Santos, Eduarda - University of Exeter - Disciplines of Biosciences

个人简介

2010 Postgraduate Certificate in Academic Practice, University of Exeter, UK 2002 PhD in Fish Reproductive Endocrinology, Brunel University, UK 1995 Degree in Aquatic Sciences, University of Porto, Portugal Career 2014-Present Senior Lecturer in Environmental Biology, University of Exeter 2008-2014 Lecturer in Environmental Biology, University of Exeter 2005-2008 NERC Postdoctoral Researcher, University of Exeter 2001-2005 BBSRC Postdoctoral Researcher, University of Exeter

研究领域

The research focus in my group is to understand the dynamics of sexual development and function, and how environmental stressors impact on reproduction and health in fish. This area of research is a vast and exiting one and potentially benefits aquaculture and fisheries as well as environmental and human health. Our research to date spanned from investigations into the endocrine regulation of oocyte development in rainbow trout (Oncorhynchus mykiss), to the identification of the gene pathways underlying sexual dimorphism in the zebrafish (Danio rerio) and how they are disrupted by exposure to oestrogens. This work established links between the gene pathways disrupted by ethinyloestradiol, a potent oestrogen present in the contraceptive pill and widespread in the environment, and the decrease in fecundity in zebrafish colonies. The project raised wide interest and was presented at the Royal Society’s Summer Science Exhibition in 2004. Further research has aimed to establishing the effects of exposure to model environmental chemicals (including a synthetic oestrogen (ethinyloestradiol), a metal (copper) and a polyaromatic hydrocarbon (dibenzanthracene)) at the individual and population levels, in three-spined stickleback (Gasterosteus aculeatus). This work resulted in the discovery of the involvement of the cholesterol biosynthesis pathway in the toxicological response to copper in this species. These studies were conducted using a systems biology approach where genomics, transcriptomics, metabolomics and population level datasets are integrated to generate a global picture of the consequences of exposure to environmental chemicals in wild populations of fish. Current projects in my laboratory are focusing on the effects of chemicals stressors on the brown trout (Salmo trutta), a species of ecological and economic importance in UK waters. To address this issue, we are sequencing the transcriptome of the brown trout and using RNA-Seq strategies to provide a comprehensive analysis of the mechanisms of toxicity of a range of chemicals on this species. We are also investigating the effects of combined stressors on the physiology of a number of fish species, to provide a more realistic analysis of the stressors that fish encounter in their environment.

