个人简介
段亚冰,男,农业农村部第九届全国农药登记评审委员会委员,江苏省“科技副总”,江苏省农药生产许可审查专家,农业农村部农药登记试验认证单位-南京农业大学植物保护应用技术中心杀菌剂技术负责人,中国农药发展与应用协会杀菌剂专业委员会秘书。主要从事杀菌剂毒理与抗药性研究,主要成果如下:揭示重要农作物病原菌对主流杀菌剂的抗性分子机制,探明重要农作物病原菌药靶基因的抗药性优势突变基因型,发现1个杀菌剂选择性新靶标;探明井冈霉素、呼吸抑制剂、多菌灵及其抗性调控赤霉病菌毒素生物合成的药理学机制,阐明杀菌剂药靶CYP51s和β微管蛋白参与调控赤霉病菌产毒小体结构形成的理论基础,发现赤霉病菌产毒小体在次生代谢调控中的新功能;首创LAMP抗药性快速检测技术,写入高校教材,实现公益性推广;研发系列抗性治理技术,实现产业化应用。以第一或通讯作者在Mol.PlantPathol.,PestManag.Sci.,J.PestSci.,J.Hazard.Mater.等学科TOP期刊上发表SCI论文70余篇,近5年论文被引近1500次,单篇论文最高被引频次百余次。获得授权国家发明专利30余项,其中美、英、澳、加、日等国际发明专利8项,成果转化1项;主持或参与国家自然科学基金、国家重大基础研发计划、国家重点研发计划项目等项目30余项。以主要完成人获得国家科技进步二等奖1项,省部级奖励6项。
工作经历:
2020.12-至今南京农业大学植物保护学院农药系,教授
2017.10-2018.10英国洛桑农业研究所(RothamstedResearch),访问学者
2015.12-2020.12南京农业大学植物保护学院农药系,副教授,硕士生导师
2013.09-2015.12南京农业大学植物保护学院农药系,讲师
执教课程:
本科生:《植物保护学通论》、《植物化学保护》、《农药制剂学》、《农药与生活》
研究生:《农药生物学》、《农药抗性与治理》
承担课题:
1.江苏省农业科技自主创新资金项目,设施农业重大病害抗药性检测与治理技术研发,CX(19)3110,2019.07-2021.06,主持
2.国家自然科学基金-面上项目,甲氧基丙烯酸酯类杀菌剂对亚洲镰孢菌DON毒素生物合成的分子调控机制,31772190,2018.01-2021.12,主持
3.国家重点研发计划,经济作物化学农药协同增效技术与产品研发,2016YFD0200504-01,2016.01-2020.12,子课题主持
4.国家重点研发计划,化学农药协同增效关键技术及产品研发,2016YFD0200501-04,2016.01-2020.12,项目骨干
5.国家重点研发计划,粮食作物化学农药协同增效技术与产品研发,2016YFD0200503-04,2016.01-2020.12,项目骨干
6.国家重点研发计划,江淮稻-麦种植区主要病虫草害的绿色防控技术,2016YFD0300706,2016.01-2020.12,项目骨干
7.国家重点研发计划,油菜菌核病抗药性治理药剂筛选及农药减施技术研发,2018YFD0200905-9,2018.1-2020.12,项目骨干
8.国家自然科学基金-青年基金,苯吡咯类杀菌剂咯菌腈对油菜菌核病菌双组份信号传导系统的调控机制研究,31401764,2015.01-2017.12,主持
9.中央高校基本业务费,苯吡咯类杀菌剂咯菌腈对油菜菌核病菌双组分信号系统的调控机制研究,KJQN201508,2015.01-2017.12,主持
10.江苏省农业科技自主创新资金,稻穗期病害病原菌抗药性监测预警与绿色新农药研发,CX(15)1054,2015.06-2017.12,子课题主持
11.江苏省自然科学基金,核盘菌响应调控因子RRG-1和RRG-2对PPFs和DCFs的药敏性调控机制研究,BK20140679,2014.07-2017.06,主持
12.江苏省科技支撑计划,小麦赤霉病流行预警及生物-化学协同防控技术研发,BE2013432,2013.7-2016.6,项目骨干
13.国家重大基础研发计划“973”,小麦赤霉病无公害药物新靶标的功能及其与药剂分子互作机制,2012CB114002,2012.01-2016.12,子课题主持
14.国家公益性行业(农业)科研行业专项,油菜作物菌核病综合防控技术研究与示范推广,201103016,2011.1-2015.12,项目骨干代表性科研成果:发表SCI论文70余篇,授权国家发明专利30余项,其中美、英、澳、加、日等国际授权发明专利7项。
近5年代表性授权发明专利:
[1]段亚冰,周明国,杨莹,张晓柯,王建新,一种快速鉴定灰葡萄孢菌对多菌灵抗性基因型F200Y菌株的分子检测方法,授权时间:20160511,中国,ZL201410646783.0
[2]段亚冰,周明国,杨莹,张晓柯,王建新,曹君红,一种基于LAMP技术对多菌灵高抗灰葡萄孢菌株的快速检测方法,授权时间:20160817,中国,ZL201410619316.9
[3]周明国,段亚冰,王建新,一种用于防治麦类赤霉病的含叶菌唑农药组合物及其用途,授权时间:20170524,中国,ZL201510801884.5
[4]周明国,段亚冰,王建新,一种用于防治麦类赤霉病的含戊唑醇农药组合物及其用途,授权时间:20170630,中国,ZL201510807440.2
[5]周明国,王建新,段亚冰,蔡义强,李雁军,一种增效减量农药组合物在防治麦类赤霉病中的用途,授权时间:20171114,中国,ZL201610036814.X
[6]周明国,段亚冰,一种防治小麦赤霉病的复配杀菌剂及其应用,授权时间:20171121,中国,ZL201610102918.6
