Schrader, Michael - University of Exeter - Disciplines of Biosciences

个人简介

I am a molecular cell biologist interested in the biogenesis and dynamics of cellular compartments (organelles) in mammalian cells. My research focuses on the molecular machinery and signalling pathways, which mediate and regulate the formation, dynamics and abundance of peroxisomes. Our goal is to understand the relation of organelle dynamics to organelle functionality and its impact on developmental and physiological processes. My teaching includes molecular cell biology and biomedical aspects. I am a member of the Cell Biology research group. Qualifications 1996 PhD Cell Biology, University of Heidelberg, Germany 1991 Diploma in Biology, University of Bielefeld, Germany Career 2012-present Associate Professor of Cell Biology, School of Biosciences, University of Exeter, UK 2007-2011 Head of research group at the Centre for Cell Biology & Dept. of Biology, University of Aveiro, Portugal 2002 Habilitation, Venia Legendi in Cell Biology, University of Marburg, Germany 2001-2006 Hochschulassistent (=Assistant Professor), Privatdozent (PD) and Group leader at the Dept. of Cell Biology and Cell Pathology, University of Marburg, Germany 1999-2000 Postdoctoral Research Fellow with H. F. Kern, University of Marburg, Germany 1997-1998 Postdoctoral Research Fellow with T. A. Schroer, Johns Hopkins University, Baltimore, MD, USA 1992-1996 PhD in Cell Biology (Laboratory of H. D. Fahimi), University of Heidelberg, Germany 1986-1991 Diploma in Biology, University of Bielefeld, Germany

研究领域

During my research career my interests have been focused on the molecular mechanisms associated with organelle dynamics and biogenesis in mammalian cells and their relation to inter-organellar communication and cell physiology. Our model organelle, among others, is the peroxisome. Peroxisomes contribute to several disease-relevant metabolic pathways in mammals (e.g., hydrogen peroxide metabolism, generation and scavenging of reactive oxygen species, break-down of fatty acids by beta-oxidation, and synthesis of ether phospholipids, which are important constituents of myelin sheaths) and have been associated with developmental processes, oxidative stress, ageing and neurodegeneration. In mammalian cells peroxisomes can easily be visualized by peroxisome-targeted fluorescent fusion proteins. Peroxisomes can be enriched and isolated from soft tissues and cells, and are biochemically accessible. Their high plasticity, the pharmacological (environmental) stimulation of their proliferation, and the defined morphological alterations during proliferation make them ideal model organelles with an interesting biology (for overview see Islinger, M., Grille, S., Fahimi, H. D., and M. Schrader: The peroxisome - an update on mysteries. Histochem Cell Biol. 137, 547–574, 2012). The investigation of peroxisome morphology and dynamics has become an exciting new field in cell biology and biomedical sciences because of its relation to organelle functionality and its impact on developmental and physiological processes.

