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个人简介

教育经历 Education 1995-1999 南京农业大学,学士Bachelor’s degree, Nanjing Agricultural University, China 1999-2004 南京农业大学,昆虫学博士Ph.D. in Entomology, Nanjing Agricultural University, China 工作经历 Professional Experience 2004-2005 英国洛桑试验站 访问学者Visiting scholar, Rothamsted Research, UK 2005-2006 英国伦敦大学 博士后Postdoctoral fellow, University College London, UK 2006-present 南京农业大学 教授Professor, Nanjing Agricultural University, China 研究课题Project/主持项目 1. 2019 年 01 月至 2023 年 12 月,国家自然科学基金重点项目,稻飞虱对新烟碱类杀虫剂代谢抗性的遗传调控机制,31830075 2. 2020 年 01 月至 2023 年 12 月,国家自然科学基金面上项目,拟环纹豹蛛多肽毒素与醚菊酯共同调控昆虫钠离子通道的机制,31972296 3. 2018 年 01 月至 2021 年 12 月,国家自然科学基金面上项目,害虫天敌拟环纹豹蛛全部乙酰胆碱酯酶的特征与生理功能,31772185 4. 2014 年 01 月至 2016 年 12 月,国家自然科学基金优秀青年基金项目,昆虫神经毒理学,31322045 5. 2014 年 01 月至 2016 年 12 月,江苏省自然科学基金杰出青年基金项目,褐飞虱乙酰胆碱受体与杀虫剂的分子互作机制研究,BK20130028 主要荣誉 学术奖励/Awards and Honors 1. 2014 年 国家自然科学基金优秀青年基金获得者 2. 2014 年 江苏省自然科学基金杰出青年基金获得者 3. 2013 年 中组部万人计划-青年拔尖人才获得者 4. 2015 年 国家科技进步奖二等奖第 2 完成人,长江中下游稻飞虱暴发机制及可持续防控技术,2015-J-25101-2-03-R02 5. 2013 年 江苏省科学技术奖一等奖第 2 完成人,高产水稻飞虱的区域暴发机制与综合防控技术,2013-1-8-R2 6. 2007 年 全国优秀博士论文,褐飞虱对吡虫啉的抗性及其机理研究,2007049

研究领域

1、害虫(褐飞虱)抗药性机制研究Molecular mechanisms of insecticide resistancein agricultural pest insects 2、杀虫剂作用机制与选择性机制研究Mode of action of insecticides and theirselectivity 3、蜘蛛毒素类杀虫资源的开发与作用机制研究Predator spider genomics and peptide toxin