[7]周明国,段亚冰,王建新,一种用于防治麦类赤霉病的含三唑酮农药组合物及其用途,授权时间:20171128,中国,ZL201510800325.2
[8]段亚冰,周明国,陈长军,杨莹,王建新,张晓柯,一种快速检测灰葡萄孢菌对QoI类杀菌剂抗性的方法及引物组合物,授权时间:20171212,中国,ZL201510570028.3
[9]周明国,段亚冰,王建新,侯毅平,杨莹,一种含有氰烯菌酯和种菌唑的农药组合物在防治水稻恶苗病中的用途,授权时间:20171226,中国,ZL201610190544.8
[10]段亚冰,周明国,陈长军,杨莹,王建新,张晓柯,一种快速检测灰葡萄孢菌对SDHI类杀菌剂抗性的方法及引物组合物,授权时间:20171205,中国,ZL201510450026.0
[11]周明国,王建新,段亚冰,蔡义强,李雁军,一种农药组合物在防治麦类赤霉病中的用途,授权时间:20180410,中国,ZL201610036748.6
[12]周明国,段亚冰,王建新,侯毅平,杨莹,一种井冈霉素和种菌唑的杀菌组合物及其应用,授权时间:20180330,中国,ZL201610316497.7
[13]周明国,段亚冰,王建新,杨莹,武健,一种井冈霉素和灭菌唑的杀菌组合物及其应用,授权时间:20181030,中国,ZL201610589617.0
[14]周明国,段亚冰,杨莹,武健,一种含种菌唑和福美双的杀菌组合物及其应用,授权时间:20190322,中国,ZL201610589616.6
[15]周明国,段亚冰,王建新,侯毅平,周泽华,李美霞,氰基丙烯酸酯类化合物在制备治疗人畜真菌性感染疾病的药物中的应用,授权时间:20190820,中国,ZL201710338081.X,
[16]周明国,段亚冰,李美霞,武健,李涛,赵东磊,一种含叶菌唑的协同减量杀菌组合物,授权时间:20191112,中国,ZL201710387750.2,
[17]周明国,段亚冰,宋修仕,王建新,武健,一种含啶菌恶唑与氯啶菌酯的杀菌组合物及其应用,授权时间:20210821,中国,ZL2018108857463,
[18]MingguoZhou,YabingDuan,JianxinWang,Metconazole-containingpesticidecompositionforpreventingandcontrollingfusariumheadblightandapplicationthereof,20180424,US9949479.(美国发明专利)
[19]MingguoZhou,YabingDuan,JianxinWang,Metconazole-containingpesticidecompositionforpreventingandcontrollingfusariumheadblightandapplicationthereof,20180927,AU2016356037.(澳大利亚发明专利)
[20]MingguoZhou,YabingDuan,JianxinWang,Tebuconazole-containingpesticidecompositionforcontrollingfusariumheadblightandapplicationthereof,20181107,GB2554017.(英国发明专利)
[21]MingguoZhou,YabingDuan,JianxinWang,Tebuconazole-containingpesticidecompositionforcontrollingfusariumheadblightandapplicationthereof,20200317,US10588316.(美国发明专利)
[22]MingguoZhou,YabingDuan,JianxinWang,Metconazole-containingpesticidecompositionforpreventingandcontrollingfusariumheadblightandapplicationthereof,20190625,CA2977418.(加拿大发明专利)
[23]MingguoZhou,YabingDuan,JianxinWang,ApesticidecompositioncontainingJinggangmycinandipconazoleanditsapplificationthereof,20200615,6717980.(日本发明专利)
[24]MingguoZhou,YabingDuan,JianxinWang,Apesticidecompositioncomprisingtebuconazoleandjinggangmycinforpreventingandcontrollingfusariumheadblight,andamethodwhereinthepesticidecompositionisappliedtocultivatedgraincrops,20200324,CA2985520.(加拿大发明专利)
荣誉奖励:
江苏省科技进步二等奖,《果蔬作物灰霉病菌和菌核病菌抗药性及治理关键技术》,第二名,2020年
南京农业大学“超大”奖教金,独立完成人,2020年
中国产学研合作创新与促进奖-产学研合作创新成果一等奖,第二名,2021年
山东省科技进步三等奖,《蔬菜重要病害鉴定检测与精准防控技术研究与应用》,第二名,2019年
