李霄鹏 - 深圳大学 - 化学与环境工程学院

个人简介

2020 – 至今深圳大学化学与环境工程学院，特聘教授 2019 – 2020 美国南佛罗里达大学化学系，副教授（终身） 2016 – 2019 美国南佛罗里达大学化学系，助理教授 2012 – 2016 美国德克萨斯州立大学化学与生物化学系，助理教授 2009 – 2012 美国阿克伦大学，博士后，导师： Chrys Wesdemiotis 2004 – 2008 美国克利夫兰州立大学，化学博士，导师：Baochuan Guo 1999 – 2004 郑州大学，化学学士

研究领域

（1）我们发展了基于多臂配体的多重配位自组装策略，实现了二维和三维超分子结构的精准构筑。这些具有精确结构的超分子可以进一步组装成为规则有序的纳米结构，并且具有独特的性质。（2）复杂超分子组装的不可控性和表征手段的缺乏已严重制约了此领域在功能方向的探索。针对此挑战，我们团队发展了基于多维度质谱和扫描隧道显微镜（STM）的表征技术，突破了具有大分子量和弱相互作用的超分子结构表征瓶颈。同时我们将探索制备级质谱与STM的一体化装置研制，即pMS-STM，此装置可实现大分子结构的原位可视化表征。（3）基于多重配位自组装和独特的表征手段，我们致力于具有分子层次精准度的新材料开发，探索的范围包括主客体化学、分子识别、反应调控、仿生催化、模板合成以及生物医学

近期论文

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Zhikai Li, Zhijun Zhang, Lingzhi Ma, Haifei Wen, Miaomiao Kang, Danxia Li, Wenjing Zhang, Siqi Luo, Weiguo Wang, Mingming Zhang, Dong Wang, Haiyang Li, Xiaopeng Li, HengWang.* Combining multiple photosensitizer modules into one supramolecular system for synergetic enhanced photodynamic therapy. Angew. Chem. Int. Ed., 2024, 63, e202400049. Jiaqi Liang, Shuai Lu, Yang Yang, Yun-Jia Shen, Jin-Ku Bai, Xin Sun, Xu-Lang Chen, Jie Cui, Ai-Jiao Guan, Jun-Feng Xiang, Xiaopeng Li, Heng Wang,* Yu-Dong Yang,* Han-Yuan Gong.* Thermally-induced atropisomerism promotes metal-organic cage construction. Nat. Commun., 2023, 14, 8166. Zhanpeng Zhang, Shuai Lu,* Xiujun Yu, Lei Hua, Weiguo Wang, Menglin Xue, Jianfeng Cai, Heng Wang,* Xiaopeng Li. Construction of metallo-helicoids with high antimicrobial activity via intermolecular coordination. Chem. Commun., 2023, 59, 13022–13025. Pingru Su, Wenjing Zhang, Chenxing Guo, Hong Liu, Chuanhong Xiong, Runxu Tang, Chuanxin He, Zhi Chen, Xiujun Yu, Heng Wang,* Xiaopeng Li. Constructing ultrastable metallo-cages via in situ deprotonation/oxidation of dynamic supramolecular assemblies. J. Am. Chem. Soc., 2023, 145, 18607–18622. Yi Qin, Xue Li, Shuai Lu, Miaomiao Kang, Zhijun Zhang,* Yixiong Gui, Xiaopeng Li, Dong Wang,* Ben Zhong Tang. Modular construction of AIE-active supramolecular cages with tunable fluorescence for NIR-II blood vessel imaging. ACS Materials Lett., 2023, 5, 1982–1991. Zhi Chen, Yinghao Xie, Heng Wang, Xiujun Yu,* Xiaopeng Li. Effects of metal cations and counter anions on the structural stability of isoquinoline-based metallo-supramolecular cages. Chin. J. Chem., 2023, 41, 2793–2800. Tolulope M. Ajayi, Nozomi Shirato, Tomas Rojas, Sarah Wieghold, Xinyue Cheng, Kyaw Zin Latt, Daniel J. Trainer, Naveen K. Dandu, Yiming Li, Sineth Premarathna, Sanjoy Sarkar, Daniel Rosenmann, Yuzi Liu, Nathalie Kyritsakas, Shaoze Wang, Eric Masson, Volker Rose,* Xiaopeng Li, Anh T. Ngo, Saw-Wai Hla.* Characterization of just one atom using synchrotron X-rays. Nature, 2023, 618, 69–73. Kai Wu, Tanya K. Ronson, Leonard Goh, Weichao Xue, Andrew W. Heard, Pingru Su, Xiaopeng Li, Mladen Vinković, Jonathan R. Nitschke.