Perry, Alexis - University of Exeter - Disciplines of Biosciences

个人简介

MSci Chemistry with Medicinal Chemistry (University of Glasgow, 2001), PhD (University of Leeds, 2005) Career Post-doctoral research: 2005-2006, University of Sydney; 2007-2009, University of York; 2009-2014, University of Exeter.

研究领域

My research career has involved the both the development of novel synthetic methodologies and the application of organic synthesis in diverse and inspiring research fields – from molecular electronics and graphene derivatisation through to stem cell research and modulation of mitochondrial behaviour. My current research interests include the design and synthesis of novel hydrogen sulphide donors (in collaboration with Dr. Mark Wood (Biosciences, Exeter) and Dr. Matt Whiteman (Medical School, Exeter)) and the development of graphene-based sensors for biologically important targets (in collaboration with Dr. Dave Horsell and Dr. Steve Green (both Physics, Exeter).

近期论文

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Wood ME, Alexander BE, Coles SJ, Fox BC, Khan TF, Maliszewski J, Perry A, Pitak MB, Whiteman M (In Press). investigating the generation of hydrogen sulfide from the phosphonamidodithioate slow-release donor GYY4137. MedChemComm Gero D, Torregrossa R, Perry A, Waters A, Le-Trionnaire S, Whatmore JL, Wood M, Whiteman M (2016). The novel mitochondria-targeted hydrogen sulfide (H2S) donors AP123 and AP39 protect against hyperglycemic injury in microvascular endothelial cells in vitro. Pharmacol Res, 113(Pt A), 186-198. Abstract. Author URL. Full text. Perry A, Green SJ, Horsell DW, Hornett SM, Wood ME (2015). A pyrene-appended spiropyran for selective photo-switchable binding of Zn(II): UV-visible and fluorescence spectroscopy studies of binding and non-covalent attachment to graphene, graphene oxide and carbon nanotubes. Tetrahedron Abstract. Perry A, Green SJ, Horsell DW, Homett SM, Wood ME (2015). A pyrene-appended spiropyran for selective photo-switchable binding of Zn(II): UV-visible and fluorescence spectroscopy studies of binding and non-covalent attachment to graphene, graphene oxide and carbon nanotubes. TETRAHEDRON, 71(38), 6776-6783. Author URL. Full text. Tomasova L, Pavlovicova M, Malekova L, Misak A, Kristek F, Grman M, Cacanyiova S, Tomasek M, Tomaskova Z, Perry A, et al (2015). Effects of AP39, a novel triphenylphosphonium derivatised anethole dithiolethione hydrogen sulfide donor, on rat haemodynamic parameters and chloride and calcium Ca<inf>v</inf>3 and RyR2 channels. Nitric Oxide - Biology and Chemistry, 46, 131-144. Abstract. Tomasova L, Pavlovicova M, Malekova L, Misak A, Kristek F, Grman M, Cacanyiova S, Tomasek M, Tomaskova Z, Perry A, et al (2015). Effects of AP39, a novel triphenylphosphonium derivatised anethole dithiolethione hydrogen sulfide donor, on rat haemodynamic parameters and chloride and calcium Cav3 and RyR2 channels. Nitric Oxide, 46, 131-144. Abstract. Author URL. Full text. Whiteman M, Perry A, Zhou Z, Bucci M, Papapetropoulos A, Cirino G, Wood ME (2015). Phosphinodithioate and Phosphoramidodithioate Hydrogen Sulfide Donors. Handb Exp Pharmacol, 230, 337-363. Abstract. Author URL. Hurst TE, Gorman RM, Drouhin P, Perry A, Taylor RJK (2014). A direct C-H/Ar-H coupling approach to