国家科技进步二等奖,《杀菌剂氰烯菌酯新靶标的发现及产业化应用》,第七名,2018年
教育部科技进步一等奖,《氰烯菌酯杀菌剂新靶标的发现及产业化应用》,第八名,2017年
河南省科技进步三等奖,《设施蔬菜灰霉病抗药性分子检测及精准防控关键技术研究与应用》,第三名,2017年高被引论文,Elservier出版集团,2016年
其他:热烈欢迎对杀菌剂生物学研究领域有兴趣的有志人士加盟团队。
近期论文
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[1]XiuQian,BiLianyu,XuHaorong,LiTao,ZhouZehua,LiZhongke,WangJianxin,DuanYabing*,ZhouMingguo*.AntifungalactivityofquinofumelinagainstFusariumgraminearumanditsinhibitoryeffectondonbiosynthesis.Toxins.2021,13,348.[2]BianChuanhong,DuanYabing*,XiuQian,WangJueyu,TaoXian,ZhouMingguo*.MechanismofvalidamycinainhibitingdonbiosynthesisandsynergizingwithDMIfungicidesagainstFusariumgraminearum.MolecularPlantPathology.2021,22,769-785.[3]LiTao,XiuQian,WangQiao,WangJianxin,DuanYabing*,ZhouMingguo*.(2021).FunctionaldissectionofindividualdomainsingroupiiihistidinekinaseSshk1pfromthephytopathogenicfungusSclerotiniasclerotiorum.PesticideBiochemistryandPhysiology.2021,178:104914.[4]ZhouZehua,ZhangJie,LuFei,DuanYabing,ZhouMingguo*.Glucose-6-phosphateisomeraseFgGPI,aβ2tubulin-interactingprotein,isindispensableforfungaldevelopmentanddeoxynivalenolbiosynthesisinFusariumgraminearum.Phytopathology,2021,doi.org/10.1094/PHYTO-07-20-0279-R.[5]TaoXian,ZhaoHuahua,XuHaorong,LiZhongke,WangJianxin,SongXiushi,ZhouMingguo,DuanYabing*.AntifungalactivityandbiologicalcharacteristicsofthenovelfungicidequinofumelinagainstSclerotiniasclerotiorum.PlantDisease,2021,doi.org/10.1094/PDIS-08-20-1821-RE.[6]LiTao,XiuQian,WangJianxin,DuanYabing*,ZhouMingguo*.AputativeMAPKkinasekinasegeneSsos4isinvolvedinmycelialgrowth,virulence,osmoticadaptation,andsensitivitytofludioxonilandisessentialforSsHog1phosphorylationinSclerotiniasclerotiorum.Phytopathology,2021,111:521-530.[7]ZhouZehua,DuanYabing,ZhangJie,LeFei,ZhuYuanye,ShimWonBo,ZhouMingguo*.Microtubule-assistedmechanismfortoxisomeassemblyinFusariumgraminearum.MolecularPlantPathology,2021,22:163-174.[8]KevinM.King,DianaE.Bucur,FayeRitchie,NicholaJ.Hawkins,AgataM.Kaczmarek,YabingDuan,StevenKildea,JonathanS.West,BartA.Fraaije.FungicideresistancestatusandchemicalcontroloptionsforthebrassicapathogenPyrenopezizabrassicae.PlantPathology.2021,https://doi.org/10.1111/ppa.13441[9]DuanYabing,LuFei,ZhouZehua,ZhaoHuahua,ZhangJie,MaoYushuai,LiMeixia,WangJianxin,ZhouMingguo*.QuinoneoutsideinhibitorsaffectDON
