Lin, Hang - University of Pittsburgh

个人简介

University of Pittsburgh, 2015-17, Research Instructor University of Pittsburgh, 2010-15, Postdoc associate National Institutes of Health, 2008-10, Postdoc fellow Institute of genetics and developmental biology, CAS, 2002-08, PhD Nanjing University, 1998-02, BS

研究领域

The goal of Lin Lab is to apply the latest biological knowledge and state-of-art technology in orthopaedic research and translate the research findings into effective treatments for joint diseases. Focusing on translational research, there are three integrated projects in Lin Lab: investigating the association between aging and OA; establishing an in vitro microphysiological OA model for OA pathogenesis study and drug development; testing the stem cell-based therapy for the repair of cartilage injury.

近期论文

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Xie M, Zhang Y, Xiong Z, Hines S, Shang J, Clark KL, Tan S, Alexander PG, Lin H. Generation of hyaline-like cartilage tissue from human mesenchymal stromal cells within the self-generated extracellular matrix. Acta Biomater. 2022 Sep 1;149:150-166. doi: 10.1016/j.actbio.2022.06.040. Epub 2022 Jun 30. PubMed PMID: 35779770. Li ZA, Sant S, Cho SK, Goodman SB, Bunnell BA, Tuan RS, Gold MS, Lin H. Synovial joint-on-a-chip for modeling arthritis: progress, pitfalls, and potential. Trends Biotechnol. 2022 Aug 19;. doi: 10.1016/j.tibtech.2022.07.011. [Epub ahead of print] Review. PubMed PMID: 35995600; NIHMSID:NIHMS1827014. He C, Clark KL, Tan J, Zhou H, Tuan RS, Lin H, Wu S, Alexander PG. Modeling early changes associated with cartilage trauma using human-cell-laden hydrogel cartilage models. Stem Cell Res Ther. 2022 Aug 4;13(1):400. doi: 10.1186/s13287-022-03022-8. PubMed PMID: 35927702; PubMed Central PMCID: PMC9351070. O'Donnell BT, Monjure TA, Al-Ghadban S, Ives CJ, L'Ecuyer MP, Rhee C, Romero-Lopez M, Li Z, Goodman SB, Lin H, Tuan RS, Bunnell BA. Aberrant Expression of COX-2 and FOXG1 in Infrapatellar Fat Pad-Derived ASCs from Pre-Diabetic Donors. Cells. 2022 Aug 1;11(15). doi: 10.3390/cells11152367. PubMed PMID: 35954211; PubMed Central PMCID: PMC9367583. Li Z, Lin Z, Liu S, Yagi H, Zhang X, Yocum L, Romero-Lopez M, Rhee C, Makarcyzk MJ, Yu I, Li EN, Fritch MR, Gao Q, Goh KB, O'Donnell B, Hao T, Alexander PG, Mahadik B, Fisher JP, Goodman SB, Bunnell BA, Tuan RS, Lin H. Human Mesenchymal Stem Cell-Derived Miniature Joint System for Disease Modeling and Drug Testing. Adv Sci (Weinh). 2022 Jul;9(21):e2105909. doi: 10.1002/advs.202105909. Epub 2022 Apr 18. PubMed PMID: 35436042; PubMed Central PMCID: PMC9313499. Hartung JE, Moy JK, Loeza-Alcocer E, Nagarajan V, Jostock R, Christoph T, Schroeder W, Gold MS. Voltage-gated calcium currents in human dorsal root ganglion neurons. Pain. 2022 Jun 1;163(6):e774-e785. doi: 10.1097/j.pain.0000000000002465. Epub 2021 Aug 27. PubMed PMID: 34510139; PubMed Central PMCID: PMC8882208. Lin Z, Zhang X, Fritch MR, Li Z, Kuang B, Alexander PG, Hao T, Cao G, Tan S, Bruce KK, Lin H. Engineering pre-vascularized bone-like tissue from human mesenchymal stem cells through simulating endochondral ossification. Biomaterials. 