廖佳宇 - 浙江大学

个人简介

2019.6- 浙江大学药学院，研究员 2018.5-2019.5 苏州诺华制药科技有限公司，Senior Scientist 2017.8-2018.5 新加坡国立大学化学系，博士后 2016.5-2016.11 新加坡国立大学化学系，研究助理 2012.8-2016.9 新加坡国立大学，有机化学，博士 2008.9-2012.6 浙江大学，药学，学士

研究领域

1. 杂环化合物的合成方法学及生物活性研究 2. 药物设计、合成以及构效关系研究 3. 人工智能助力新药研发

近期论文

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Zhang-Hong Luo, Wen-Tao Wang, Tian-Yi Tang (UG), Sen Zhang, Fen Huang, Dan Hu, Ling-Fei Tao, Linghui Qian, and Jia-Yu Liao.* Torsional Strain-Independent Catalytic Enantioselective Synthesis of Biaryl Atropisomers. Angew. Chem. Int. Ed. 2022, DOI: 10.1002/anie.202211303. (UG: 本科生) Ling-Fei Tao, Linghui Qian,* and Jia-Yu Liao.* Catalytic Asymmetric [3+3] Cycloaddition of Activated Isocyanides with Azomethine Imines, Synlett 2022, DOI: 10.1055/a-1904-0582. (invited highlight) Sen Zhang, Zhang-Hong Luo, Wen-Tao Wang, Linghui Qian,* and Jia-Yu Liao.* Simultaneous Construction of C-N Axial and Central Chirality via Silver-Catalyzed Desymmetrizative [3+2] Cycloaddition of Prochiral N‑Aryl Maleimides with Activated Isocyanides, Org. Lett. 2022, 24, 4645-4649. Wen-Tao Wang,# Sen Zhang,# Ling-Fei Tao, Zi-Qi Pan (UG), Linghui Qian,* and Jia-Yu Liao.* Cooperative catalysis-enabled C-N bond cleavage of biaryl lactams with activated isocyanides, Chem. Commun. 2022, 58, 6292-6295. (# These authors contributed equally to this work; UG: 本科生) This article is part of the themed collection: Chemical Communications HOT Articles 2022. Jia-Yu Liao.* “Introducing…” profile, Angew. Chem. Int. Ed. 2022, 61, e202204494. Ling-Fei Tao,# Sen Zhang,# Fen Huang, Wen-Tao Wang, Zhang-Hong Luo, Linghui Qian,* and Jia-Yu Liao.* Diastereo- and Enantioselective Silver-Catalyzed [3+3] Cycloaddition and Kinetic Resolution of Azomethine Imines with Activated Isocyanides, Angew. Chem. Int. Ed. 2022, 61, e202202679. (# These authors contributed equally to this work.) Jinning Shao,# Yue Liu,# Jiaqi Yan,# Ze-Yi Yan, Yangyang Wu, Zhongying Ru, Jia-Yu Liao,* Xiaoye Miao,* and Linghui Qian.* Prediction of Maximum Absorption Wavelength Using Deep Neural Networks, J. Chem. Inf. Model. 2022, 62, 1368-1375. (# These authors contributed equally to this work.) Yulong Kong, Kui Zeng, Ying Zhang, Jinning Shao, Jiaqi Yan, Jia-Yu Liao, Wenchao Wang, Xiaoyang Dai, Qinjie Weng, Shao Q. Yao, Su Zeng,* and Linghui Qian.* In vivo targeted delivery of antibodies into cancer cells with pH-responsive cell-penetrating poly(disulfide)s, Chem. Commun. 2022, 58, 1314-1317. Linghui Qian,# Ling-Fei Tao,# Wen-Tao Wang, Ehtesham Jameel, Zhang-Hong Luo, Tao Zhang, Yu Zhao, and Jia-Yu Liao.* Catalytic Atroposelective Dynamic Kinetic Resolution of Biaryl Lactones with Activated Isocyanides. Org. Lett. 2021, 23, 5086-5091. (# These authors contributed equally to this work.) Yuchen Zhu (UG), Jia-Yu Liao,* and Linghui Qian.* Isocyanides: Promising Species in Bioorthogonal Labeling of Biomolecules. Front. Chem. 2021, 9, 670751. (UG: 本科生) Caizhi Wu, Jiayu Liao, and Shaozhong Ge.* Cobalt-Catalyzed Enantioselective Hydroboration/Cyclization of 1,7-Enynes: Asymmetric Synthesis of Chiral Quinolinones Containing Quaternary Stereogenic Centers. Angew. Chem. Int. Ed. 2019, 58, 8882-8886. Selected as Hot Paper. Germaine Pui Yann Kok,# Pan-Lin Shao,#* Jia-Yu Liao, Siti Nur Fairuz Bte Sheikh Ismail, Weijun Yao, Yixin Lu,* and Yu Zhao.* Divergent, Enantioselective Synthesis of Pyrroles, 3H-Pyrroles and Bicyclic Imidazolines by Ag- or P-Catalyzed [3+2] Cycloaddition of Allenoates with Activated Isocyanides. Chem. Eur. J. 2018, 24, 10513-10520. (# These authors contributed equally to this work.) Selected as Hot Paper. Jia-Yu Liao, Qijian Ni, and Yu Zhao.* Catalyst-Enabled Scaffold Diversity: Highly Chemo- and Stereoselective Synthesis of Tricyclic Ketals and Triarylmethanes. Org. Lett. 2017, 19, 4074-4077. Highlighted in Synfacts 2017, 13, 1053. Jia-Yu Liao, Wei Jie Yap, Ji'En Wu, Ming Wah Wong,* and Yu Zhao.* Three-Component Reactions of Isocyanoacetates, Amines and 3-Formylchromones Initiated by an Unexpected aza-Michael Addition. Chem. Commun. 2017, 53, 9067-9070. Jia-Yu Liao,# Pan-Lin Shao,# and Yu Zhao.* Catalytic Divergent Synthesis of 3H or 1H Pyrroles by [3+2] Cyclization of Allenoates with Activated Isocyanides. J. Am. Chem. Soc. 2015, 137, 628-631. (# These authors contributed equally to this work.) Pan-Lin Shao, Jia-Yu Liao, Yee Ann Ho, and Yu Zhao.* Highly Diastereo- and Enantioselective Silver-Catalyzed Double [3+2] Cyclization of α-Imino Esters with Isocyanoacetate. Angew. Chem. Int. Ed. 2014, 53, 5435-5439. Highlighted in Synfacts 2014, 10, 0846. Linghui Qian, Jiayu Liao, Yani Li, Xiaofan Mo, Li Ma, and Tongwei Yao.* Comparison of Three Methods on Assay for Vitamin A: UV, NP-HPLC and RP-HPLC. Experimental Technology and Management 2012, 5, 43-48.