* A diverse array of large capsules transform in response to stimuli. J. Am. Chem. Soc., 2023, 145, 11356–11363. Yulong Zhong, Thomas A. Sobiech, Brice Kauffmann, Bo Song, Xiaopeng Li, Yann Ferrand, Ivan Huc, Bing Gong.* High-affinity single and double helical pseudofoldaxanes with cationic guests. Chem. Sci., 2023, 14, 4759–4768. Chenxing Guo, Feng Su, Pingru Su, Xiujun Yu,* Xiaopeng Li.* Luminescent terpyridine-based metallo-supramolecular systems: from design to applications. Sci. China Chem., 2023, 66, 1940–1962. Hongdi He, Shunran Zhang, Zhi Chen, Heng Wang, Xiujun Yu,* Xiaopeng Li.* Molecular complexes, supramolecular architectures and metallo-polymers based on chiral terpene-fused 2,2’:6’,2’’-terpyridines. Chem. Lett., 2023, 52, 370–380. Kai Wu, Tanya K. Ronson, Pingru Su, Zhi Chen, Leonard Goh, Andrew W. Heard, Xiaopeng Li, Fabian Klautzsch, Christoph A. Schalley, Mladen Vinković, Jonathan R. Nitschke.* Systematic construction of progressively larger capsules from a fivefold linking pyrrole-based subcomponent. Nature Synth., 2023, 2, 789–797. Xin Han, Chenxing Guo, Chen Xu, Linlin Shi, Binghui Liu, Zhe Zhang, Qixia Bai, Bo Song, Fangfang Pan, Shuai Lu, Xinju Zhu, Heng Wang,* Xin-Qi Hao,* Mao-Ping Song,* Xiaopeng Li.* Water-soluble metallo-supramolecular nanoreactors for mediating visible-light-promoted cross-dehydrogenative coupling reactions. ACS Nano, 2023, 17, 3723–3736. Shuai Lu, Darien J. Morrow, Zhikai Li, Chenxing Guo, Xiujun Yu, Heng Wang,* Jonathan D. Schultz, James P. O'Connor, Na Jin, Fang Fang, Wu Wang, Ran Cui, Ou Chen, Chenliang Su, Michael R. Wasielewski, Xuedan Ma,* Xiaopeng Li.* Encapsulating semiconductor quantum dots in supramolecular cages enables ultrafast guest–host electron and vibrational energy transfer. J. Am. Chem. Soc., 2023, 145, 5191–5202. Pingru Su, Biaowen Wei, Chenxing Guo, Yaqi Hu, Runxu Tang, Shunran Zhang, Chuanxin He, Jing Lin, Xiujun Yu, Zhi Chen, Haiyang Li, Heng Wang,* Xiaopeng Li. Metallo-supramolecular hexagonal wreath with four switchable states based on a pH-responsive tridentate ligand. J. Am. Chem. Soc., 2023, 145, 3131–3145. Zhenwen Wang, Lei Mei, Chenxing Guo, Song Huang, Wei-Qun Shi, Xiaowei Li, Wen Feng, Xiaopeng Li,* Cheng Yang,* Lihua Yuan.* Supramolecular shish kebabs: Higher order dimeric structures from ring-in-rings complexes with conformational adaptivity. Angew. Chem. Int. Ed., 2023, 62, e202216690. Qiangqiang Shi, Hao Yin, Rundi Song, Jie Xu, Jiajia Tan, Xin Zhou, Jie Cen, Zhengyu Deng, Huimin Tong, Chenhui Cui, Yanfeng Zhang, Xiaopeng Li, Zhengbiao Zhang, Shiyong Liu.* Digital micelles of encoded polymeric amphiphiles for direct sequence reading and ex vivo label-free quantification. Nature Chem., 2023, 15, 257–270. Kehuan Li, Shunran Zhang, Yaqi Hu, Shimin Kang, Xiujun Yu, Heng Wang, Ming Wang,* Xiaopeng Li.