个人简介

1994-1999: BSc in “Molecular Biology”, University of “St. Kliment Ohridski”, Faculty of Sciences, Department of Biology, Sofia, Bulgaria. 1999-2000: MSc in “Clinical Chemistry and Microbiology”, Department of Biology, University of “St. Kliment Ohridski”, & Bulgarian Academy of Sciences, Department of Molecular Biology and Department of Human Physiology. 2002-2004: MSc in “Plant Molecular Biology and Biotechnology”, Department of Biology, University of Crete, Greece. 2004-2009: PhD in “Molecular Plant-Microbe interactions” & “Molecular Microbiology”, Department of Biology, University of Crete, Greece. 2009-2011: Post-Doc research, Medical academy and Dept. of Biology, University of Crete, Greece. 2012-2015: Senior Research Associate, University of East Anglia (The Sainsbury Laboratory), Norwich, UK. 2015-present: Senior Lecturer, Dept. of Biosciences, University of Exeter, UK.

研究领域

Molecular Plant-Microbe Interactions Plant Immunobiology Molecular biology and Biotechnology of Disease Resistance in Plants Microbial Molecular Genomics/Proteomics Microbial Comparative Genomics and Phylogeny

My group investigates how plants resist disease and how resistance is overcome by pathogens. Using molecular biology, genetics, and biochemistry, we study the molecular basis of plant-microbe interactions to address microbial pathogenicity on susceptible hosts, and activation of innate immunity in disease-resistant hosts. To suppress host defence pathogens, of both plant and animals encode virulence components, known as “effector proteins”, which are translocated into host cells or are secreted to extracellular spaces. How these effectors work and the identification of their targets in the host tissues could help up to understand the molecular nature of the plant defence system. Plants’ and animals’ defence rely on a sophisticated innate immunity system that includes cell-surface and intracellular protein receptors. Pathogens recognition, by immune receptors, initiates a molecular signaling cascade leading to plant defence activation mechanisms. Plant intracellular immune receptors of the Nucleotide Binding-Leucine Rich Repeat family (NB-LRR or NLR) are encoded by Resistance (R) genes and have structural similarity with the mammalian intracellular NLR family (NOD-like receptor) receptors.

近期论文

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Sarris PF, Cevik V, Dagdas G, Jones JDG, Krasileva KV (2016). Comparative analysis of plant immune receptor architectures uncovers host proteins likely targeted by pathogens. BMC Biology, 14(1). Sarris PF, Duxbury Z, Huh SU, Ma Y, et. al. (2015). A plant immune receptor detects pathogen effectors that target WRKY transcription factors. Cell, 161, 1089-1100. Abstract. Trantas EA, Licciardello G, Almeida NF, Witek K, Strano CP, Duxbury Z, Ververidis F, Goumas DE, Jones JDG, Guttman DS, et al (2015). Comparative genomic analysis of multiple strains of two unusual plant pathogens: Pseudomonas corrugata and Pseudomonas mediterranea. Frontiers in Microbiology, 6(AUG), 811-830. Abstract. Sarris PF, Jones DGJ (2015). Plant Immune Receptors Mimic Pathogen Virulence Targets. Oncotarget, 6(19), 16824-16825. Abstract. Saucet SB, Ma Y, Sarris PF, et. al. (2015). Two linked pairs of Arabidopsis TNL resistance genes function independently to recognize bacterial effector AvrRps4. Nature Communications, 6 Abstract. Sarris PF, Ladoukakis M, Panopoulos NJ, et. al. (2014). A phage tail-derived element with wide distribution among both prokaryotic domains. A comparative genomic and phylogenetic study. Genome Biology and Evolution, 6(7), 1739-1747. Abstract. Trantas EA, Sarris PF, Pentari MG, et. al. (2014). Diversity among Pseudomonas corrugata and Pseudomonas mediterranea isolated from tomato and pepper showing symptoms of pith necrosis in Greece. Plant Pathology, 64(2), 307-318. Abstract. Licciardello G, Bella P, Devescovi G, Strano CP, Sarris PF, et. al. (2014). Draft genome sequence of Pseudomonas mediterranea strain CFBP 5447, a producer of filmable medium-chain-length polyhydroxyalkanoates. Genome Announcements, 2(6). Abstract. Williams SJ, Sohn KH, Wan L, Bernoux M, Sarris PF, et. al. (2014). Structural Basis for Assembly and Function of a Heterodimeric Plant Immune Receptor. Science, 344(6181), 299-303. Abstract. Sohn KH, Segonzac C, Rallapalli G, Sarris PF, et. al. (2014). The. nuclear. immune. receptor. RPS4. is. required. for. RRS1SLH1-induced. defense. activation in Arabidopsis thaliana. PLoS Genetics, 10(10). Abstract. Trantas EA, Sarris PF, Mpalantinaki E, et. al. (2013). A new genomovar of Pseudomonas cichorii, a causal agent of tomato pith necrosis. European Journal of Plant Pathology Abstract. Sarris PF, Trantas EA, Baltrus D, Bull C, et. al. (2013). Comparative genomics of multiple strains of Pseudomonas cannabina pv. alisalensis, a potential model pathogen of both Monocots and Dicots. PLoS One, 8(3). Abstract. Sarris PF, Trantas EA, et. al. (2012). First report of Pseudomonas viridiflava causing a bacterial blight of artichoke bract leaves. Plant Disease: an international journal of applied plant pathology, 96(81223), 1223-1223. Abstract. Sarris PF, Trantas EA, et. al. (2012). Pseudomonas viridiflava, a multi host plant pathogen with remarkable genetic polymorphism. PLoS One, 7(e36090). Abstract. Gazi AD, Sarris PF, Fadouloglou VE, et. al. (2012). Targeting injectisomes of virulence: Benefits of 30 years of research on bacterial secretion systems, to crop protection. BMC Microbiology, 12, 188-203. Abstract. Skandalis N, Sarris PF, Panopoulos NJ (2012). Targeting injectisomes of virulence: Benefits of 30 years of research on bacterial secretion systems, to crop protection. Hellenic Plant Protection Journal, 5(2), 31-47. Abstract. Sarris PF, Trantas EA, et. al. (2011). First report of potato blackleg caused by a new clade of biovar 3 Dickeya sp. (Pectobacterium chrysanthemi) in Greece. New Disease Reports, 24(21). Abstract. Sarris PF, Karademiris K, Gao S, Jin H, et. al. (2011). Phytobacterial Type III Effectors Enhance Plant Sense-Post Transcriptional Gene Silencing Independently of R Gene-Effector Recognition. Molecular Plant-Microbe Interactions, 24(8), 907-917. Abstract. Sarris PF, Scoulica E (2011). Pseudomonas entomophila & Pseudomonas mendocina: Potential models for studying the bacterial Type VI Secretion System. Infection, Genetics and Evolution, 11(6), 1352-1360. Abstract. Sarris PF, Zoumadakis C, Panopoulos NJ, et. al. (2010). Distribution of the putative type VI secretion system core genes in Klebsiella spp. Infection, Genetics and Evolution, 11, 157-166. Abstract.