Porter, Steven - University of Exeter - Disciplines of Biosciences

个人简介

1998-2002 D.Phil. (Biochemistry), Jesus College, University of Oxford 1994-1998 M.Biochem. (Biochemistry) First class honours. Jesus College, University of Oxford Career 2009-present Lecturer in Biochemistry, School of Biosciences, University of Exeter 2006-2009 Postdoctoral Research Assistant, Oxford Centre for Integrative Systems Biology, University of Oxford 2001-2006 Junior Research Fellowship (BTP Research Fellow), Pembroke College, University of Oxford 2001-2006 Postdoctoral Research Assistant, Department of Biochemistry, University of Oxford

研究领域

My research group focuses on bacterial signal transduction and in particular on multikinase-networks, which are two-component signalling networks comprising multiple sensor kinases. In these networks, the sensor kinases work together to detect and integrate signals and to decide upon an appropriate response. We are interested in mechanisms of signal integration and amplification and particularly on how complex behaviour can be controlled by these sensory circuits built from such simple components. The main focus of my group is on the GacS multikinase network which controls the transition between acute and chronic modes of virulence in Pseudomonas aeruginosa.

近期论文

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Amin M, Kothamachu VB, Feliu E, Scharf BE, Porter SL, Soyer OS (2014). Phosphate sink containing two-component signaling systems as tunable threshold devices. PLoS Comput Biol, 10(10). Abstract. Author URL. Full text. Article has an altmetric score of 1 Amin M, Porter SL, Soyer OS (2013). Split histidine kinases enable ultrasensitivity and bistability in two-component signaling networks. PLoS Comput Biol, 9(3). Abstract. Author URL. Article has an altmetric score of 2 Porter SL, Wilkinson DA, Byles ED, Wadhams GH, Taylor S, Saunders NJ, Armitage JP (2011). Genome sequence of Rhodobacter sphaeroides Strain WS8N. J Bacteriol, 193(15), 4027-4028. Abstract. Author URL. Porter SL, Wadhams GH, Armitage JP (2011). Signal processing in complex chemotaxis pathways. Nat Rev Microbiol, 9(3), 153-165. Abstract. Author URL. Tindall MJ, Porter SL, Maini PK, Armitage JP (2010). Modeling chemotaxis reveals the role of reversed phosphotransfer and a bi-functional kinase-phosphatase. PLoS Comput Biol, 6(8). Abstract. Author URL. Full text. Scott KA, Porter SL, Bagg EAL, Hamer R, Hill JL, Wilkinson DA, Armitage JP (2010). Specificity of localization and phosphotransfer in the CheA proteins of Rhodobacter sphaeroides. Molecular Microbiology Abstract. Full text. Bell CH, Porter SL, Strawson A, Stuart DI, Armitage JP (2010). Using structural information to change the phosphotransfer specificity of a two-component chemotaxis signalling complex. PLoS Biol, 8(2). Abstract. Author URL. Full text. Ind AC, Porter SL, Brown MT, Byles ED, de Beyer JA, Godfrey SA, Armitage JP (2009). Inducible-expression plasmid for Rhodobacter sphaeroides and Paracoccus denitrificans. Appl Environ Microbiol, 75(20), 6613-6615. Abstract. Author URL. Tindall MJ, Porter SL, Wadhams GH, Maini PK, Armitage JP (2009). Spatiotemporal modelling of CheY complexes in Escherichia coli chemotaxis. Prog Biophys Mol Biol, 100(1-3), 40-46. Abstract. Author URL. Porter SL, Roberts MA, Manning CS, Armitage JP (2008). A bifunctional kinase-phosphatase in bacterial chemotaxis. Proc Natl Acad Sci U S A, 105(47), 18531-18536. Abstract. Author URL. Full text. Article has an altmetric score of 1 Tindall MJ, Porter SL, Maini PK, Gaglia G, Armitage JP (2008). Overview of mathematical approaches used to model bacterial chemotaxis I: the single cell. Bull Math Biol, 70(6), 1525-1569. Abstract. Author URL. Tindall MJ, Maini PK, Porter SL, Armitage JP (2008). Overview of mathematical approaches used to model bacterial chemotaxis II: bacterial populations. Bull Math Biol, 70(6), 1570-1607. Abstract. Author URL. Porter SL, Wadhams GH, Armitage JP (2008). Rhodobacter sphaeroides: complexity in chemotactic signalling. Trends Microbiol, 16(6), 251-260. Abstract. Author URL. Porter SL, Wadhams GH, Armitage JP (2007). In vivo and in vitro analysis of the Rhodobacter sphaeroides chemotaxis signaling complexes. Methods Enzymol, 423, 392-413. Abstract. Author URL. Slovak PM, Porter SL, Armitage JP (2006). Differential localization of Mre proteins with PBP2 in Rhodobacter sphaeroides. J Bacteriol, 188(5), 1691-1700. Abstract. Author URL. Rasmussen AA, Wegener-Feldbrügge S, Porter SL, Armitage JP, Søgaard-Andersen L (2006). Four signalling domains in the hybrid histidine protein kinase RodK of Myxococcus xanthus are required for activity. Mol Microbiol, 60(2), 525-534. Abstract. Author URL. Porter SL, Wadhams GH, Martin AC, Byles ED, Lancaster DE, Armitage JP (2006). The CheYs of Rhodobacter sphaeroides. J Biol Chem, 281(43), 32694-32704. Abstract. Author URL. Rasmussen AA, Porter SL, Armitage JP, Søgaard-Andersen L (2005). Coupling of multicellular morphogenesis and cellular differentiation by an unusual hybrid histidine protein kinase in Myxococcus xanthus. Mol Microbiol, 56(5), 1358-1372. Abstract. Author URL. Porter SL, Armitage JP (2004). Chemotaxis in Rhodobacter sphaeroides requires an atypical histidine protein kinase. J Biol Chem, 279(52), 54573-54580. Abstract. Author URL. Porter SL, Armitage JP (2002). Phosphotransfer in Rhodobacter sphaeroides chemotaxis. J Mol Biol, 324(1), 35-45. Abstract. Author URL.