Harmer, Nicholas - University of Exeter - Disciplines of Biosciences

个人简介

2000-2004 PhD Biochemistry, University of Cambridge 1999-2000 MSci Natural Sciences, University of Cambridge 1996-2000 2003 MA Natural Sciences, University of Cambridge Career 2012-present Senior Lecturer in Structural Biochemistry, School of Biosciences, University of Exeter, UK 2007-2012 Lecturer in Structural Biochemistry, School of Biosciences, University of Exeter, UK 2006-2007 Senior Scientist, AstraZeneca R&D Molndal, Sweden 2003-2006 Research Associate, Department of Biochemistry, University of Cambridge, UK

研究领域

My research centres on understanding the molecular basis for activities essential to the pathogenic process of micro-organisms. I employ a wide range of experimental tools to gain a fuller picture of the role of each protein in these processes, and the interactions of proteins with ligands from either the micro-organism or the host. I have a strong interest in using Synthetic Biology to improve our understanding of microbial pathogenesis and to drive the production of novel treatments.

近期论文

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N'Diaye A, Mijouin L, Hillion M, Diaz S, Konto-Ghiorghi Y, Percoco G, Chevalier S, Lefeuvre L, Harmer NJ, Lesouhaitier O, et al (2016). Effect of Substance P in Staphylococcus aureus and Staphylococcus epidermidis Virulence: Implication for Skin Homeostasis. FRONTIERS IN MICROBIOLOGY, 7 Author URL. Full text. Article has an altmetric score of 1 Harmer NJ, Chahwan R (2016). Isotype switching: Mouse IgG3 constant region drives increased affinity for polysaccharide antigens. Virulence, 7(6), 623-626. Author URL. Full text. Article has an altmetric score of 1 sayer C, Finnigan W, Isupov MN, Levisson M, Kengen SWM, van der Oost J, Harmer NJ, Littlechild JA (2016). Structural and biochemical characterisation of Archaeoglobus fulgidus esterase reveals a bound CoA molecule in the vicinity of the active site. Scientific Reports, 6, 25542-25542. Abstract. Full text. Article has an altmetric score of 1 Blaszczyk M, Harmer NJ, Chirgadze DY, Ascher DB, Blundell TL (2015). Achieving high signal-to-noise in cell regulatory systems: Spatial organization of multiprotein transmembrane assemblies of FGFR and MET receptors. Progress in Biophysics and Molecular Biology, 118(3), 103-111. Abstract. Rosay T, Bazire A, Diaz S, Clamens T, Blier AS, Mijouin L, Hoffmann B, Sergent JA, Bouffartigues E, Boireau W, et al (2015). Pseudomonas aeruginosa Expresses a Functional Human Natriuretic Peptide Receptor Ortholog: Involvement in Biofilm Formation. MBio, 6(4). Abstract. Author URL. Full text. Article has an altmetric score of 5 Vivoli M, Isupov MN, Nicholas R, Hill A, Scott AE, Kosma P, Prior JL, Harmer NJ (2015). Unraveling the B. pseudomallei Heptokinase WcbL: from Structure to Drug Discovery. Chemistry and Biology, 22(12), 1622-1632. Abstract. Full text. Article has an altmetric score of 30 Begley DW, Fox D, Jenner D, Juli C, Pierce PG, Abendroth J, Muruthi M, Safford K, Anderson V, Atkins K, et al (2014). A structural biology approach enables the development of antimicrobials targeting bacterial immunophilins. Antimicrobial Agents and Chemotherapy, 58(3), 1458-1467. Abstract. Vivoli M, Novak HR, Littlechild JA, Harmer NJ (2014). Determination of protein-ligand interactions using differential scanning fluorimetry. J Vis Exp(91). Abstract. Author URL. Article has an altmetric score of 1 Vivoli M, Ayres E, Beaumont E, Isupov MN, Harmer NJ (2014). Structural insights into WcbI, a novel polysaccharide-biosynthesis enzyme. IUCrJ, 1, 28-38. Full text. Article has an altmetric score of 1 Butt A, Higman VA, Williams C, Crump MP, Hemsley CM, Harmer N, Titball RW (2014). The HicA toxin from Burkholderia pseudomallei has a role in persister cell formation. Biochem J, 459(2), 333-344. Abstract. Author URL. Full text. Article has an altmetric score of 2 Butt A, Harmer N, Müller C, Titball RW (2013). Identification of type II toxin-antitoxin modules in Burkholderia pseudomallei. FEMS Microbiol Lett, 338(1), 86-94. Abstract. Butt A, Müller C, Harmer N, Titball RW (2013). Identification of type II toxin-antitoxin modules in Burkholderia pseudomallei. FEMS Microbiol Lett, 338(1), 86-94. Abstract. Author URL. Full text. Cuccui J, Milne TS, Harmer N, George AJ, Harding SV, Dean RE, Scott AE, Sarkar-Tyson M, Wren BW, Titball RW, et al (2012). Characterization of the Burkholderia pseudomallei K96243 capsular polysaccharide I coding region. Infection and Immunity, 80, 1209-1221. Abstract. Author URL. Schuster M, Treitschke S, Kilaru S, Molloy J, Harmer NJ, Steinberg G (2012). Myosin-5, kinesin-1 and myosin-17 cooperate in secretion of fungal chitin synthase. EMBO J, 31(1), 214-227. Abstract. Author URL. Article has an altmetric score of 5 Norville IH, Harmer NJ, Harding SV, Fischer G, Keith KE, Brown KA, Sarkar-Tyson M, Titball RW (2011). A Burkholderia pseudomallei macrophage infectivity potentiator-like protein has rapamycin-inhibitable peptidylprolyl isomerase activity and pleiotropic effects on virulence. Infect Immun, 79(11), 4299-4307. Abstract. Author URL. Full text. Article has an altmetric score of 1 Norville IH, Breitbach K, Eske-Pogodda K, Harmer NJ, Sarkar-Tyson M, Titball RW, Steinmetz I (2011). A novel FK-506-binding-like protein that lacks peptidyl-prolyl isomerase activity is involved in intracellular infection and in vivo virulence of Burkholderia pseudomallei. Microbiology, 157(Pt 9), 2629-2638. Abstract. Author URL. Thomas RM, Twine SM, Fulton KM, Tessier L, Kilmury SLN, Ding W, Harmer N, Michell SL, Oyston PCF, Titbal RW, et al (2011). Glycosylation of DsbA in Francisella tularensis subsp. Tularensis. Journal of Bacteriology, 193(19), 5498-5509. Abstract. Norville I, O'Shea K, Sarkar-Tyson M, Zheng S, Titball RW, Varani G, Harmer NJ (2011). The structure of a Burkholderia pseudomallei immunophilin-inhibitor complex reveals new approaches to antimicrobial development. Biochemical Journal, 437, 413-422. Abstract. Harmer NJ (2010). The Structure of Sedoheptulose-7-Phosphate Isomerase from Burkholderia pseudomallei Reveals a Zinc Binding Site at the Heart of the Active Site. JOURNAL OF MOLECULAR BIOLOGY, 400(3), 379-392. Author URL. Full text. Goodger SJ, Robinson CJ, Murphy KJ, Gasiunas N, Harmer NJ, Blundell TL, Pye DA, Gallagher JT (2008). Evidence that heparin saccharides promote FGF2 mitogeneisis through two distinct mechanisms. Journal of Biological Chemistry, 283, 13001-13008.