Zhang, Chi - Purdue University - Department of Chemistry

个人简介

B.S., Tianjin University, Opto-electronics, 2006 M.S., Tianjin University, Opto-electronics, 2008 Ph.D., University of Michigan, Chemistry, 2014

研究领域

(1) Optical spectroscopy and imaging We develop novel optical spectroscopy and microscopy technologies to map chemical contrast and processes in biological and material samples. Our spectroscopy and imaging modalities are based on nonlinear optical processes, including coherent Raman scattering, harmonic generation, multiphoton excitation fluorescence, and transient absorption. We are interested in improving the chemical selectivity, throughout, and sensitivity of chemical imaging technologies. (2) Real-time precision opto-control (RPOC) We develop new precision opto-control platforms and use lasers to control chemical processes in living cells. Our method can selectively control chemical processes in living samples without affecting other parts of the sample. RPOC has high chemical specificity, submicron precision, and nanosecond response time. (3) Understanding and controlling cell metabolism We apply imaging and spectroscopy technologies developed in our lab to understand the metabolism of cancer and bacteria cells, especially in stress conditions. We also use precision opto-control technologies to manipulate and control cell metabolism.

近期论文

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M.G.Clark, G. Gonzalez, J. Aldana-Mendoza, M.S. Carlsen, G. Eakins, and C. Zhang*. "Real-time precision opto-control of chemical processes in live cells". bioRxiv 2022.01.23.477373; doi: https://doi.org/10.1101/2022.01.23.477373 C. Zhang* and J. A. Aldana-Mendoza. "Coherent Raman scattering microscopy for chemical imaging of biological systems", J. Phys. Photon. 3, 032002 (2021) Link P. Mukherjee, E. Aksamitiene, A. Alex, J. Shi, K. Bera, C. Zhang, D. Spillman, M. Marjanovic, M. Fazio, P.P. Seth, K. Frazier, S.R. Hood, and S.A. Boppart*. "Differential Uptake of Antisense Oligonucleotides in Mouse Hepatocytes and Macrophages Revealed by Simultaneous Two-Photon Excited Fluorescence and Coherent Raman Imaging", Nucleic Acid Ther., DOI: 10.1089/nat.2021.0059. C. Zhang and S. A. Boppart*. "Tracking the formation and degradation of fatty-acid-accumulated mitochondria using label-free chemical imaging", Sci. Rep. 11, 6671 (2021) Link C. Zong, C. Zhang, P. Lin, J. Yin, Y. Bai, H. Lin, B. Ren*, and J. Cheng*. "Real-time imaging of surface chemical reactions by electrochemical photothermal reflectance microscopy", Chem. Sci., 12, 1930-1936 (2021) Link 43. C. Zhang and S. A. Boppart*. "Dynamic signatures of lipid droplets as new markers to quantify cellular metabolic changes", Anal. Chem., 92, 15943–15952 (2020). Link K. Huang#, J. Li#, C. Zhang#, Y. Tan, J.X. Cheng*. “Multiplex stimulated Raman scattering imaging cytometry reveals cancer metabolic signatures in a spatially and spectrally resolved manner”, iScience, 23, 100953, (2020). C. Zong, R. Premasiri, H. Lin, Y. Huang, C. Zhang, C. Yang, B. Ren, L.D. Ziegler, J.X. Cheng*. “Plasmon-enhanced stimulated Raman scattering microscopy with Single-molecule detection sensitivity”, Nat. Commun., 10, 5318, (2019). J.H. Lee#, J.J. Rico-Jimenez#, C. Zhang, A. Alex, E.J. Chaney, R. Barkalifa, D.R. Spillman, M. Marjanovic, Z. Arp, S.R. Hood, and S.A. Boppart*. “Simultaneous label-free autofluorescence and multi-harmonic imaging reveals in vivo structural and metabolic changes in murine skin”, Biomed. Opt. Express, 10, 5421-5444 (2019). X. Chen*, S.P. Zhu, H.Y. Wang, C.P. Bao, D.F. Yang, C. Zhang, P. Lin, J.X. Cheng, Y.H. Zhan, J.M. Liang, and J. Tian*. “Accelerated stimulated Raman projection tomography by sparse reconstruction from sparse-view data”, IEEE Trans. Biomed. Eng., 10.1109/TBME.2019.2935301 (2019). Y. Sun, H. Tu, S. You, C. Zhang, Y. Liu, and S.A. Boppart*. “Detection of weak near-infrared optical imaging signals under ambient light by optical parametric amplification”, Opt. Lett., 17, 4391-4394, (2019). C. Zhang, J.X. Cheng*, “Coherent Raman scattering imaging: the future is bright”, Appl. Phys. Lett. Photonics, 3, 090901 (2018). Y. Urasaki#, C. Zhang#, J.X. Cheng, T.T. Le, “Quantitative assessment of liver steatosis and affected pathways with molecular imaging and proteomic profiling”, Sci. Rep., 8, 3606, (2018). C. Zhang#, J. Li#, L. Lan, and J.X. Cheng* “Quantification of lipid metabolism through the dynamics of lipid droplets in living cells by stimulated Raman scattering imaging”, Anal. Chem., 89, 4502-4507, (2017). X. Chen#, C. Zhang#, P. Lin, K. Huang, J. Liang, J. Tian, and J.X. Cheng* “Volumetric chemical imaging by stimulated Raman projection microscopy and tomography”, Nat. Commun., 8, 15117, (2017). C. Zhang* “Sum frequency generation vibrational spectroscopy for characterization of buried polymer interfaces” Focal Point Review, Appl. Spectrosc., 71, 1717-1749 (2017). C. Zhang#, K. Huang#, B. Rajwa, J. Li, S. Yang, H. Lin, C. Liao, G. Eakins, S. Kuang, V. Patsekin, J.P. Robinson, J.X. Cheng* “Label-free single-particle analysis by stimulated Raman scattering flow cytometry”, Optica, 4, 103-109 (2017). X. Lu*, C. Zhang, Z. Chen* “Studying polymer surfaces and interfaces with sum frequency generation vibrational spectroscopy”, Anal. Chem., 89, 466-489 (2016). D. Zhang, C. Li, C. Zhang, M. N. Slipchenko, G. Eakins, J.X. Cheng*, “Depth-resolved mid-infrared photothermal imaging of living cells and organisms with sub-micro spatial resolution”, Sci. Adv., 2, e1600521. (2016). J. Jasensky, A. Boughton, A. Khamaladze, J. Ding, C. Zhang, J. Swain, G. Smith, Z. Chen*, G. Smith*, “Live-cell quantification and comparison of mammalian oocyte cytosolic lipid content between species during development, and in relation to body composition using nonlinear vibrational microscopy”, Analyst, 141, 4694-4706 (2016).