Gudelj, Ivana - University of Exeter - Disciplines of Biosciences

个人简介

1998 – 2002 PhD in Applied Mathematics, University of Bath 1994 – 1998 BSc in Mathematical Sciences, University of Bath Career 2015 – present Professor of Evolutionary Systems Biology, Biosciences, University of Exeter 2012 – 2015 Associate Professor of Evolutionary Systems Biology, Biosciences, University of Exeter 2011 – present NERC Advanced Fellow/ Associate Professor in Systems Biology, Biosciences, University of Exeter 2008 – 2010 NERC Advanced Fellow/ Lecturer in Applied Mathematics, Department of Mathematics, Imperial College London 2007 - 2008 NERC Advanced Fellow, Department of Mathematics, University of Bath 2006 – 2007 NERC EMS Fellow, Department of Mathematics, University of Bath 2004 – 2006 NERC EMS Fellow, NERC Centre for Population Biology, Imperial College London 2001 – 2004 Postdoctoral Research Associate, Rothamsted Research

研究领域

Microbes are ubiquitous in nature and occupy virtually every environmental niche on earth. Contributing to this evolutionary success are diverse metabolic strategies as well as the ability to adapt to changing environments. Microbes can be extremely beneficial. They play an important role in cycling vital elements such as carbon and nitrogen and can be used for biodegradation of soil and water pollutants. However microbes can also have devastating impact on human heath. They are the biggest killer of hospital patients in intensive care units. Moreover microbes can also cause severe plant disease and are responsible for huge harvest losses each year. Experimental evolution has provided an ideal setting for studying microbes in action – from the adaptation to novel environments, diversification, through to the evolution of drug resistance. Such experiments are conducted in controlled environments using culturable strains that are easily manipulated, raising the following important questions: How do we know whether a given experimental outcome is particular to the laboratory system? What can we learn from laboratory experiments about microorganisms in the wild? My group utilizes theoretical and experimental approaches to answer fundamental questions in evolutionary biology. By developing novel modeling approaches that bring together cellular, molecular, genetic levels systems biology into a population level framework we strive to bridge the gap between laboratory experiments and the real world. We also closely collaborate with microbiologists and experimental evolutionary biologists from all over the world.

近期论文

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Meyer JR, Gudelj I, Beardmore R (2015). Biophysical mechanisms that maintain biodiversity through trade-offs. Nat Commun, 6 Abstract. Author URL. Full text. Article has an altmetric score of 17 Fuentes-Hernandez A, Plucain J, Gori F, Pena-Miller R, Reding C, Jansen G, Schulenburg H, Gudelj I, Beardmore R (2015). Using a sequential regimen to eliminate bacteria at sublethal antibiotic dosages. PLoS Biol, 13(4). Abstract. Author URL. Full text. Article has an altmetric score of 128 Sieber M, Robb M, Forde SE, Gudelj I (2014). Dispersal network structure and infection mechanism shape diversity in a coevolutionary bacteria-phage system. ISME Journal, 8(3), 504-514. Abstract. Article has an altmetric score of 4 Sieber M, Gudelj I (2014). Do-or-die life cycles and diverse post-infection resistance mechanisms limit the evolution of parasite host ranges. Ecology Letters, 17(4), 491-498. Abstract. Peña-Miller R, Fuentes-Hernandez A, Reding C, Gudelj I, Beardmore R (2014). Testing the optimality properties of a dual antibiotic treatment in a two-locus, two-allele model. J R Soc Interface, 11(96). Abstract. Author URL. Article has an altmetric score of 3 Maharjan R, Nilsson S, Sung J, Haynes K, Beardmore RE, Hurst LD, Ferenci T, Gudelj I (2013). The form of a trade-off determines the response to competition. Ecology Letters, 16(10), 1267-1276. Article has an altmetric score of 93 Maharjan R, Nilsson S, Sung J, Haynes K, Beardmore RE, Hurst LD, Ferenci T, Gudelj I (2013). The form of a trade-off determines the response to competition. Ecol Lett, 16(10), 1267-1276. Abstract. Author URL. Article has an altmetric score of 93 Levert M, Zamfir O, Clermont O, Bouvet O, Lespinats S, Hipeaux MC, Branger C, Picard B, Saint-Ruf C, Norel F, et al (2011). Correction: Molecular and Evolutionary Bases of Within-Patient Genotypic and Phenotypic Diversity in Escherichia coli Extraintestinal Infections. PLoS Pathog, 7(6). Abstract. Beardmore RE, Gudelj I, Lipson DA, Hurst LD (2011). Metabolic trade-offs and the maintenance of the fittest and the flattest. Nature, 472(7343), 342-346. Abstract. Author URL. Full text. Article has an altmetric score of 8 MaClean RC, Fuentes-Hernandez A, Greig D, Hurst LD, Gudelj I (2010). A mixture of "cheats" and "co-operators" can enable maximal group benefit. PLoS Biol, 8(9). Abstract. Author URL. Full text. Article has an altmetric score of 14 Gudelj I, Weitz JS, Ferenci T, Claire Horner-Devine M, Marx CJ, Meyer JR, Forde SE (2010). An integrative approach to understanding microbial diversity: from intracellular mechanisms to community structure. Ecol Lett, 13(9), 1073-1084. Abstract. Author URL. Estrela S, Gudelj I (2010). Evolution of cooperative cross-feeding could be less challenging than originally thought. PLoS One, 5(11). Abstract. Author URL. Full text. Levert M, Zamfir O, Clermont O, Bouvet O, Lespinats S, Hipeaux MC, Branger C, Picard B, Saint-Ruf C, Norel F, et al (2010). Molecular and evolutionary bases of within-patient genotypic and phenotypic diversity in Escherichia coli extraintestinal infections. PLoS Pathog, 6(9). Abstract. Author URL. Full text. Article has an altmetric score of 1 Forde SE, Beardmore RE, Gudelj I, Arkin SS, Thompson JN, Hurst LD (2008). Understanding the limits to generalizability of experimental evolutionary models. Nature, 455(7210), 220-223. Abstract. Author URL. Full text. Gudelj I, Beardmore RE, Arkin SS, MacLean RC (2007). Constraints on microbial metabolism drive evolutionary diversification in homogeneous environments. J Evol Biol, 20(5), 1882-1889. Abstract. Author URL. Article has an altmetric score of 1 Gudelj I, Coman CD, Beardmore RE (2006). Classifying the role of trade-offs in the evolutionary diversity of pathogens. Proceedings of the Royal Society A: Mathematical, Physical and Engineering Sciences, 462(2065), 97-116. Abstract. MacLean RC, Gudelj I (2006). Resource competition and social conflict in experimental populations of yeast. Nature, 441(7092), 498-501. Abstract. Author URL. Article has an altmetric score of 4 Gudelj I, Fitt BD, van den Bosch F (2004). Evolution of sibling fungal plant pathogens in relation to host specialization. Phytopathology, 94(7), 789-795. Abstract. Author URL. Gudelj I, White KA (2004). Spatial heterogeneity, social structure and disease dynamics of animal populations. Theor Popul Biol, 66(2), 139-149. Abstract. Author URL. Gudelj I, White KA, Britton NF (2004). The effects of spatial movement and group interactions on disease dynamics of social animals. Bull Math Biol, 66(1), 91-108.