Ramsdale, Mark - University of Exeter - Disciplines of Biosciences

个人简介

2006-2007 Postgraduate Certificate in Academic Practice, University of Exeter 1995 PhD Biological Sciences, University of Bath 1991 BSc (Hons) Applied Biology, University of Bath Career 2015 - present Director of Education (Biosciences) 2006-2015 Lecturer in Molecular Microbiology, School of Biosciences, University of Exeter 2004-2006 Independent Research Fellow, School of Medical Sciences, University of Aberdeen 2000-2003 Lloyds Tercentenary Foundation Fellow, School of Medical Sciences, University of Aberdeen 1998-2000 Research Fellow, School of Medical Sciences, University of Aberdeen 1996-1998 Research Fellow, Department of Zoology, University of Cambridge 1995-1996 Scientist, Pfizer, Sandwich, Kent

研究领域

The main focus of work in my lab is to further our understanding of stress and programmed cell death responses exhibited by fungi (in particular Candida albicans). This is important since fungal diseases of man have assumed great significance due to changes in the demographic status of the human population, changes in the management practices for chronic health conditions, and the increased use of immunocompromising agents in medicine. Due to similarities in the basic cellular organization of pathogenic fungi and their animal hosts, the control of such diseases poses considerable problems for clinicians. New strategies must therefore be implemented to assist in the identification of novel antifungal agents. We are therefore aiming to (i) identify and characterize the different types of cell death response (apoptotic, autophagic and necrotic) shown by fungi under different conditions, (ii) highlight the key differences between the cell death and stress responses of mammals and fungi, and (iii) identify regulators core to the fungal cell death response using a combination of traditional genetics and genomics based technologies.

近期论文

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Ramsdale M (2012). Programmed cell death in the cellular differentiation of microbial eukaryotes. Current Opinion in Microbiology, 15(6), 646-652. Abstract. Article has an altmetric score of 8 Ramsdale M (2012). Programmed cell death in the cellular differentiation of microbial eukaryotes. Curr Opin Microbiol, 15(6), 646-652. Abstract. Author URL. Article has an altmetric score of 8 Wilkinson D, Ramsdale M (2011). Proteases and caspase-like activity in the yeast Saccharomyces cerevisiae. Biochemical Society Transactions, 39, 1502-1508. Abstract. Full text. Coste AT, Ramsdale M, Ischer F, Sanglard D (2008). Divergent functions of three Candida albicans zinc-cluster transcription factors (CTA4, ASG1 and CTF1) complementing pleiotropic drug resistance in Saccharomyces cerevisiae. Microbiology, 154(Pt 5), 1491-1501. Abstract. Author URL. Ramsdale M, Selway L, Stead D, Walker J, Yin Z, Nicholls SM, Crowe J, Sheils EM, Brown AJ (2008). MNL1 regulates weak acid-induced stress responses of the fungal pathogen Candida albicans. Mol Biol Cell, 19(10), 4393-4403. Abstract. Author URL. Full text. Ramsdale M (2008). Programmed cell death in pathogenic fungi. Biochim Biophys Acta, 1783(7), 1369-1380. Abstract. Author URL. Full text. Ramsdale, M. (2007). Fungal Immunology from an organ perspective. Mycological Research Ramsdale, M. (2006). Candida transcriptional modules online. Mycological Research, 110, 753-754. Ramsdale M, Crowe JD, Phillips AJ (2006). Ras pathway signalling accelerated programmed cell death in the pathogenic fungus Candida albicans. Proceedings of the National Academy of Sciences, 103(3), 726-731. Ramsdale M, Brown AJP, Dennison PMJ, Manson CL (2005). Gene disruption in Candida albicans using a synthetic codon-optimised Cre-loxP system. Fungal Genetics and Biology, 42(9), 737-748. Ramsdale M, Phillips AJ, Sudbery I (2003). Apoptosis induced by environmental stress and amphotericin B in Candida albicans. Proceedings of the National Academy of Sciences, 100(24), 14327-14332. Article has an altmetric score of 1 Phillips AJ, Sudbery I, Ramsdale M (2003). Apoptosis induced by environmental stresses and amphotericin B in Candida albicans. Proceedings of the National Academy of Sciences of the United States of America, 100(SUPPL. 2), 14327-14332. Abstract. Article has an altmetric score of 1 Ramsdale M (2003). Fungi and the bare necessities of life. Mycologist, 17(1). Ramsdale, M. (2003). Fungi and the bare necessities of life: minimalism in the genome of Encephalitozoon cuniculi. Mycologist, 17 Ramsdale, M. (2001). Fungi with a sense of time: molecular genetics of temporal organization in Neurospora crassa. Mycologist, 15, 10-15. Ramsdale M, Gooch VD, Lakin-Thomas PL (2001). Rhythms of differentiation and diacylglycerol in Neurospora crassa. Philosophical Transactions of the Royal Society B Biological Sciences, 356(1415), 1711-1715. Ramsdale M (2001). Sphingolipid-mediated cell death responses in the yeasts Candida albicans and Saccharomyces cerevisiae. YEAST, 18, S173-S173. Author URL. Brown AJ, Barelle CJ, Budge S, Duncan J, Harris S, Lee PR, Leng P, Macaskill S, Abdul Murad AM, Ramsdale M, et al (2000). Gene regulation during morphogenesis in Candida albicans. Contrib Microbiol, 5, 112-125. Author URL. Ramsdale M, Lakin-Thomas PL (2000). sn-1,2-diacylglycerol levels in the fungus Neurospora crassa display circadian rhythmicity. J Biol Chem, 275(36), 27541-27550. Abstract. Author URL. Ramsdale M, Rayner ADM (1996). Imbalanced nuclear ratios, post-germination mortality and phenotype-genotype relationships in allopatrically-derived heterokaryons of Heterobasidion annosum. New Phytologist, 133(2), 303-319. Abstract.