* Shape-dependent complementary ditopic terpyridine pair with two levels of self-recognition for coordination-driven self-assembly. Macromol. Rapid Commun., 2023, 44, 2200303. Yan Liu, Shou-Heng Liao, Wen-Tao Dai, Qixia Bai, Shuai Lu, Heng Wang, Xiaopeng Li, Zhe Zhang, Pingshan Wang, Wei Lu, Qi Zhang.* Controlled construction of heteroleptic [Pd2(LA)2(LB)(LC)]4+ cages: A facile approach for site-selective endo-functionalization of supramolecular cavities. Angew. Chem. Int. Ed., 2023, 62, e202217215. Qiong Dai, Tong Shu,* Huayan Yang, Lei Su, Xiaopeng Li, Xueji Zhang.* One-pot synthesis of stable antioxidant metal-ornamented polyphenol supramolecular assemblies for material engineering. NPG Asia Mater., 2022, 14, 97. Hong-Kun Liu, Furong Lin, Shang-Bo Yu,* Yan Wu, Shuai Lu, Yue-Yang Liu, Qiao-Yan Qi, Jin Cao, Wei Zhou,* Xiaopeng Li, Hui Wang, Dan-Wei Zhang, Zhan-Ting Li,* Da Ma.* Highly water-soluble cucurbit[8]uril derivative as a broad-spectrum neuromuscular block reversal agent. J. Med. Chem., 2022, 65, 16893–16901. Zhikai Li, Min Chen, Zhi Chen, You-Liang Zhu, Chenxing Guo, Heng Wang, Yi Qin, Fang Fang, Dong Wang, Chenliang Su, Chuanxin He, Xiujun Yu,* Zhong-Yuan Lu,* Xiaopeng Li.* Non-equilibrium nanoassemblies constructed by confined coordination on a polymer chain. J. Am. Chem. Soc., 2022, 144, 22651–22661. Xiujun Yu, Zhi Chen, Xiaopeng Li.* Reticular chemistry in action: 3D porphyrinic COFs with scu topology. Chem, 2022, 8, 2899–2901. Le-Ping Zhang, Chuan-Zhi Liu, Ming Liu,c Shuai Lu, Shang-Bo Yu, Qiao-Yan Qi,Guan-Yu Yang, Xiaopeng Li, Bo Yang,* Zhan-Ting Li.* CB[10]-driven self-assembly of a homotrimer froma symmetric organic dye: tunable multicolorfluorescence and higher solid-state stability than that of a CB[8]-included homodimer. Org. Chem. Front., 2022, 9, 6281–6289. Sumra Idrees,Zhikai Li, Fang Fang,Huowang He, Irfan Majeed, Yihuan Zhang, Atsuhiro Osuka,Yan Cao*, Zhuo Zeng*, Xiaopeng Li,* Hua-Wei Jiang.* Porphyrin nanotubes based on a hydrogen-bonded organic framework. Nanoscale, 2022, 14, 14630. Feng Su, Shunran Zhang, Zhi Chen, Zeyuan Zhang, Zhikai Li, Shuai Lu, Mingming Zhang, Fang Fang, Shimin Kang, Chenxing Guo, Chenliang Su, Xiujun Yu, Heng Wang,* Xiaopeng Li.* Precise synthesis of concentric ring, helicoid, and ladder metallo-polymers with chevron-shaped monomers. J. Am. Chem. Soc., 2022, 144, 16559–16571. Qian Feng, Tianfeng Yan, Lingzhi Ma, Xiaopeng Li, Hongye Yuan, Mingming Zhang,* Yanmin Zhang,* Lihong Fan.* Morpholine-functionalized multicomponent metallacage as a vector for lysosome-targeted cell imaging. ACS Appl. Mater. Interfaces., 2022, 14, 38594–38603. Xiujun Yu, Yaqi Hu, Chenxing Guo, Zhi Chen, Heng Wang, Xiaopeng Li.* Discrete terpyridine-lanthanide molecular and supramolecular complexes. Supramol. Mater., 2022, 1, 100017. Haifei Liu, Zeyuan Zhang, Chaoqun Mu, Lingzhi Ma, Hongye Yuan, Sanliang Ling, Heng Wang, Xiaopeng Li, Mingming Zhang.