Shaw, Andrew - University of Exeter - Disciplines of Biosciences

个人简介

1989-1992 PhD Physical Chemistry, University of Southampton 1985-1988, 1992 MA Natural Sciences, University of Cambridge Career 2007 – Present, Associate Professor of Physical Chemistry 2007 – Present, Founder and Director of Attomarker Ltd 2009 – Present, Chairman of Arkiris, KTA 2005-2007 Senior Lecturer in Physical Chemistry, University of Exeter 2005-present Senior Lecturer in Physical Chemistry, School of Biosciences, University of Exeter 2001-2005 Lecturer in Physical Chemistry, Department of Chemistry, University of Exeter 2002-present Founder and Director of Research, EvanesCo Ltd 1999-2001 Postdoctoral Research Fellow, Stanford University 1992-1999 University Research Fellow, University of Southampton 1999 Fellow of the Royal Astronomical Society 1994 Member of the Royal Society of Chemistry

研究领域

My research uses the principles of physical chemistry to make measurements on systems in Chemical Biology. We are currently developing a screening technology that will allow the concentrations of molecules in blood to be measured that may act as biomarkers of disease and extend the field of differential diagnosis. My research concentrates on the fundamental the quantitative description of measurements interpreted with a mathematical model. The research directions have led to the formation of a company to exploit the technology commercially with application in the petrochemical industry, production quality monitoring and Homeland Security. Teaching interests in the School are Physical Chemistry for the Life Sciences, Astrochemistry and Astrobiology and Forensic Science. All modules explore the quantitative interpretation of physical processes. I have written a textbook Astrochemistry: From Astronomy to Astrobiology, published by Wiley in 2006. In addition to my teaching duties I am also Study Abroad Tutor for our international exchange programme. I am a member of the Molecules and cells research group.

近期论文

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Gregory AE, Judy BM, Qazi O, Blumentritt CA, Brown KA, Shaw AM, Torres AG, Titball RW (2015). A gold nanoparticle-linked glycoconjugate vaccine against Burkholderia mallei. Nanomedicine, 11(2), 447-456. Abstract. Author URL. Read T, Olkhov RV, Williamson ED, Shaw AM (2015). Kinetic epitope mapping of monoclonal antibodies raised against the Yersinia pestis virulence factor LcrV. Biosensors and Bioelectronics, 65, 47-53. Abstract. Read T, Olkhov RV, Williamson ED, Shaw AM (2015). Label-free Fab and Fc affinity/avidity profiling of the antibody complex half-life for polyclonal and monoclonal efficacy screening. Analytical and Bioanalytical Chemistry Abstract. Full text. Article has an altmetric score of 1 Morad HOJ, Belete SC, Read T, Shaw AM (2015). Time-course analysis of C3a and C5a quantifies the coupling between the upper and terminal Complement pathways in vitro. JOURNAL OF IMMUNOLOGICAL METHODS, 427, 13-18. Author URL. Article has an altmetric score of 2 McQuillan JS, Shaw AM (2014). Differential gene regulation in the Ag nanoparticle and Ag(+)-induced silver stress response in Escherichia coli: a full transcriptomic profile. Nanotoxicology, 8 Suppl 1, 177-184. Abstract. Author URL. Article has an altmetric score of 1 van Vuuren BJ, Bergseth G, Mollnes TE, Shaw AM (2014). Electroluminescent TCC, C3dg and fB/Bb epitope assays for profiling complement cascade activation in vitro using an activated complement serum calibration standard. J Immunol Methods, 402(1-2), 50-56. Abstract. Author URL. Full text. van Vuuren BJ, Bergseth G, Mollnes TE, Shaw AM (2014). Electroluminescent TCC, C3dg and fB/Bb epitope assays for profiling complement cascade activation in vitro using an activated complement serum calibration standard. Journal of immunological methods, 402(1-2), 50-56. Abstract. Olkhov RV, Weissenborn MJ, Flitsch SL, Shaw AM (2014). Glycosylation characterization of human and porcine fibrinogen proteins by lectin-binding biophotonic microarray imaging. Anal Chem, 86(1), 621-628. Abstract. Author URL. Full text. Article has an altmetric score of 1 Olkhov RV, Shaw AM (2014). Growth kinetics of gold nanoparticles on silica/graphene surfaces for multiplex biological immunoassays. RSC Advances, 4(60), 31678-31684. Abstract. Full text. Penwill LA, Batten GE, Castagnetti S, Shaw AM (2014). Growth phenotype screening of Schizosaccharomyces pombe using a Lensless microscope. Biosens Bioelectron, 54, 345-350. Abstract. Author URL. Full text. Mcquillan JS, Shaw AM (2014). Whole-cell Escherichia coli-based bio-sensor assay for dual zinc oxide nanoparticle toxicity mechanisms. Biosens Bioelectron, 51, 274-279. Abstract. Author URL. Full text. Read T, Olkhov RV, Shaw AM (2013). Measurement of the localised plasmon penetration depth for gold nanoparticles using a non-invasive bio-stacking method. Phys Chem Chem Phys, 15(16), 6122-6127. Abstract. Author URL. Full text. Walker NDL, Olkhov RV, Shaw AM (2013). pH-dependent electronic surface spectra of chromophore species in the charged silica-water interface. RSC ADVANCES, 3(27), 10927-10933. Author URL. Gregory AE, Shaw AM, Titball RW, Williamson ED, Prior JL, Butcher WA, Thompson IJ (2012). Conjugation of Y. pestis F1-antigen to gold nanoparticles improves immunogenicity. Vaccine Abstract. Gregory AE, Williamson ED, Prior JL, Butcher WA, Thompson IJ, Shaw AM, Titball RW (2012). Conjugation of Y. pestis F1-antigen to gold nanoparticles improves immunogenicity. Vaccine, 30(48), 6777-6782. Abstract. Author URL. Full text. Heuts DP, Weissenborn MJ, Olkhov RV, Shaw AM, Gummadova J, Levy C, Scrutton NS (2012). Crystal structure of a soluble form of human CD73 with ecto-5'-nucleotidase activity. Chembiochem, 13(16), 2384-2391. Abstract. Author URL. Article has an altmetric score of 5 Olkhov RV, Kaminski ER, Shaw AM (2012). Differential immuno-kinetic assays of allergen-specific binding for peanut allergy serum analysis. Analytical and Bioanalytical Chemistry, 404(8), 2241-2247. Abstract. Olkhov RV, Kaminski ER, Shaw AM (2012). Differential immuno-kinetic assays of allergen-specific binding for peanut allergy serum analysis. Anal Bioanal Chem, 404(8), 2241-2247. Abstract. Author URL. Full text. McQuillan JS, Infante HG, Stokes E, Shaw AM (2012). Silver nanoparticle enhanced silver ion stress response in Escherichia coli K12. Nanotoxicology, 6, 857-866. Abstract. Author URL. Olkhov RV, Parker R, Shaw AM (2012). Whole blood screening of antibodies using label-free nanoparticle biophotonic array platform. Biosensors and Bioelectronics, 36(1), 1-5. Abstract.