近期论文

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Ferdinandusse, S SF, Falkenberg, K KF, Koster, J JK, Mooyer PM, Jones, R RJ, van Roermund, C C, Pizzino, a AP, Schrader M, Wanders, R RW, Vanderver, a AV, et al (In Press). ACBD5 deficiency causes a defect in peroxisomal very long-chain fatty acid metabolism. J Med Genet Full text. Magalhães, AC, Ferreira, AR, Gomes, S, Vieira, M, Gouveia, A, Valença, I, Islinger, M, Nascimento, R, Schrader M, Kagan, JC, et al (In Press). Peroxisomes are platforms for cytomegalovirus’ evasion from the cellular immune response. Scientific Reports Full text. Schrader M, Costello J, Godinho L, Azadi A, Islinger M (In Press). Proliferation and fission of peroxisomes - an update. Full text. Aroso M, Agricola B, Hacker C, Schrader M (In Press). Proteoglycans support proper granule formation in pancreatic acinar cells. Full text. Schrader M, Godinho L, Costello J, Islinger M (In Press). The different facets of organelle interplay - an overview of organelle interactions. Full text. Article has an altmetric score of 4 Lin C, Schuster M, Guimaraes SC, Ashwin P, Schrader M, Metz J, Hacker C, Gurr SJ, Steinberg G (2016). Active diffusion and microtubule-based transport oppose myosin forces to position organelles in cells. Nat Commun, 7 Abstract. Author URL. Full text. Article has an altmetric score of 47 Aroso M, Agricola B, Hacker C, Schrader M (2016). Addendum to the paper: Proteoglycans support proper granule formation in pancreatic AR42J cells. Histochem Cell Biol, 146(1). Author URL. Silva AM, Varela-Moreira A, Pereira Gomes C, Molinos M, Leite M, Almeida M, Ribeiro D, Schrader M, Figueiredo C, Barbosa M, et al (2015). Integrated Analysis of Biological Samples by Imaging Flow Cytometry. Microsc Microanal, 21 Suppl 5, 95-96. Author URL. Camões F, Islinger M, Guimarães SC, Kilaru S, Schuster M, Godinho LF, Steinberg G, Schrader M (2015). New insights into the peroxisomal protein inventory: Acyl-CoA oxidases and -dehydrogenases are an ancient feature of peroxisomes. Biochim Biophys Acta, 1853(1), 111-125. Abstract. Author URL. Full text. Article has an altmetric score of 1 Schrader M, Costello J, Godinho LF, Islinger M (2015). Peroxisome-mitochondria interplay and disease. Journal of Inherited Metabolic Disease, 38(4), 681-702. Abstract. Article has an altmetric score of 1 Schrader M, Costello J, Godinho LF, Islinger M (2015). Peroxisome-mitochondria interplay and disease. J Inherit Metab Dis, 38(4), 681-702. Abstract. Author URL. Full text. Article has an altmetric score of 1 Guimaraes SC, Schuster M, Bielska E, Dagdas G, Kilaru S, Meadows BR, Schrader M, Steinberg G (2015). Peroxisomes, lipid droplets, and endoplasmic reticulum "hitchhike" on motile early endosomes. J Cell Biol, 211(5), 945-954. Abstract. Author URL. Full text. Article has an altmetric score of 71 Aroso M, Agricola B, Hacker C, Schrader M (2015). Proteoglycans support proper granule formation in pancreatic acinar cells. Histochemistry and Cell Biology, 144(4), 331-346. Abstract. Williams C, Opalinski L, Landgraf C, Costello J, Schrader M, Krikken AM, Knoops K, Kram AM, Volkmer R, van der Klei IJ, et al (2015). The membrane remodeling protein Pex11p activates the GTPase Dnm1p during peroxisomal fission. Proc Natl Acad Sci U S A, 112(20), 6377-6382. Abstract. Author URL. Full text. Article has an altmetric score of 8 Huber N, Guimaraes S, Schrader M, Suter U, Niemann A (2013). Charcot-Marie-Tooth disease-associated mutants of GDAP1 dissociate its roles in peroxisomal and mitochondrial fission. EMBO Reports, 14(6), 545-552. Abstract. Full text. Article has an altmetric score of 1 Bonekamp NA, Islinger M, Lázaro MG, Schrader M (2013). Cytochemical detection of peroxisomes and mitochondria. Methods Mol Biol, 931, 467-482. Abstract. Author URL. Article has an altmetric score of 1 Castro I, Gouveia A, Ribeiro D, Schrader M (2013). Miro1 regulates microtubule-dependent motility of peroxisomes in mammalian cells. MOLECULAR BIOLOGY OF THE CELL, 24 Author URL. Schrader M, Grille S, Fahimi HD, Islinger M (2013). Peroxisome interactions and cross-talk with other subcellular compartments in animal cells. Subcell Biochem, 69, 1-22. Abstract. Author URL. Bonekamp NA, Grille S, Cardoso MJ, Almeida M, Aroso M, Gomes S, Magalhaes AC, Ribeiro D, Islinger M, Schrader M, et al (2013). Self-interaction of human Pex11pβ during peroxisomal growth and division. PLoS One, 8(1). Abstract. Author URL. Full text. Article has an altmetric score of 1 Islinger M, Gomes S, Bonekamp N, Magalhaes AC, Camoes F, Castro I, Almeida M, Schrader M (2013). Targeting of tail-anchored proteins to peroxisomes requires Pex19 and a highly positively charged tail. MOLECULAR BIOLOGY OF THE CELL, 24 Author URL.