* Hexaphenylbenzene-based deep blue-emissive metallacages as donors for light-harvesting systems. Angew. Chem. Int. Ed., 2022, 61, e202207289. Zeyuan Zhang, Lingzhi Ma, Fang Fang, Yali Hou, Chenjie Lu, Chaoqun Mu, Yafei Zhang, Haifei Liu, Ke Gao, Ming Wang, Zixi Zhang, Xiaopeng Li, Mingming Zhang.* Porphyrin-based multicomponent metallacage: host-guest complexation toward photooxidation-triggered reversible encapsulation and release. JACS Au, 2022, 2, 1479–1487. Yuling Xu, Chonglu Li, Xin Ma, Wei Tuo, Le Tu, Xiaopeng Li, Yan Sun,* Peter J. Stang,* Yao Sun.* Long wavelength-emissive Ru(II) metallacycle-based photosensitizer assisting in vivo bacterial diagnosis and antibacterial treatment. Proc. Natl. Acad. Sci. U.S.A., 2022, 119, e2209904119. Ehsan Raee, Bingqing Liu, Yuqing Yang, Trishool Namani, Yunpeng Cui, Nita Sahai, Xiaopeng Li,* Tianbo Liu.* Side group of hydrophobic amino acids controls chiral discrimination among chiral counterions and metal-organic cages. Nano Lett., 2022, 22, 4421–4428. Furong Lin, Shang-Bo Yu,* Yue-Yang Liu, Chuan-Zhi Liu, Shuai Lu, Jin Cao, Qiao-Yan Qi, Wei Zhou,* Xiaopeng Li, Yi Liu, Jia Tian, Zhan-Ting Li.* Porous polymers as universal reversal agents for heparin anticoagulants through an inclusion-sequestration mechanism. Adv. Mater., 2022, 2200549. Chen Xu, Quanjie Lin, Chuan Shan, Xin Han, Hao Wang, Heng Wang,* Wenjing Zhang, Zhi Chen, Chenxing Guo, Yinghao Xie, Xiujun Yu, Bo Song, Heng Song, Lukasz Wojtas, Xiaopeng Li.* Metallo-supramolecular octahedral cages with three types of chirality towards spontaneous resolution. Angew. Chem. Int. Ed., 2022, 61, e202203099. Yuling Xu, Chonglu Li, Shuai Lu, Zhizheng Wang, Shuang Liu, Xiujun Yu, Xiaopeng Li,* Yao Sun.* Construction of emissive ruthenium(II) metallacycle over 1000 nm wavelength for in vivo biomedical applications. Nat. Commun., 2022, 13, 2009. Xiujun Yu, Chenxing Guo, Shuai Lu, Zhi Chen, Heng Wang, Xiaopeng Li.* Terpyridine-based 3D discrete metallosupramolecular architectures. Macromol. Rapid Commun., 2022, 43, 2200004. Heng Wang, Chenxing Guo, Xiaopeng Li.* Multidimensional mass spectrometry assisted metallo-supramolecular chemistry. CCS Chem., 2022, 4, 785–808. Shujin Bao, Zeming Xu, Tianchen Yu, Yinglin Song, Heng Wang, Zheng Niu,* Xiaopeng Li, Brendan F. Abrahams, Pierre Braunstein, Jian-Ping Lang.* Flexible vertex engineers the controlled assembly of distorted supramolecular tetrahedral and octahedral cages. Research, 2022, 9819343. Xiaotong Zhao, Heng Wang, Boyang Li, Wenyao Zhang, Xiaopeng Li, Wei Zhao, Christoph Janiak, Andrew W. Heard, Xiaojuan Yang, Biao Wu.* A hydrogen-bonded ravel assembled by anion coordination. Angew. Chem. Int. Ed., 2022, 61, e202115042. Heng Wang, Yiming Li, Na Li, Alexander Filosa, Xiaopeng Li.