biosynthesis,mitochondrialstructureandtoxisomeformationinFusariumgraminearum.JournalofHazardousMaterials,2020,398:122908.[10]BianChuanhong,DuanYabing,WangJueyu,XiuQian,WangJianxin,HouYiping,SongXiushi,ZhouMingguo*.ValidamycinAinducesbroad-spectrumresistanceinvolvingsalicylicacidandjasmonicacid/ethylenesignalingpathways.MolecularPlant-MicrobeInteractions,2020,33:1424-1437.[11]LiTao,XiuQian,ZhangJie,WangJianxin,DuanYabing*,ZhouMingguo*.PharmacologicalcharacteristicsandefficacyoffluazinamagainstCorynesporacassiicola,causingcucumbertargetspotingreenhouses.PlantDisease,2020,104:2449-2454.[12]ZhouZehua,DuanYabing,ZhouMingguo*.Carbendazim‐resistanceassociatedβ2‐tubulinsubstitutionsincreasedeoxynivalenolbiosynthesisbyreducingtheinteractionbetweenβ2‐tubulinandIDH3inFusariumgraminearum.EnvironmentalMicrobiology,2020,22:598-614.[13]XinWenjing,MaoYushuai,LiTao,WangJianxin,DuanYabing*,ZhouMingguo*.InvitrofungicidalactivityandinplantacontrolefficacyofcoumoxystrobinagainstMagnaportheoryzae.PesticideBiochemistryandPhysiology,2020,162:78-85.[14]MaoYushuai,ZhangYong,ZhouMingguo,DuanYabing*.OccurrenceofcrownrotdiseasecausedbyFusariumincarnatumoncucumber(Cucumissativus)inChina.PlantDisease,2020,104:593.[15]WuJian,PanXiayan,XuShu,DuanYabing,WangJueyu,WangJianxin,GaoTongchun,ZhangYong*,ZhouMingguo*.Adefectinthetwin-argininetranslocation(TAT)pathwaydecreasesthetoleranceofXanthomonascampestrispv.campestristophenazines.Phytopathology,2020,110:1897-1907.[16]XuChao,LiMeixa,ZhouZehua,LiJiaosheng,ChenDongming,DuanYabing*,ZhouMingguo*.ImpactoffivesuccinatedehydrogenaseinhibitorsonDONbiosynthesisofFusariumasiaticum,causingFusariumheadblightinwheat.Toxins,2019,11:272.[17]LiYanjun,ChenDongming,LuoShunwen,ZhuYuanye,JiaXiaojing,DuanYabing,ZhouMingguo.Intron-mediatedregulationofβ-tubulingenesexpressionaffectsthesensitivitytocarbendaziminFusariumgraminearum.CurrentGenetics,2019,65:1057-1069.[18]WuJian,PanXiayan,XuShu,DuanYabing,LuoJianying,ZhouZehua,WangJianxin,ZhouMingguo*.Thecriticalroleofcytochromecmaturation(CCM)systeminthetoleranceofXanthomonascampestrispv.campestristophenazines.PesticideBiochemistryandPhysiology,2019,156:63-71.[19]DuanYabing,TaoXian,ZhaoHuahua,XiaoXuemei,LiMeixia,WangJianxin,ZhouMingguo*.ActivityofdemethylationinhibitorfungicidemetconazoleonChineseFusariumgraminearumspeciescomplexanditsapplicationincarbendazim-resistancemanagementofFusariumheadblightinwheat.PlantDisease,2019,103:929-937.[20]DuanYabing,XiuQian,LiHaoran,LiTao,WangJianxin,ZhouMingguo*.
