombination, accessory, and epigenetic profiles (Genome Research (2015) 25 (129-141)). Genome Research, 25(4). Benthall G, Touzel RE, Hind CK, Titball RW, Sutton JM, Thomas RJ, Wand ME (2015). Evaluation of antibiotic efficacy against infections caused by planktonic or biofilm cultures of Pseudomonas aeruginosa and Klebsiella pneumoniae in Galleria mellonella. International Journal of Antimicrobial Agents, 46(5), 538-545. Abstract. Article has an altmetric score of 3 Gourlay LJ, Thomas RJ, Peri C, Conchillo-Solé O, Ferrer-Navarro M, Nithichanon A, Vila J, Daura X, Lertmemongkolchai G, Titball R, et al (2015). From crystal structure to in silico epitope discovery in the Burkholderia pseudomallei flagellar hook-associated protein FlgK. FEBS J, 282(7), 1319-1333. Abstract. Author URL. Rinchai D, Riyapa D, Buddhisa S, Utispan K, Titball RW, Stevens MP, Stevens JM, Ogawa M, Tanida I, Koike M, et al (2015). Macroautophagy is essential for killing of intracellular Burkholderia pseudomallei in human neutrophils. Autophagy, 11(5), 748-755. Abstract. Author URL. Full text. Article has an altmetric score of 1 Siddiqui F, Champion O, Akram M, Studholme D, Eqani SA, Wren BW, Titball R, Bokhari H (2015). Molecular detection identified a type six secretion system in Campylobacter jejuni from various sources but not from human cases. J Appl Microbiol, 118(5), 1191-1198. Abstract. Author URL. Torres AG, Gregory AE, Hatcher CL, Vinet-Oliphant H, Morici LA, Titball RW, Roy CJ (2015). Protection of non-human primates against glanders with a gold nanoparticle glycoconjugate vaccine. Vaccine, 33(5), 686-692. Abstract. Author URL. Gaudesi D, Peri C, Quilici G, Gori A, Ferrer-Navarro M, Conchillo-Solé O, Thomas R, Nithichanon A, Lertmemongkolchai G, Titball R, et al (2015). Structure-based design of a B cell antigen from B. pseudomallei. ACS Chem Biol, 10(3), 803-812. Abstract. Author URL.