* Increasing the size and complexity of discrete 2D metallosupramolecules. Nature Rev. Mater., 2021, 6, 145–167. Zhewen Guo, Guangfeng Li, Heng Wang, Jun Zhao, Yuhang Liu, Hongwei Tan, Xiaopeng Li, Peter J. Stang,* Xuzhou Yan.* Drum-like metallacages with size-dependent fluorescence: Exploring the photophysics of tetraphenylethylene under locked conformations. J. Am. Chem. Soc., 2021, 143, 9215–9221. Heng Wang, Kun Wang, Yaping Xu, Wu Wang, Shaohua Chen, Matthew Hart, Lukasz Wojtas, Li-Peng Zhou, Lin Gan, Xuzhou Yan, Yiming Li, Juhoon Lee, Xian-Sheng Ke, Xu-Qing Wang, Chang-Wei Zhang, Shasha Zhou, Tianyou Zhai, Hai-Bo Yang, Ming Wang, Jiaqing He, Qing-Fu Sun, Bingqian Xu, Yang Jiao, Peter J. Stang, Jonathan L. Sessler,* Xiaopeng Li.* Hierarchical self-assembly of nanowires on the surface by metallo-supramolecular truncated cuboctahedra. J. Am. Chem. Soc., 2021, 143, 5826–5835. Junjuan Shi, Yiming Li, Xin Jiang, Hao Yu, Jiaqi Li, Houyu Zhang, Daniel J. Trainer, Saw Wai Hla, Heng Wang, Ming Wang,* Xiaopeng Li.* Self-assembly of metallo-supramolecules with dissymmetrical ligands and characterization by scanning tunneling microscopy. J. Am. Chem. Soc., 2021, 143, 1224–1234. Heng Wang, Li-Peng Zhou, Yu Zheng, Kun Wang, Bo Song, Xuzhou Yan, Lukasz Wojtas, Xu-Qing Wang, Xin Jiang, Ming Wang, Qing-Fu Sun, Bingqian Xu, Hai-Bo Yang, Andrew C-H Sue, Yi-Tsu Chan, Jonathan L Sessler, Yang Jiao, Peter J Stang, Xiaopeng Li.* Double-layered supramolecular prisms self-assembled by geometrically non-equivalent tetratopic subunits. Angew. Chem. Int. Ed., 2021, 60,1298–1305. Guang‐Qiang Yin, Sneha Kandapal, Chung‐Hao Liu, Heng Wang, Jianxiang Huang, Shu‐Ting Jiang, Tan Ji, Yu Yan, Sandra Khalife, Ruhong Zhou, Libin Ye, Bingqian Xu, Hai‐Bo Yang, Mu‐Ping Nieh, Xiaopeng Li.* Metallo‐helicoid with double rims: Polymerization followed by folding via intramolecular coordination. Angew. Chem. Int. Ed., 2021, 60, 1281–1289. Chaoqun Mu, Zeyuan Zhang, Yali Hou, Haifei Liu, Lingzhi Ma, Xiaopeng Li, Sanliang Ling, Gang He, Mingming Zhang.* Tetraphenylethylene-based multicomponent emissive metallacages as solid-state fluorescent materials. Angew. Chem. Int. Ed., 2021, 60, 12293–12297. Zhao-Tao Shi, Yi-Xiong Hu, Zhubin Hu, Qi Zhang, Shao-Yu Chen, Meng Chen, Jing-Jing Yu, Guang-Qiang Yin, Haitao Sun, Lin Xu, Xiaopeng Li, Ben L. Feringa,* Hai-Bo Yang,* He Tian, Da-Hui Qu.* Visible-light-driven rotation of molecular motors in discrete supramolecular metallacycles. J. Am. Chem. Soc., 2021, 143, 442–452. Pei-Pei Jia, Lin Xu,* Yi-Xiong Hu, Wei-Jian Li, Xu-Qing Wang, Qing-Hui Ling, Xueliang Shi, Guang-Qiang Yin, Xiaopeng Li, Haitao Sun, Yanrong Jiang, Hai-Bo Yang.* Orthogonal self-assembly of a two-step fluorescence-resonance energy transfer system with improved photosensitization efficiency and photooxidation activity. J. Am. Chem. Soc., 2021, 143, 399–408. Yali Hou, Zeyuan Zhang, Lingzhi Ma, Ruping Shi, Sanliang Ling, Xiaopeng Li, Gang He, Mingming Zhang.