近期论文

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>60 publications with >1000 citations in journals including PNAS, J Neurochem., Insect Biochem Mol Biol., Pestic Biochem Physiol. List of some selected papers (Asterisk * indicates the corresponding author) 部分文章列表: (1) Bao, H., Gao, H., Zhang, J., Liu, Z.*, 2021. Neonicotinoids stimulate H2-limited methane emission in Periplaneta americana through the regulation of gut bacterium community. Environ Pollut. 285, 117237. (2) Gao, H., Lin, X., Yang, B., Liu, Z.*, 2021. The roles of GSTs in fipronil resistance in Nilaparvata lugens: Over-expression and expression induction. Pestic Biochem Physiol. 177,104880. (3) Wang, K., Zhang, F., Wei, Y.,… Liu, Z.*, Liu, S.*, 2021. In Situ imaging of cellular reactive oxygen species and Caspase-3 activity using a multifunctional theranostic probe for cancer diagnosis and therapy. Anal Chem. 93(22), 7870-7878. (4) Yang, Z., Yu, N., Wang, S., Korai, S.K., Liu, Z.*, 2021. Characterization of ecdysteroid biosynthesis in the pond wolf spider, Pardosa pseudoannulata. Insect Mol Biol., 30(1), 71-80. (5) Yu, N, Han, C, Liu, Z.*, 2020. In silico identification of the neuropeptidome of the pond wolf spider Pardosa pseudoannulata. Gen Comp Endocrinol, 285, 113271. (6) Zhang, Y., Xu, X., Bao, H., Shao, X., Li, Z., Liu, Z.*, 2019. The binding properties of cycloxaprid on insect native nAChRs partially explain the low cross-resistance with imidacloprid in Nilaparvata lugens. Pest Manage Sci, 75 (1), 246-251. (7) Yu, N., Wang, X., Bao, H., Liu, Z.*, 2019. Identification and functional study of three nAChR regulators, ubiquilin-1, PICK1, and CRELD2, in Locusta migratoria manilensis dorsal unpaired median neurons. J Neurochem, 149(3), 331-345. (8) Huang, L., Wang, Z., Yu, N., Li, J., Liu, Z.*, 2018. Toxin diversity revealed by the venom gland transcriptome of Pardosa pseudoannulata, a natural enemy of several insect pests. Comp Biochem Physiol Part D Genomics Proteomics, 28 172-182. (9) Yu, N., Tian, J., Zhang, Y., Li, Z., Liu, Z.*, 2018. Imidacloprid-susceptible Nilaparvata lugens individuals exceeded resistant individuals in a mixture population with density pressure. Pest Manag Sci. 74, 234-239. (10) Sun, H., Yang, B., Zhang, Y., Liu, Z.*, 2017. Metabolic resistance in Nilaparvata lugens to etofenprox, a non-ester pyrethroid insecticide. Pestic. Biochem. Physiol. 136, 23-28. (11) Bao, H., Meng, X., Liu, Z.*, 2017. Spider acetylcholine binding proteins: An alternative model to study the interaction between insect nAChRs and neonicotinoids. Insect Biochem Mol Biol. 90, 82-89. (12) Zhang, Y., Yang, Y., Sun, H., Liu, Z.*, 2016. Metabolic imidacloprid resistance in the brown planthopper, Nilaparvata lugens, relies on multiple P450 enzymes. Insect Biochem Mol Biol 79, 50-56. (13) Zhang, Y., Wang, X., Yang, B., Hu, Y., Huang, L., Bass, C., Liu Z.*, 2015. Reduction in mRNA and protein expression of a nicotinic acetylcholine receptor α8 subunit is associated with resistance to imidacloprid in the brown planthopper, Nilaparvata lugens. J Neurochem. 135, 686-694. (14) Zhang, Y., Shao, Y., Jiang, F., Li, J., Liu, Z.*, 2014. Identification of two acetylcholinesterases in Pardosa pseudoannulata and the sensitivity to insecticides. Insect Biochem. Mol. Biol. 46, 25-30. (15) Ding, Z., Wen, Y., Yang, B., Zhang, Y., Liu, S., Liu, Z.*, 2013. Biochemical mechanisms of imidacloprid resistance in Nilaparvata lugens: Over-expression of cytochrome P450 CYP6AY1. Insect Biochem Mol Biol. 43, 1021-1027.Liu, Z., Han, Z., Wang, Y., Zhang, L., Zhang, H., Liu, C., 2003. Selection for imidacloprid resistance in Nilaparvata lugens: cross-resistance patterns and possible mechanisms. Pest Manag. Sci. 59, 1355-1359. (16) Shao, X., Lu, H., Bao, H., Xu, X., Liu, Z.*, Li, Z., 2011. The mode of action of a nitroconjugated neonicotinoid and the effects of target site mutation Y151S on its potency. Insect Biochem. Mol. Biol. 41, 440-445. (17) Liu, Z.*, Han, Z., Liu, S., Zhang, Y., Song, F., Yao, X., Gu, J., 2008. Amino acids outside of the loops that define the agonist binding site are important for ligand binding to insect nicotinic acetylcholine receptors. J. Neurochem. 106, 224-230. (18) Liu, Z., Han, Z., 2006. Fitness costs of laboratory-selected imidacloprid resistance in the brown planthopper, Nilaparvata lugens Stål, Pest. Manag. Sci. 62, 279-282. (19) Liu, Z., Williamson, M.S., Lansdell, S.J., Han, Z., Denholm, I., Millar, N.S., 2006. A nicotinic acetylcholine receptor mutation (Y151S) causes reduced agonist potency to a range of neonicotinoid insecticides. J. Neurochem. 99, 1273-1281. (20) Liu, Z., Williamson, M.S., Lansdell, S.J., Denholm, I., Han, Z., Millar, N.S., 2005. A nicotinic acetylcholine receptor mutation conferring target-site resistance to imidacloprid in Nilaparvata lugens (brown planthopper). Proc Natl Acad Sci U S A. 102, 8420-8425.

学术兼职

1. 2017.10-2022.10 中国昆虫学会理事Council member, the Entomological Society of China; 2. 2015.01-2019.12 《昆虫学报》编委Editorial board member, Acta Entomologica Sinica; 3. 2012.09-2016.12 江苏省昆虫学会常务理事Council member, the Entomological Society of Jiangsu

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