Michell, Steve - University of Exeter - Disciplines of Biosciences

个人简介

1993: BSc, Chemistry and Biochemistry, Imperial College. 1999: PhD, St. Mary‘s Hospital, Imperial College. 2011: Fellow of the Higher Education Academy Career 2012-Present Senior Lecturer of Molecular Microbiology, School of Biosciences, University of Exeter 2007-2012: Lecturer of Molecular Microbiology, School of Biosciences, University of Exeter 2002-2007: Research Scientist at the Defence Science Technology Laboratories 1994-2002: Research Scientist at the Veterinary Laboratories Agency

研究领域

My research aims to identify and characterise novel virulence factors from human pathogens to further understand mechanisms of bacterial pathogenesis. One area of particular interest is bacterial post-translational modification. Several pathogens secrete proteins which are acylated or glycosylated, or both, and function as virulence factors. Understanding the mechanisms by which pathogens modify their proteins and the contribution of these modifications to disease is the main focus of my research. I also have an interest in whole genome sequencing of bacterial pathogens as an approach to identifying novel virulence factors. Current projects include study of the mechanism of protein acylation by Clostridium difficle and its role in virulence. Identification of novel virulence factors of Vibrio vulnificus. I also have collaborative research projects with Professor Rick Titball looking at Burkholderia pseudomallei and Coxiella Burnetti.