* Perylene diimide-based multicomponent metallacages as photosensitizers for visible light-driven photocatalytic oxidation reaction. CCS Chem., 2021, 3, 3153–3160. Baoxuan Huang, Xi Liu, Guoliang Yang, Jia Tian, Zhiyong Liu, Yucheng Zhu, Xiaopeng Li, Guangqiang Yin, Wei Zheng, Lin Xu,* Weian Zhang.* A Near-infrared organoplatinum(II) metallacycle conjugated with heptamethine cyanine for trimodal cancer therapy. CCS Chem., 2021, 3, 2055–2066. Mengjia Liu, Ying He, Chuan Shan, Lukasz Wojtas, Ion Ghiviriga, Omar Fathalla, Yu Yan, Xiaopeng Li, Xiaodong Shi.* Anion mediated, tunable isoguanosine self-assemblies: Decoding the conformation influence and solvent effect. Chem. Sci., 2021, 12, 7569–7574. Xiaotong Zhao, Heng Wang, Boyang Li, Bo Zheng, Dong Yang, Wenhua Xu, Xiaopeng Li, Xiao-Juan Yang, Biao Wu.* Narcissistic self-sorting in anion-coordination-driven assemblies. Chem. Commun., 2021, 12, 7569–7574. Yan-Yan Xu, Hong-Kun Liu, Ze-Kun Wang, Bo Song, Dan-Wei Zhang,* Hui Wang, Zhiming Li,* Xiaopeng Li, Zhan-Ting Li.* Olive-shaped organic cages: Synthesis and remarkable promotion of hydrazone condensation through encapsulation in water. J. Org. Chem., 2021, 86, 3943–3951. Qixia Bai, Tun Wu, Zhe Zhang, Lianghuan Xu, Zhengbin Tang, Yuming Guan, Ting-Zheng Xie, Mingzhao Chen, Peiyang Su, Heng Wang, Pingshan Wang,* Xiaopeng Li.* Clover leaf-shaped supramolecules assembled using a predesigned metallo-organic ligand. Org. Chem. Front., 2021, 8, 3244–3249. Zhewen Guo, Jun Zhao, Yuhang Liu, Guangfeng Li,* Heng Wang, Yali Hou, Mingming Zhang, Xiaopeng Li, Xuzhou Yan.* Conformational effect on fluorescence emission of tetraphenylethylene-based metallacycles. Chin. Chem. Lett., 2021, 32, 1691–1695. Chonglu Li, Pei-Pei Jia, Yu-Ling Xu, Feng Ding, Wen-Chao Yang, Yao Sun, Xiao-Peng Li, Guang-Qiang Yin, Lin Xu,* Guang-Fu Yang.* Photoacoustic imaging-guided chemo-photothermal combinational therapy based on emissive Pt(II) metallacycle-loaded biomimic melanin dots. Sci., China: Chem., 2021, 64, 134–142. Shiva K. Rastogi,* Zhenze Zhao, Brenton Gildner, Ben A. Shoulders, Tara L. Velasquez, Madeleine O. Blumenthal, Lei Wang, Xiaopeng Li, Todd W. Hudnall, Tania Betancourt, Liqin Du, William J. Brittain. Synthesis, optical properties and in vitro cell viability of novel spiropyrans and their photostationary states. Tetrahedron, 2021, 80, 131854. Yi-Xiong Hu, Gui-Yuan Wu, Xu-Qing Wang, Guang-Qiang Yin, Chang-Wei Zhang, Xiaopeng Li, Lin Xu,* Hai-Bo Yang.* Acid-activated motion switching of DB24C8 between two discrete platinum(II) metallacycles. Molecules, 2021, 26, 716. Kimberly G. Brady, Bingqing Liu, Xiaopeng Li, Lyle Isaacs.* Self-assembled cages with mechanically interlocked cucurbiturils. Supramol. Chem., 2021, 33, 8–32.