Jourdain, Isabelle - University of Exeter - Disciplines of Biosciences

个人简介

2000-2004: PhD, Molecular and Cellular Biology, René Descartes University, Paris V, France 1999-2000: MsC, Biology of Ageing, René Descartes University, Paris V, France 1995-1999: BsC, Biochemistry, Paul Sabatier University, Toulouse III, France Career 2014 - : Cell Biology lecturer, University of Exeter 2012 - 2013: Researcher, The Biotechnology Centre of Oslo, Norway 2008 - 2013: Senior Postdoctoral Research Fellow, Cancer Research UK, London 2005 - 2008: Postdoctoral Research Fellow, Massey University, Palmerston North, New Zealand 1999 - 2004: PhD and Master Student, Institut du Fer à Moulin, INSERM, Paris, France

研究领域

Research in my laboratory is aimed at describing the fundamental mechanisms that govern cell polarity. Virtually all cell types from all kingdoms use the same set of factors to adopt a shape that is compatible with a specialised function, a need for migration, or a growth and division pattern. Some of these factors are involved in remodeling the plasma membrane, others control the organization of the cytoskeleton. We are investigating both aspects and their link, with an emphasis on the following themes: How are the sequential steps of exocytosis coordinated? How does the cell periphery cross talk with the actin cytoskeleton? Can cell surface compartments restrict the sites of plasma membrane remodeling? To answer these questions, we routinely employ the yeast Schizosaccharomyces pombe as a model organism. S. pombe divides by fission and its characteristic shape makes it an ideal organism in which to study the morphological consequences of membrane trafficking alterations. Fission yeast also enables the use of a range of rapid, easy and ethical techniques from live cell imaging to genetics and biochemistry. By understanding how polarity is orchestrated in a simple organism such as fission yeast we will be able to assess the situation in more complex higher eukaryotes, notably in pathological conditions.

近期论文

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Jourdain I (eds)(2014). Mécanismes de séquestration de la tubuline: Etudes biochimiques de l'interaction entre la tubuline et les protéines de la famille de la stathmine. France, Presses Academiques Francophones. Abstract. Full text. Martin-Urdiroz M, Deeks MJ, Horton CG, Dawe HR, Jourdain I (2016). The Exocyst Complex in Health and Disease. Frontiers in Cell and Developmental Biology, 4 Full text. Article has an altmetric score of 8 Jourdain I, Brzezinska EA, Toda T (2013). Fission yeast Nod1 is a component of cortical nodes involved in cell size control and division site placement. PLoS One, 8(1). Abstract. Author URL. Full text. Jourdain I, Dooley HC, Toda T (2012). Fission yeast sec3 bridges the exocyst complex to the actin cytoskeleton. Traffic, 13(11), 1481-1495. Abstract. Author URL. Full text. Article has an altmetric score of 1 Jourdain I, Spielewoy N, Thompson J, Dhut S, Yates JR, Toda T (2009). Identification of a conserved F-box protein 6 interactor essential for endocytosis and cytokinesis in fission yeast. Biochem J, 420(2), 169-177. Abstract. Author URL. Jourdain I, Gachet Y, Hyams JS (2009). The dynamin related protein Dnm1 fragments mitochondria in a microtubule-dependent manner during the fission yeast cell cycle. Cell Motil Cytoskeleton, 66(8), 509-523. Abstract. Author URL. Röthlisberger S, Jourdain I, Johnson C, Takegawa K, Hyams JS (2009). The dynamin-related protein Vps1 regulates vacuole fission, fusion and tubulation in the fission yeast, Schizosaccharomyces pombe. Fungal Genet Biol, 46(12), 927-935. Abstract. Author URL. Jourdain I, Sontam D, Johnson C, Dillies C, Hyams JS (2008). Dynamin-dependent biogenesis, cell cycle regulation and mitochondrial association of peroxisomes in fission yeast. Traffic, 9(3), 353-365. Abstract. Author URL. Eaton CJ, Jourdain I, Foster SJ, Hyams JS, Scott B (2008). Functional analysis of a fungal endophyte stress-activated MAP kinase. Curr Genet, 53(3), 163-174. Abstract. Author URL. Clément MJ, Jourdain I, Lachkar S, Savarin P, Gigant B, Knossow M, Toma F, Sobel A, Curmi PA (2005). N-terminal stathmin-like peptides bind tubulin and impede microtubule assembly. Biochemistry, 44(44), 14616-14625. Abstract. Author URL. Article has an altmetric score of 3 Jourdain I, Lachkar S, Charbaut E, Gigant B, Knossow M, Sobel A, Curmi PA (2004). A synergistic relationship between three regions of stathmin family proteins is required for the formation of a stable complex with tubulin. Biochem J, 378(Pt 3), 877-888. Abstract. Author URL. Ravelli RB, Gigant B, Curmi PA, Jourdain I, Lachkar S, Sobel A, Knossow M (2004). Insight into tubulin regulation from a complex with colchicine and a stathmin-like domain. Nature, 428(6979), 198-202.