oxindoles, thio-oxindoles, 3,4-dihydro-1 H-quinolin-2-ones, and 1,2,3,4-tetrahydroquinolines. Chemistry (Weinheim an der Bergstrasse, Germany), 20(43), 14063-14073. Abstract. Hurst TE, Gorman RM, Drouhin P, Perry A, Taylor RJ (2014). A direct C-H/Ar-H coupling approach to oxindoles, thio-oxindoles, 3,4-dihydro-1 H-quinolin-2-ones, and 1,2,3,4-tetrahydroquinolines. Chemistry, 20(43), 14063-14073. Abstract. Author URL. Szczesny B, Módis K, Yanagi K, Coletta C, Le Trionnaire S, Perry A, Wood ME, Whiteman M, Szabo C (2014). AP39, a novel mitochondria-targeted hydrogen sulfide donor, stimulates cellular bioenergetics, exerts cytoprotective effects and protects against the loss of mitochondrial DNA integrity in oxidatively stressed endothelial cells in vitro. Nitric Oxide - Biology and Chemistry, 41, 120-130. Abstract. Szczesny B, Módis K, Yanagi K, Coletta C, Le Trionnaire S, Perry A, Wood ME, Whiteman M, Szabo C (2014). AP39, a novel mitochondria-targeted hydrogen sulfide donor, stimulates cellular bioenergetics, exerts cytoprotective effects and protects against the loss of mitochondrial DNA integrity in oxidatively stressed endothelial cells in vitro. Nitric Oxide, 41, 120-130. Abstract. Author URL. Full text. Le Trionnaire S, Perry A, Szczesny B, Szabo C, Winyard PG, Whatmore JL, Wood ME, Whiteman M (2014). The synthesis and functional evaluation of a mitochondria-targeted hydrogen sulfide donor, (10-oxo-10-(4-(3-thioxo-3H-1,2-dithiol-5-yl)phenoxy)decyl) triphenylphosphonium bromide (AP39). MedChemComm, 5(6), 728-736. Abstract. Full text. Yong QC, Cheong JL, Hua F, Deng LW, Khoo YM, Lee HS, Perry A, Wood M, Whiteman M, Bian JS, et al (2011). Regulation of heart function by endogenous gaseous mediators-crosstalk between nitric oxide and hydrogen sulfide. Antioxid Redox Signal, 14(11), 2081-2091. Abstract. Author URL. Klein JE, Perry A, Pugh DS, Taylor RJ (2010). First C-H activation route to oxindoles using copper catalysis. Org Lett, 12(15), 3446-3449. Abstract. Author URL. Pugh DS, Klein JEMN, Perry A, Taylor RJK (2010). Preparation of 3-alkyl-oxindoles by copper(II)-mediated C-H, Ar-H coupling followed by decarboxyalkylation. Synlett(6), 934-938. Abstract. Lubkoll J, Millemaggi A, Perry A, Taylor RJK (2010). Tandem Horner-Wadsworth-Emmons/Heck procedures for the preparation of 3-alkenyl-oxindoles: the synthesis of Semaxanib and GW441756. Tetrahedron, 66(33), 6606-6612. Abstract. Nelson A, Bone H, Damiano M, Welham M, Bartlett S, Perry A, Cordier CJ, Warriner S, Leach SG, Morton D, et al (2009). Exploring biologically-relevant chemical space with macrocyclic ligands. ABSTRACTS OF PAPERS OF THE AMERICAN CHEMICAL SOCIETY, 238 Author URL. Bone HK, Damiano T, Bartlett S, Perry A, Letchford J, Ripoll YS, Nelson AS, Welham MJ (2009). Involvement of GSK-3 in Regulation of Murine Embryonic Stem Cell Self-Renewal Revealed by a Series of Bisindolylmaleimides. Chemistry and Biology, 16(1), 15-27. Abstract. Perry A, Taylor RJ (2009). Oxindole synthesis by direct C-H, Ar-H coupling. Chem Commun (Camb)(22), 3249-3251. Abstract. Author URL. Millemaggi A, Perry A, Whitwood AC, Taylor RJK (2009). Telescoped enolate arylation/HWE procedure for the preparation of 3-alkenyl-oxindoles: the first synthesis of soulieotine. European Journal of Organic Chemistry(18), 2947-2952. Abstract.