近期论文

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Laing LV, Viana J, Dempster EL, Trznadel M, Trunkfield LA, Uren Webster TM, van Aerle R, Paull GC, Wilson RJ, Mill J, et al (2016). Bisphenol a causes reproductive toxicity, decreases dnmt1 transcription, and reduces global DNA methylation in breeding zebrafish (Danio rerio). Epigenetics, 11(7), 526-538. Abstract. Author URL. Full text. Article has an altmetric score of 17 Fitzgerald JA, Jameson HM, Fowler VH, Bond GL, Bickley LK, Webster TM, Bury NR, Wilson RJ, Santos EM (2016). Hypoxia Suppressed Copper Toxicity during Early Development in Zebrafish Embryos in a Process Mediated by the Activation of the HIF Signaling Pathway. Environ Sci Technol, 50(8), 4502-4512. Abstract. Author URL. Full text. Article has an altmetric score of 10 Verbruggen B, Bickley LK, van Aerle R, Bateman KS, Stentiford GD, Santos EM, Tyler CR (2016). Molecular Mechanisms of White Spot Syndrome Virus Infection and Perspectives on Treatments. Viruses, 8(1). Abstract. Author URL. Full text. Article has an altmetric score of 8 Verbruggen B, Bickley LK, Santos EM, Tyler CR, Stentiford GD, Bateman KS, van Aerle R (2015). De novo assembly of the Carcinus maenas transcriptome and characterization of innate immune system pathways. BMC Genomics, 16 Abstract. Author URL. Full text. Article has an altmetric score of 17 Uren Webster TM, Santos EM (2015). Global transcriptomic profiling demonstrates induction of oxidative stress and of compensatory cellular stress responses in brown trout exposed to glyphosate and Roundup. BMC Genomics, 16 Abstract. Author URL. Full text. Article has an altmetric score of 20 Uren Webster TM, Shears JA, Moore K, Santos EM (2015). Identification of conserved hepatic transcriptomic responses to 17β-estradiol using high-throughput sequencing in brown trout. Physiol Genomics, 47(9), 420-431. Abstract. Author URL. Full text. Article has an altmetric score of 9 Uren Webster TM, Perry MH, Santos EM (2015). The herbicide linuron inhibits cholesterol biosynthesis and induces cellular stress responses in brown trout. Environ Sci Technol, 49(5), 3110-3118. Abstract. Author URL. Full text. Article has an altmetric score of 5 Uren Webster TM, Laing LV, Florance H, Santos EM (2014). Effects of glyphosate and its formulation, roundup, on reproduction in zebrafish (Danio rerio). Environ Sci Technol, 48(2), 1271-1279. Abstract. Author URL. Full text. Article has an altmetric score of 9 Santos E, Webster TU (2014). Secrets of cornwall's metal-tolerant trout. Planet Earth(SPRING), 28-29. Uren Webster TM, Bury N, van Aerle R, Santos EM (2013). Global transcriptome profiling reveals molecular mechanisms of metal tolerance in a chronically exposed wild population of brown trout. Environ Sci Technol, 47(15), 8869-8877. Abstract. Author URL. Full text. Article has an altmetric score of 45 van Aerle R, Lange A, Moorhouse A, Paszkiewicz K, Ball K, Johnston BD, de-Bastos E, Booth T, Tyler CR, Santos EM, et al (2013). Molecular mechanisms of toxicity of silver nanoparticles in zebrafish embryos. Environ Sci Technol, 47(14), 8005-8014. Abstract. Author URL. Full text. Article has an altmetric score of 7 Santos EM, Hamilton PB, Coe TS, Ball JS, Cook AC, Katsiadaki I, Tyler CR (2013). Population bottlenecks, genetic diversity and breeding ability of the three-spined stickleback (Gasterosteus aculeatus) from three polluted English Rivers. Aquatic Toxicology, 142-143, 264-271. Abstract. Article has an altmetric score of 1 Fu J, Han J, Zhou B, Gong Z, Santos EM, Huo X, Zheng W, Liu H, Yu H, Liu C, et al (2013). Toxicogenomic responses of zebrafish embryos/larvae to tris(1,3-dichloro-2-propyl) phosphate (TDCPP) reveal possible molecular mechanisms of developmental toxicity. Environ Sci Technol, 47(18), 10574-10582. Abstract. Author URL. Article has an altmetric score of 2 Al-Jandal NJ, Whittamore JM, Santos EM, Wilson RW (2011). The influence of 17β-estradiol on intestinal calcium carbonate precipitation and osmoregulation in seawater-acclimated rainbow trout (Oncorhynchus mykiss). J Exp Biol, 214(Pt 16), 2791-2798. Abstract. Author URL. Scown TM, Santos EM, Johnston BD, Gaiser B, Baalousha M, Mitov S, Lead JR, Stone V, Fernandes TF, Jepson M, et al (2010). Effects of aqueous exposure to silver nanoparticles of different sizes in rainbow trout. Toxicol Sci, 115(2), 521-534. Abstract. Author URL. Katsiadaki I, Williams TD, Ball JS, Bean TP, Sanders MB, Wu H, Santos EM, Brown MM, Baker P, Ortega F, et al (2010). Hepatic transcriptomic and metabolomic responses in the Stickleback (Gasterosteus aculeatus) exposed to ethinyl-estradiol. Aquat Toxicol, 97(3), 174-187. Abstract. Author URL. Article has an altmetric score of 3 Santos EM, Ball JS, Williams TD, Wu H, Ortega F, van Aerle R, Katsiadaki I, Falciani F, Viant MR, Chipman JK, et al (2010). Identifying health impacts of exposure to copper using transcriptomics and metabolomics in a fish model. Environ Sci Technol, 44(2), 820-826. Abstract. Author URL. Article has an altmetric score of 3 Van Aggelen G, Ankley GT, Baldwin WS, Bearden DW, Benson WH, Chipman JK, Collette TW, Craft JA, Denslow ND, Embry MR, et al (2010). Integrating omic technologies into aquatic ecological risk assessment and environmental monitoring: hurdles, achievements, and future outlook. Environ Health Perspect, 118(1), 1-5. Abstract. Author URL. Article has an altmetric score of 9 Uren-Webster TM, Lewis C, Filby AL, Paull GC, Santos EM (2010). Mechanisms of toxicity of di(2-ethylhexyl) phthalate on the reproductive health of male zebrafish. Aquat Toxicol, 99(3), 360-369. Abstract. Author URL. Oehlmann J, Schulte-Oehlmann U, Kloas W, Jagnytsch O, Lutz I, Kusk KO, Wollenberger L, Santos EM, Paull GC, VanLook KJW, et al (2009). A critical analysis of the biological impacts of plasticizers on wildlife. Philosophical Transactions of the Royal Society B: Biological Sciences, 364(1526), 2047-2062.