2022 Apr;283:121451. doi: 10.1016/j.biomaterials.2022.121451. Epub 2022 Mar 1. PubMed PMID: 35259584. Wang N, He Y, Liu S, Makarcyzk MJ, Lei G, Chang A, Alexander PG, Hao T, Padget AM, de Pedro N, Menelaos T, Lin H. Engineering osteoarthritic cartilage model through differentiating senescent human mesenchymal stem cells for testing disease-modifying drugs. Sci China Life Sci. 2022 Feb;65(2):309-327. doi: 10.1007/s11427-021-1933-7. Epub 2021 Jun 4. PubMed PMID: 34109475. Wang X, Guan Y, Xiang S, Clark KL, Alexander PG, Simonian LE, Deng Y, Lin H. Role of Canonical Wnt/β-Catenin Pathway in Regulating Chondrocytic Hypertrophy in Mesenchymal Stem Cell-Based Cartilage Tissue Engineering. Front Cell Dev Biol. 2022;10:812081. doi: 10.3389/fcell.2022.812081. eCollection 2022. Review. PubMed PMID: 35141220; PubMed Central PMCID: PMC8820467. Gao Q, Li Z, Rhee C, Xiang S, Maruyama M, Huang EE, Yao Z, Bunnell BA, Tuan RS, Lin H, Gold MS, Goodman SB. Macrophages Modulate the Function of MSC- and iPSC-Derived Fibroblasts in the Presence of Polyethylene Particles. Int J Mol Sci. 2021 Nov 27;22(23). doi: 10.3390/ijms222312837. PubMed PMID: 34884641; PubMed Central PMCID: PMC8657553. Li Z, Xiang S, Lin Z, Li EN, Yagi H, Cao G, Yocum L, Li, Hao T, Bruce KK, Fritch MR, Hu H, Wang B, Alexander PG, Khor KA, Tuan RS, Lin H. Graphene oxide-functionalized nanocomposites promote osteogenesis of human mesenchymal stem cells via enhancement of BMP-SMAD1/5 signaling pathway. Biomaterials. 2021 Oct;277:121082. doi: 10.1016/j.biomaterials.2021.121082. Epub 2021 Aug 24. PubMed PMID: 34464823; PubMed Central PMCID: PMC8478843. Xie M, Fritch M, He Y, Fu H, Hong Y, Lin H. Dynamic loading enhances chondrogenesis of human chondrocytes within a biodegradable resilient hydrogel. Biomater Sci. 2021 Jul 13;9(14):5011-5024. doi: 10.1039/d1bm00413a. PubMed PMID: 34109952. He Y, Yocum L, Alexander PG, Jurczak MJ, Lin H. Urolithin A Protects Chondrocytes From Mechanical Overloading-Induced Injuries. Front Pharmacol. 2021;12:703847. doi: 10.3389/fphar.2021.703847. eCollection 2021. PubMed PMID: 34220525; PubMed Central PMCID: PMC8245698. Xiang S, Li Z, Fritch MR, Li, Velankar S, Liu Y, Sohn J, Baker N, Lin H, Tuan RS. Caveolin-1 mediates soft scaffold-enhanced adipogenesis of human mesenchymal stem cells. Stem Cell Res Ther. 2021 Jun 14;12(1):347. doi: 10.1186/s13287-021-02356-z. PubMed PMID: 34127047; PubMed Central PMCID: PMC8201886. Gao Q, Rhee C, Maruyama M, Li Z, Shen H, Zhang N, Utsunomiya T, Huang EE, Yao Z, Bunnell BA, Lin H, Tuan RS, Goodman SB. The Effects of Macrophage Phenotype on Osteogenic Differentiation of MSCs in the Presence of Polyethylene Particles. Biomedicines. 2021 May 1;9(5). doi: 10.3390/biomedicines9050499. PubMed PMID: 34062822; PubMed Central PMCID: PMC8147332. Huang Y, He Y, Makarcyzk MJ, Lin H. Senolytic Peptide FOXO4-DRI Selectively Removes Senescent Cells From in vitro Expanded Human Chondrocytes. Front Bioeng Biotechnol. 2021;9:677576. doi: 10.3389/fbioe.2021.677576. eCollection 2021. PubMed PMID: 33996787; PubMed Central PMCID: PMC8116695. Shen H, He Y, Wang N, Fritch MR, Li X, Lin H, Tuan RS. Enhancing the potential of aged human articular chondrocytes for high-quality cartilage regeneration. FASEB J. 2021 Mar;35(3):e21410. doi: 10.1096/fj.202002386R. PubMed PMID: 33617078; PubMed Central PMCID: PMC8041516. Makarczyk MJ, Gao Q, He Y, Li Z, Gold MS, Hochberg MC, Bunnell BA, Tuan RS, Goodman SB, Lin H. Current Models for Development of Disease-Modifying Osteoarthritis Drugs. Tissue Eng Part C Methods. 2021 Feb;27(2):124-138. doi: 10.1089/ten.TEC.2020.0309. Epub 2021 Feb 4. Review. PubMed PMID: 33403944; PubMed Central PMCID: PMC8098772. Li Z, Xiang S, Li EN, Fritch MR, Alexander PG, Lin H, Tuan RS. Tissue Engineering for Musculoskeletal Regeneration and Disease Modeling. Handb Exp Pharmacol. 2021;265:235-268. doi: 10.1007/164_2020_377. PubMed PMID: 33471201; PubMed Central PMCID: PMC8049527.