PharmacologicalcharacteristicsandcontrolefficacyofanovelSDHIfungicidepydiflumetofenagainstSclerotiniasclerotiorum.PlantDisease,2019,103:77-82.[21]LiJing,DuanYabing,BianChuanhong,PanXiayan,YaoChengjie,WangJianxin,ZhouMingguo*.EffectsofvalidamycinincontrollingFusariumheadblightcausedbyFusariumgraminearum:InhibitionofDONbiosynthesisandinductionofhostresistance,PesticideBiochemistryandPhysiology,2019,153:152-160.[22]DuanYabing,XinWenjing,LuFei,LiTao,LiMeixia,WuJian,WangJianxin,ZhouMingguo*.Benzimidazole-andQoI-resistanceinCorynesporacassiicolapopulationsfromgreenhouse-cultivatedcucumber:AnemergingprobleminChina.PesticideBiochemistryandPhysiology,2019,153:95-105.[23]DuanYabing,LiMeixia,ZhaoHuahua,LuFei,WangJianxin,ZhouMingguo*.Molecularandbiologicalcharacteristicsoflaboratorymetconazole-resistantmutantsinFusariumgraminearum.PesticideBiochemistryandPhysiology,2018,152:55-61.[24]DuanYabing,XiaoXuemei,LiTao,ChenWeiwei,WangJianxin,FraaijeBartA.ZhouMingguo*.ImpactofepoxiconazoleonFusariumheadblightcontrol,grainyieldanddeoxynivalenolaccumulationinwheatPesticideBiochemistryandPhysiology,2018,152:138-147.[25]PanXiayan,WuJian,XuShu,DuanTingting,DuanYabing,WangJianxin,ZhangFeng*,ZhouMingguo*.ContributionofOxyRtowardsdifferentialsensitivitytoantioxidantsinXanthomonasoryzaepathovarsoryzaeandoryzicola.MolecularPlant-MicrobeInteractions,2018,31:1244-1256.[26]DuanYabing,LiTao,XiaoXuemei,WuJian,LiShengkun,WangJianxin,ZhouMingguo*.PharmacologicalcharacteristicsofthenovelfungicidepyrisoxazoleagainstSclerotiniasclerotiorum.PesticideBiochemistryandPhysiology,2018,149:61-66.[27]DuanYabing,YangYing,WangJianxin,ChenChangjun,SteinbergGero,FraaijeBart,ZhouMingguo*.Simultaneousdetectionofmultiplebenzimidazoleresistantβ-tubulinvariantsofBotrytiscinereausingloopmediatedisothermalamplification.PlantDisease.2018,102:2016-2024.[28]DuanYabing,YangYing,LiMeixia,LiTao,FraaijeBart,ZhouMingguo*.Developmentandapplicationofasimple,rapidandsensitivemethodfordetectingmoderatelycarbendazim‐resistantisolatesinBotrytiscinerea.AnnalsofAppliedBiology,2018,172:355-365.[29]LiMeixia,LiTao,DuanYabing*,YangYing,WuJian,ZhaoDonglei,WangJianxin,ZhouMingguo*.Evaluationofphenamacrilandipconazoleforcontrolofricebakanaediseasecausedbyfusariumfujikuroi.PlantDisease,2018,102:1234-1239.[30]YangYing,LiMeixia,DuanYabing*,LiTao,ShiYiyuan,ZhaoDonglei,ZhouZehua,XinWenjing,WuJian,PanXiayan,LiYanjun,ZhuYuanye,ZhouMingguo*.Anewpointmutationinβ2-tubulinconfersresistancetocarbendaziminFusariumasiaticum.PesticideBiochemistryandPhysiology,2018,145:15-21.
[31]PanXiayan,XuShu,WuJian,LuoJianying,DuanYabing,WangJian,ZhouMingguo*.ScreeningandcharacterizationofXanthomonasoryzaepv.oryzaestrainswithresistancetopheazine-1-carboxylicacid.PesticideBiochemistryandPhysiology,2018,145:8-14.[32]LiangXiaoyu,YuXiaoyue,PanXiayan,WuJian,DuanYabing,WangJianxin,ZhouMingguo*.AthiadiazolereducesthevirulenceofXanthomonasoryzaepv.oryzaebyinhibitingthehistidineutilizationpathwayandquorumsensing.MolecularPlantPathology,2018,19:116-128.