近期论文

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Nandi T, Holden MT, Didelot X, Mehershahi K, Boddey JA, Beacham I, Peak I, Harting J, Baybayan P, Guo Y, et al (2015). Burkholderia pseudomallei sequencing identifies genomic clades with distinct recombination, accessory, and epigenetic profiles. Genome Res, 25(1), 129-141. Abstract. Author URL. Article has an altmetric score of 12 Aiken SS, Cooper JJ, Florance H, Robinson MT, Michell S (2015). Local Release of Antibiotics for Surgical Site Infection Management Using High-Purity Calcium Sulfate: an in Vitro Elution Study. SURGICAL INFECTIONS, 16(1), 54-61. Author URL. Article has an altmetric score of 1 Charlton TM, Kovacs-Simon A, Michell SL, Fairweather NF, Tate EW (2015). Quantitative Lipoproteomics in Clostridium difficile Reveals a Role for Lipoproteins in Sporulation. CHEMISTRY & BIOLOGY, 22(11), 1562-1573. Author URL. Article has an altmetric score of 4 Peano C, Chiaramonte F, Motta S, Pietrelli A, Jaillon S, Rossi E, Consolandi C, Champion OL, Michell SL, Freddi L, et al (2014). Gene and protein expression in response to different growth temperatures and oxygen availability in Burkholderia thailandensis. PLoS One, 9(3). Abstract. Author URL. Article has an altmetric score of 1 Kovacs-Simon A, Leuzzi R, Kasendra M, Minton N, Titball RW, Michell SL (2014). Lipoprotein CD0873 is a novel adhesin of Clostridium difficile. J Infect Dis, 210(2), 274-284. Abstract. Author URL. Article has an altmetric score of 5 Butt E, Foster JA, Keedwell E, Bell JE, Titball RW, Bhangu A, Michell SL, Sheridan R (2013). Derivation and validation of a simple, accurate and robust prediction rule for risk of mortality in patients with Clostridium difficile infection. BMC Infect Dis, 13 Abstract. Author URL. Full text. Article has an altmetric score of 14 He M, Miyajima F, Roberts P, Ellison L, Pickard DJ, Martin MJ, Connor TR, Harris SR, Fairley D, Bamford KB, et al (2013). Emergence and global spread of epidemic healthcare-associated Clostridium difficile. Nature Genetics, 45(1), 109-113. Abstract. Article has an altmetric score of 117 Gourlay LJ, Peri C, Ferrer-Navarro M, Conchillo-Solé O, Gori A, Rinchai D, Thomas RJ, Champion OL, Michell SL, Kewcharoenwong C, et al (2013). Exploiting the Burkholderia pseudomallei acute phase antigen BPSL2765 for structure-based epitope discovery/design in structural vaccinology. Chem Biol, 20(9), 1147-1156. Abstract. Author URL. Article has an altmetric score of 2 Michell SL (2012). A better understanding of what makes some proteins "fat". J Bacteriol, 194(9), 2129-2130. Author URL. Article has an altmetric score of 1 He M, Miyajima F, Roberts P, Ellison L, Pickard DJ, Martin MJ, Connor TR, Harris SR, Fairley D, Bamford KB, et al (2012). Emergence and global spread of epidemic healthcare-associated Clostridium difficile. Nature Genetics Foster JAH, Butt JEC, Bell J, Goff A, Morgan C, Hancock J, Carmichael C, Keedwell EC, Michell SLI, Sheridan RP, et al (2012). IMPROVING CLINICAL MANAGEMENT IN CLOSTRIDIUM DIFFICILE: FAECAL CALPROTECTIN DOES NOT PREDICT SEVERITY, RECURRENCE OR MORTALITY. AGE AND AGEING, 41, 72-72. Author URL. Thomas RM, Twine SM, Fulton KM, Tessier L, Kilmury SL, Ding W, Harmer N, Michell SL, Oyston PC, Titball RW, et al (2011). Glycosylation of DsbA in Francisella tularensis subsp. tularensis. J Bacteriol, 193(19), 5498-5509. Abstract. Author URL. Kovacs-Simon A, Titball RW, Michell SL (2011). Lipoproteins of bacterial pathogens. Infect Immun, 79(2), 548-561. Abstract. Author URL. Article has an altmetric score of 4 Wand ME, Müller CM, Titball RW, Michell SL (2011). Macrophage and Galleria mellonella infection models reflect the virulence of naturally occurring isolates of B. pseudomallei, B. thailandensis and B. oklahomensis. BMC Microbiol, 11(1). Abstract. Author URL. Full text. Wang W, Hale C, Goulding D, Haslam SM, Tissot B, Lindsay C, Michell S, Titball R, Yu J, Toribio AL, et al (2011). Mannosidase 2, alpha 1 deficiency is associated with ricin resistance in embryonic stem (ES) cells. PLoS One, 6(8). Abstract. Author URL. Full text. Vanaporn M, Wand M, Michell SL, Sarkar-Tyson M, Ireland P, Goldman S, Kewcharoenwong C, Rinchai D, Lertmemongkolchai G, Titball RW, et al (2011). Superoxide dismutase C is required for intracellular survival and virulence of Burkholderia pseudomallei. Microbiology, 157(Pt 8), 2392-2400. Abstract. Author URL. Michell SL, Dean RE, Eyles JE, Hartley MG, Waters E, Prior JL, Titball RW, Oyston PC (2010). Deletion of the Bacillus anthracis capB homologue in Francisella tularensis subspecies tularensis generates an attenuated strain that protects mice against virulent tularaemia. J Med Microbiol, 59(Pt 11), 1275-1284. Abstract. Author URL. Forslund AL, Salomonsson EN, Golovliov I, Kuoppa K, Michell S, Titball R, Oyston P, Noppa L, Sjöstedt A, Forsberg A, et al (2010). The type IV pilin, PilA, is required for full virulence of Francisella tularensis subspecies tularensis. BMC Microbiol, 10 Abstract. Author URL. Champion MD, Zeng Q, Nix EB, Nano FE, Keim P, Kodira CD, Borowsky M, Young S, Koehrsen M, Engels R, et al (2009). Comparative genomic characterization of Francisella tularensis strains belonging to low and high virulence subspecies. PLoS Pathog, 5(5). Abstract. Author URL. Full text. Richards MI, Michell SL, Oyston PC (2008). An intracellularly inducible gene involved in virulence and polyphosphate production in Francisella. J Med Microbiol, 57(Pt 10), 1183-1192.